Cardioprotective actions of human superoxide dismutase in two reperfusion models of myocardial ischaemia in the rat.

abstract：BACKGROUND AND PURPOSE:Post-operative ileus (POI) is induced by intestinal inflammation. Here, we aimed to clarify the effects of 5-HT3 receptor antagonists against POI. EXPERIMENTAL APPROACH:We administered three 5-HT3 receptor antagonists, ondansetron, tropisetron and palonosetron, to a mouse model of POI induced by...

journal_title：British journal of pharmacology

authors： Maehara T,Matsumoto K,Horiguchi K,Kondo M,Iino S,Horie S,Murata T,Tsubone H,Shimada S,Ozaki H,Hori M

更新日期：2015-02-01 00:00:00

abstract：:1. This study investigated whether (a) cannabinoid CB(1) receptor knockout (CB(1)(-/-)) mice displayed altered gastrointestinal transit and (b) cannabinoid CB(1) and opioid receptors functionally interact in the regulation of gastrointestinal transit. 2. Gastrointestinal transit was assessed by the Whole Gastrointesti...

journal_title：British journal of pharmacology

authors： Carai MA,Colombo G,Gessa GL,Yalamanchili R,Basavarajappa BS,Hungund BL

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:An alteration in the communication between the innate and adaptive immune cells is a hallmark of ulcerative colitis (UC). Semaphorin-3E (SEMA3E), a secreted guidance protein, regulates various immune responses. EXPERIMENTAL APPROACH:We investigated the expression of SEMA3E in colonic biopsies of...

journal_title：British journal of pharmacology

authors： Kermarrec L,Eissa N,Wang H,Kapoor K,Diarra A,Gounni AS,Bernstein CN,Ghia JE

更新日期：2019-05-01 00:00:00

abstract：:1. A biliary fistula was prepared in twelve sheep.2. Each animal was given 2 ml. of (14)C-carbon tetrachloride (specific activity 15 mc/m-mole) and bile collected at 2, 4, 24 and 48 hr.3. Specific activity was measured by liquid scintillation counting before and after each specimen had been heated to 75 degrees C for ...

journal_title：British journal of pharmacology

authors： Khalidi A,Zaki SA

更新日期：1969-06-01 00:00:00

abstract：:1. The present study was aimed at examining P2 receptor-mediated vasodilatation in human vessels. The isometric tension was recorded in isolated segments of the human left internal mammary artery branches precontracted with 1 microM noradrenaline. 2. Endothelial denudation abolished the dilator responses. 3. The selec...

journal_title：British journal of pharmacology

authors： Wihlborg AK,Malmsjö M,Eyjolfsson A,Gustafsson R,Jacobson K,Erlinge D

更新日期：2003-04-01 00:00:00

abstract：:1. Imidazoline binding sites have been reported to be present in the locus coeruleus (LC). To investigate the role of these sites in the control of LC neuron activity, we studied the effect of imidazolines using in vivo and in vitro single-unit extracellular recording techniques. 2. In anaesthetized rats, local (27 pm...

journal_title：British journal of pharmacology

authors： Ugedo L,Pineda J,Ruiz-Ortega JA,Martín-Ruiz R

更新日期：1998-12-01 00:00:00

abstract：:1 alpha-Flupenthixol (alpha-FPT; 0.2 mg/kg i.p.) when administered to rats produced catalepsy. 2 Baclofen (10 mg/kg i.p.) given 30 min after alpha-FPT had a biphasic effect on the catalepsy. Initially there was a potentiation of the effect, followed by a significant attenuation of the degree of catalepsy. 3 Possible m...

journal_title：British journal of pharmacology

authors： Davies JA,Williams J

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:N-type voltage-gated calcium (Cav 2.2) channels are critical determinants of increased neuronal excitability and neurotransmission accompanying persistent neuropathic pain. Although Cav 2.2 channel antagonists are recommended as first-line treatment for neuropathic pain, calcium-current blocking ...

journal_title：British journal of pharmacology

authors： Moutal A,Li W,Wang Y,Ju W,Luo S,Cai S,François-Moutal L,Perez-Miller S,Hu J,Dustrude ET,Vanderah TW,Gokhale V,Khanna M,Khanna R

更新日期：2018-06-01 00:00:00

abstract：:1 The influence of the epithelium on contractions produced by the peptidoleukotrienes, 5-hydroxytryptamine (5-HT) and the thromboxane mimetic, U-44069, was examined in trachea from control and ovalbumin-sensitized guinea-pigs. 2 In control tissues removal of the epithelium produced an approximately 2 to 4 fold leftwar...

journal_title：British journal of pharmacology

authors： Hay DW,Farmer SG,Raeburn D,Muccitelli RM,Wilson KA,Fedan JS

更新日期：1987-10-01 00:00:00

abstract：:1. The effect of several metabotropic ligands and di- or tripeptides were tested on the binding of [3H]-L(+)-2-amino-4-phosphonobutyric acid ([3H]-L-AP4) on rat mGlu4 receptor. For selected compounds, the functional activity was determined on this receptor using the guanosine-5'[gamma-35S]-thiotriphosphate [gamma-35S]...

journal_title：British journal of pharmacology

authors： Monastyrskaia K,Lundstrom K,Plahl D,Acuna G,Schweitzer C,Malherbe P,Mutel V

更新日期：1999-11-01 00:00:00

abstract：:ST-segment elevation following temporary coronary artery occlusion was measured from nine epicardial leads in open-chest anaesthetized dogs. This was greatly reduced by the prior administration of the anti-dysrhythmic aminosteroid, ORG 6001. It is suggested that this effect is related either to a reduction in the exte...

journal_title：British journal of pharmacology

authors： Marshall RJ,Parratt JR

更新日期：1977-10-01 00:00:00

abstract：:1. Ca2+ buffering function of sarcoplasmic reticulum (SR) in the resting state of arteries from spontaneously hypertensive rats (SHR) was examined. Differences in the effects of cyclopiazonic acid (CPA) and thapsigargin, agents which inhibit the Ca(2+)-ATPase of SR, on tension and cellular Ca2+ level were assessed in ...

journal_title：British journal of pharmacology

authors： Nomura Y,Asano M,Ito K,Uyama Y,Imaizumi Y,Watanabe M

更新日期：1997-01-01 00:00:00

abstract：:Inhibition of myocardial Ca2+ channels was investigated for three dihydropyridines with different structural features: Ro 18-3981, darodipine (PY 108-068) and nifedipine. Ro 18-3981 contains a sulphamoyl acetyl side-chain. In voltage-clamps experiments with isolated cardiac myocytes of guinea-pig, Ro 18-3981 caused a ...

journal_title：British journal of pharmacology

authors： Holck M,Osterrieder W

更新日期：1987-05-01 00:00:00

abstract：:1. The concentrations of adrenaline and noradrenaline in the brains of chickens (Gallus domesticus) have been determined using two different methods of fluorimetric analysis.2. The concentrations of adrenaline, noradrenaline and also dopamine were found to increase with age, as did the relative amount of adrenaline pr...

journal_title：British journal of pharmacology

authors： Callingham BA,Sharman DF

更新日期：1970-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To study the importance of endothelium-derived contracting factors (EDCFs) in arteries of rats with type I diabetes. EXPERIMENTAL APPROACH:Rat femoral arteries were collected four or twelve weeks after induction of diabetes with streptozotocin. Rings, with or without endothelium, were suspended ...

journal_title：British journal of pharmacology

authors： Shi Y,Feletou M,Ku DD,Man RY,Vanhoutte PM

更新日期：2007-03-01 00:00:00

abstract：:Photorelaxation of vascular smooth muscle (VSM) is caused by the release of nitric oxide (NO) from a finite molecular store that can be depleted by irradiating pre-contracted arteries with visible light. The ability of an 'exhausted' vessel to respond to a further period of illumination is lost temporarily but then re...

journal_title：British journal of pharmacology

authors： Megson IL,Holmes SA,Magid KS,Pritchard RJ,Flitney FW

更新日期：2000-08-01 00:00:00

abstract：:The effects of 10 mM caffeine (CAF) on intramembrane charge movements (ICM) were studied in isolated guinea-pig ventricular heart cells with the whole-cell patch-clamp technique. In the presence of CAF, the properties (voltage dependence, maximum Q(ON) [Q(max)], availability with voltage) of Q(ON) charge activated fro...

journal_title：British journal of pharmacology

authors： Leroy J,Lignon JM,Gannier F,Argibay JA,Malécot CO

更新日期：2002-02-01 00:00:00

abstract：:1. The effect of the A2A adenosine receptor agonist, 2-p-(2-carboxyethyl)phenethyl-amino-5'-N-ethylcarboxamidoadenosine (CGS 21680) on the potassium evoked release of [3H]-gamma-aminobutyric acid ([3H]-GABA) from nerve terminals derived from the caudate-putamen and the globus pallidus of the rat was compared. In both ...

journal_title：British journal of pharmacology

authors： Kurokawa M,Kirk IP,Kirkpatrick KA,Kase H,Richardson PJ

更新日期：1994-09-01 00:00:00

abstract：:1. Therapeutic doses of colistin sulphomethate sodium B.P. (Colomycin), pento-N sulphomethylpolymyxin B sodium (Thiosporin) and ampicillin B.P. (Penbritin) as well as normal saline have been given to volunteers with normal kidney function.2. A blind crossover technique was used and the effects of the compounds on bloo...

journal_title：British journal of pharmacology

authors： Caldwell AD,Martin AJ,Trigger DJ

更新日期：1969-09-01 00:00:00

abstract：:1 The specific stimulating action of dopamine and L-DOPA on exocrine pancreatic secretion was further investigated in the isolated blood-perfused canine pancreas.2 6-Hydroxydopamine (100 mug, i.a.) stimulated the secretion but was far less potent than dopamine. Epinine (0.3-1 mg. i.a.), alpha-methyldopamine (10-300 mu...

journal_title：British journal of pharmacology

authors： Furuta Y,Hashimoto K,Ishii Y,Iwatsuki K

更新日期：1974-06-01 00:00:00

abstract：:Ever increasing use of engineered carbon nanoparticles in nanopharmacology for selective imaging, sensor or drug delivery systems has increased the potential for blood platelet-nanoparticle interactions. We studied the effects of engineered and combustion-derived carbon nanoparticles on human platelet aggregation in v...

journal_title：British journal of pharmacology

authors： Radomski A,Jurasz P,Alonso-Escolano D,Drews M,Morandi M,Malinski T,Radomski MW

更新日期：2005-11-01 00:00:00

abstract：:1. Nitric oxide (NO)-mediated neurotransmission is impaired in anococcygeus muscle from 8-week streptozotocin-induced diabetic rats. This study investigated the effects of insulin treatment, and the duration of diabetes on this impairment. In addition, the effect of in vitro exposure to elevated glucose has been inves...

journal_title：British journal of pharmacology

authors： Way KJ,Reid JJ

更新日期：1995-06-01 00:00:00

abstract：:1. Rasagiline [N-propargyl-1R(+)-aminoindan], was examined for its monoamine oxidase (MAO) A and B inhibitor activities in rats together with its S(-)-enantiomer (TVP 1022) and the racemic compound (AGN-1135) and compared to selegiline (1-deprenyl). The tissues that were studied for MAO inhibition were the brain, live...

journal_title：British journal of pharmacology

authors： Youdim MB,Gross A,Finberg JP

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The adenosine 2B (A2B) receptor is the predominant adenosine receptor expressed in the colon. Acting through the A2B receptor, adenosine mediates chloride secretion, as well as fibronectin and interleukin (IL)-6 synthesis and secretion in intestinal epithelial cells. A2B receptor mRNA and protein...

journal_title：British journal of pharmacology

authors： Kolachala V,Ruble B,Vijay-Kumar M,Wang L,Mwangi S,Figler H,Figler R,Srinivasan S,Gewirtz A,Linden J,Merlin D,Sitaraman S

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Alogliptin, a highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor, enhances incretin action and pioglitazone enhances hepatic and peripheral insulin actions. Here, we have evaluated the effects of combining these agents in diabetic mice. EXPERIMENTAL APPROACH:Effects of short-term treatmen...

journal_title：British journal of pharmacology

authors： Moritoh Y,Takeuchi K,Asakawa T,Kataoka O,Odaka H

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor agonists display a promising analgesic profile in preclinical studies. However, supraspinal N/OFQ produced hyperalgesia in rodents and such effects have not been addressed in primates. Thus, the aim of this study was to investigate the effects...

journal_title：British journal of pharmacology

authors： Ding H,Hayashida K,Suto T,Sukhtankar DD,Kimura M,Mendenhall V,Ko MC

更新日期：2015-07-01 00:00:00

abstract：:The role of extracellular signal-regulated kinase (ERK)-1 and ERK-2 in controlling histamine-induced tone in bovine trachealis was investigated. PD 098059, an inhibitor of mitogen-activated protein kinase kinase (MKK)-1, had no effect on the histamine concentration-response relationship that described contraction. How...

journal_title：British journal of pharmacology

authors： Koch A,Nasuhara Y,Barnes PJ,Lindsay MA,Giembycz MA

更新日期：2000-11-01 00:00:00

abstract：:Obesity is a common metabolic disorder that has become a widespread epidemic in several countries. Sex and gender disparities in the prevalence of cardiovascular disease (CVD) have been well documented with premenopausal women having a lower incidence of CVD than age-matched men. However, women are more likely than me...

journal_title：British journal of pharmacology

authors： Taylor LE,Ramirez LA,Musall JB,Sullivan JC

更新日期：2019-11-01 00:00:00

abstract：:Some 865 genes in man encode G-protein-coupled receptors (GPCRs). The heterotrimeric guanine nucleotide-binding proteins (G-proteins) function to transduce signals from this vast panoply of receptors to effector systems including ion channels and enzymes that alter the rate of production, release or degradation of int...

journal_title：British journal of pharmacology

authors： Milligan G,Kostenis E

更新日期：2006-01-01 00:00:00

abstract：:Mitochondrial permeability transition pore (mPTP) opening plays a critical role in cardiac reperfusion injury and its prevention is cardioprotective. Tumour cell mitochondria usually have high levels of hexokinase isoform 2 (HK2) bound to their outer mitochondrial membranes (OMM) and HK2 binding to heart mitochondria ...

journal_title：British journal of pharmacology

authors： Halestrap AP,Pereira GC,Pasdois P

更新日期：2015-04-01 00:00:00