Abstract：
BACKGROUND:Therapeutic neovascularization has some obstacles, such as it requires more than one proangiogenic factor, and these factors have short half-lives. To overcome these obstacles, combined delivery of granulocyte-colony stimulating factor (G-CSF), erythropoietin (EPO) and vascular endothelial growth factor (VEGF) using protein/dextran/poly (lactic-co-glycolic acid) (PLGA) sustained-release microspheres was proposed to promote neovascularization. METHODS:Dextran microparticles loaded with G-CSF, EPO or VEGF were prepared and encapsulated in PLGA microspheres to obtain protein-dextran-PLGA microspheres. The release behavior of microspheres was studied in vitro. The protein/dextran/PLGA microspheres were injected into the ischemic hindlimbs of rats. Neovascularization in ischemic muscle was measured. RESULTS:Microspheres released G-CSF, EPO and VEGF in vitro for more than 4 weeks. Combined therapy with VEGF, EPO and G-CSF promoted the expression of B-cell lymphoma-2 and stromal cell-derived factor 1, cellular proliferation and the incorporation of C-X-C chemokine receptor 4 positive cells. Capillary density and smooth muscle α-actin+ vessel density were higher in the combined treatment of VEGF, EPO and G-CSF than in the single factor treatment. CONCLUSIONS:The combined and sustained delivery of VEGF, EPO and G-CSF using dextran-PLGA microspheres had a more significant neovascularization effect than monotherapy with each factor alone. This combined therapy might be a promising treatment for ischemic vascular diseases.
journal_name
Ann Vasc Surgjournal_title
Annals of vascular surgeryauthors
Liu CD,Tu XF,Chen Fdoi
10.1016/j.avsg.2019.10.033subject
Has Abstractpub_date
2020-04-01 00:00:00pages
328-338eissn
0890-5096issn
1615-5947pii
S0890-5096(19)30864-7journal_volume
64pub_type
杂志文章abstract：BACKGROUND:To describe a single-center experience with open surgical treatment of infected aortic aneurysms. We analyzed risk factors for 90-day mortality. METHODS:Between 1983 and 2008, 4,410 patients underwent open surgery for thoracic, thoracoabdominal, or abdominal aneurysm at our institution. Primary infection of...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2011.03.009
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:In this study we analyzed embolization and stent-graft results. METHODS:Demographics, indications, procedures, and outcomes of patients treated with embolization or stent grafting for late postoperative bleeding after major abdominal surgery were retrospectively recorded. Outcomes were analyzed on an intent...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2012.10.024
更新日期：2013-11-01 00:00:00
abstract：:Perforation of inferior vena cava (IVC) by filter struts ranges from 9% to 24%, and clinical sequelae and complications are unpredictable. The aim of this article was to report an unusual case of late complication of IVC filter that caused an IVC wall perforation and penetration of the filter's hooks in the aorta, whi...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2011.11.044
更新日期：2012-08-01 00:00:00
abstract：:Our aim was to appraise the feasibility and outcomes of subintimal angioplasty (SA) for the percutaneous revascularization of infrainguinal arterial occlusions in patients with critical limb ischemia (CLI). We retrospectively assessed 117 SA procedures in 109 limbs with complete infrainguinal occlusions from 105 patie...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2007.07.018
更新日期：2007-11-01 00:00:00
abstract：BACKGROUND:Treatment of venous ulcers is demanding for patients, as well as clinicians, and the investigation of underlying venous hypertension is the cornerstone of therapy. We propose that occult iliac vein stenosis should be ruled out by iliac vein interrogation (IVI) in patients with advanced venous stasis. METHOD...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2015.11.036
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:The aim of the study is to determine whether performing endovascular aortic aneurysm repair (EVAR) in a dedicated vascular hybrid operating room (OR) is associated with a decreased patient radiation and contrast dose compared with mobile C-arm imaging in a conventional OR. METHODS:This is a retrospective st...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2019.04.019
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:Our aim is to investigate the effect of active ankle movement to prevent deep vein thrombosis (DVT) in patients who received lower limb surgery, and to provide a theory of evidence for rehabilitation nursing of patients after orthopedic surgery. METHODS:Between January 2012 and December 2013, a total of 174...
journal_title：Annals of vascular surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.avsg.2015.10.012
更新日期：2016-04-01 00:00:00
abstract：:Performance of carotid endarterectomy for asymptomatic carotid stenosis has been restricted during recent years because of concern of reported complications in as high as 10-15% of patients, as well as limited long-term data on stroke protection. During the last 10 years, we have studied immediate and long-term result...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/BF02016741
更新日期：1991-03-01 00:00:00
abstract：:Between January 1977 and December 1990, eight patients underwent surgical correction of aneurysms of the extracranial internal carotid artery due to fibromuscular dysplasia. Mean age of patients was 50 years (range 31 to 70 years). Five patients presented with neurologic hemispheric symptoms. Most aneurysms were saccu...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/BF02000264
更新日期：1992-05-01 00:00:00
abstract：:Bronchial artery aneurysms (BAA) are a rarely noted. Asymptomatic cases of BAA are very rare. Most patients are correctly diagnosed only after BAA ruptures. The conventional treatment includes aneurysm resection through thoracotomy or transcatheter arterial embolization. In the present report, we describe a case of an...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2013.12.021
更新日期：2014-07-01 00:00:00
abstract：:Infection of aortoiliac endografts is, to date, a rare complication of endovascular surgery. Staphylococcus species are the most common responsible pathogens, just as in cases with infected grafts after open aortic surgery. We report a case of a 65-year-old man with a history of diabetes mellitus and bladder cancer wh...
journal_title：Annals of vascular surgery
pub_type： 杂志文章,评审
doi：10.1016/j.avsg.2006.05.005
更新日期：2007-03-01 00:00:00
abstract：:Resection of carotid body tumors (neck paragangliomas) carries inherent risks of injury to the cranial nerves and other structures as well excessive blood loss. Preoperative embolization has been used to lessen the morbidity in tumors that are larger than 2 cm in diameter. Two female patients presented for treatment w...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/s100160010058
更新日期：2001-03-01 00:00:00
abstract：BACKGROUND:Unintentional renal artery occlusion after endovascular aortic aneurysm repair (EVAR) is an uncommon phenomenon. The sequelae from this specific complication are severe; consequently, the topic of renal artery coverage is a pertinent issue. We present a case series of patients undergoing EVAR with unintentio...
journal_title：Annals of vascular surgery
pub_type： 杂志文章,评审
doi：10.1016/j.avsg.2012.02.018
更新日期：2012-11-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the safety, applicability and outcomes of the endovascular in situ fenestration (ISF) technique for patients with aortic arch pathologies by performing a systematic review. METHODS:We conducted a systematic search using the PubMed, Embase, and Cochrane databases to ident...
journal_title：Annals of vascular surgery
pub_type： 杂志文章,评审
doi：10.1016/j.avsg.2020.12.021
更新日期：2021-01-25 00:00:00
abstract：BACKGROUND:This study evaluates differences in wound complication rate when transverse versus longitudinal incision is utilized to expose femoral vessels in managing patients with peripheral vascular disease. METHODS:A retrospective review from 2013 to 2015 was conducted of 150 patients undergoing 156 lower extremity ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2017.08.019
更新日期：2018-02-01 00:00:00
abstract：:Most physicians are aware of the important role that platelets play in thrombus formation. The mechanisms that regulate platelet function are now understood at the molecular level. The same biologic processes that control platelet participation in the hemostatic process also allow platelets to interact with the vessel...
journal_title：Annals of vascular surgery
pub_type： 杂志文章,评审
doi：10.1007/BF02001017
更新日期：1993-03-01 00:00:00
abstract：BACKGROUND:Venous valvular reflux is the main cause of chronic venous dysfunction. However, the etiology of valvular reflux is not completely understood. We conducted this study to investigate new risk factors for venous reflux of the great saphenous vein (GSV) in the thigh. METHODS:We studied 139 consecutive patients...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2017.05.004
更新日期：2017-10-01 00:00:00
abstract：:Aortic iatrogenic injuries during spinal instrumentation are rare but carry a high risk of mortality. In this report, we describe the case of a 26-year-old man with traumatic vertebral fracture and subsequent spinal cord injury who underwent posterior vertebral fixation at our trauma center. The neurosurgical procedur...
journal_title：Annals of vascular surgery
pub_type：
doi：10.1016/j.avsg.2020.01.007
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:Postoperative ischemic colitis (POIC) remains a frequent and extremely severe complication of infrarenal abdominal aorta surgery. However, its diagnosis and treatment are not always consensual because the incidence is very small. The aim of this retrospective study was to evaluate the prognostic factors of s...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2010.02.054
更新日期：2011-07-01 00:00:00
abstract：:The hemodynamic effects of combined venoarterial injury and stasis were studied in the hindlimbs of 10 dogs. Femoral arterial blood flow and pressure, peripheral venous pressure, and peripheral resistance were measured after the restoration of blood flow following venoarterial injury and a 4-hour period of occlusion f...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/BF02018865
更新日期：1994-03-01 00:00:00
abstract：BACKGROUND:Lymphatic interventions have recently been increasingly used for treating lymphatic leak of the abdomen and pelvis. This retrospective case study series and systematic review evaluated the efficacy and safety of lymphatic interventions for the treatment of postoperative lymphatic leak of the abdomen and pelv...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2020.04.063
更新日期：2020-10-01 00:00:00
abstract：:Situs inversus is a rare congenital defect defined by a mirror image anatomic variation of the thoracic and abdominal organs. In this situation, abdominal aortic surgery may become particularly challenging. This is the case of a 51-year-old man, who presented with an incapacitating lower limb claudication. On his work...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2015.02.023
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Basilic vein transposition via single long incision is a renowned technique despite its known wound-related complications. Contrary to that, multiple skip incisions technique is thought to have relatively lower wound-related complications. But to the best of our knowledge, these 2 techniques have never been ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2018.01.083
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Pregnancy is a hypercoagulable state associated with a fivefold increase in the risk of venous thromboembolism. Thrombolysis is the preferred level of care for patients with acute iliofemoral deep vein thrombosis (DVT); however, most studies exclude pregnant patients, highlighting the lack of data regarding ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2019.01.018
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:We investigated the outcome of vein stenting placement for chronic proximal venous outflow obstruction (PVOO) in a predominantly Asian-American cohort to improve patient selection, enhance technical approach, and better define quality measurements of this emerging vascular intervention. METHODS:A total of 4...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2020.01.018
更新日期：2020-07-01 00:00:00
abstract：:The long-term impact of retroperitoneal aortic exposure regarding wound complications in all patients and erectile dysfunction in men was studied in a consecutive group of 107 patients (81 males and 26 females). Postoperative wound complications were classified into the following groups: none, flank bulge, hernia, and...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/s10016-006-9014-2
更新日期：2006-03-01 00:00:00
abstract：:OMNEX (Ethicon, Inc.; Somerville, NJ) is a cyanoacrylate-based synthetic surgical sealant. To date, the use of OMNEX has only been described in a limited number of vascular surgery procedures. We present the cases of two patients who underwent successful extracorporeal renal artery aneurysm repair with the aid of OMNE...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2011.07.009
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:Noninvasive diagnostic testing may be beneficial to identify stenotic (failing) stents placed for occlusive lower extremity peripheral arterial disease (LEPAD), especially if subsequent intervention proves useful in maintaining prolonged stent patency. We previously documented the benefit of surveillance dup...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2019.08.086
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Several clinical and epidemiological studies describe hyperhomocysteinemia as an independent cardiovascular risk factor. Implication of cellular immunity in atherosclerosis also seems clear. This study aimed to analyze the association among plasma hyperhomocysteinemia, neurological clinical events, and the m...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2011.05.047
更新日期：2012-05-01 00:00:00
abstract：:Iliac artery aneurysms are rare in the absence of concomitant abdominal aortic aneurysm (AAA), and isolated internal iliac (hypogastric) aneurysms in particular are extremely rare. From 1986 to 1997 we repaired 572 aortic and/or iliac artery aneurysms in 440 patients. Among these there were only seven hypogastric aneu...
journal_title：Annals of vascular surgery
pub_type： 杂志文章,评审
doi：10.1007/s100169900296
更新日期：1999-09-01 00:00:00
