The Role of Animal Models in Elucidating the Etiology and Pathology of Abdominal Aortic Aneurysms: Development of a Novel Rupture Mechanism Model.

Abstract:

:Existing animal models do not replicate all aspects of abdominal aortic aneurysms (AAAs), including the rupture mechanisms. From histopathological analyses conducted in humans, it has been found that the vasa vasorum of the AAA wall is the starting point of circulatory failure and that bulging and dilatation of the abdominal aorta occurs through inflammation and tissue degeneration. We created a new animal model (the hypoperfusion-induced model) of AAAs. In this study, we describe the current animal models of AAAs and present the utility of our new model of AAAs.

journal_name

Ann Vasc Surg

authors

Tanaka H,Zaima N,Kugo H,Yata T,Iida Y,Hashimoto K,Miyamoto C,Sasaki T,Sano H,Suzuki Y,Moriyama T,Shimizu H,Inuzuka K,Urano T,Unno N

doi

10.1016/j.avsg.2019.08.082

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

382-390

eissn

0890-5096

issn

1615-5947

pii

S0890-5096(19)30761-7

journal_volume

63

pub_type

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