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Steady and pulsatile flow fields in an end-to-side arterial anastomosis model.

Abstract：

:We investigated the flow field within a rigid-walled in vitro model of an end-to-side 45 degree anastomosis in an attempt to identify possible hemodynamic factors that may contribute to the pathogenesis of distal anastomotic intimal hyperplasia. A high-resolution photochromic tracer technique was used to visualize the flow in orthogonal planes and to determine the axial wall shear stress profiles for both steady and pulsatile flows over a range of physiologically relevant conditions. The flow field showed qualitative similarities to those seen in curved vessel: rapidly moving fluid from the graft section affects the bed of the host vessel, that is, the wall opposite the anastomosis, eventually advancing down the host vessel in a spiraling motion. A small mobile separation zone was noted at the toe of the anastomosis. Comparison of wall shear stress profiles with previously reported preferential sites for the development of intimal hyperplasia supported a low wall shear stress and/or flow separation pathogenesis hypothesis. One notable exception was the bed of the host artery that appeared to be subjected to a complex hemodynamic environment.

journal_name

J Vasc Surg

journal_title

Journal of vascular surgery

authors

Ojha M,Ethier CR,Johnston KW,Cobbold RS

doi

10.1067/mva.1990.24365

subject

Has Abstract

pub_date

1990-12-01 00:00:00

pages

747-53

issue

6

eissn

0741-5214

issn

1097-6809

pii

0741-5214(90)70014-E

journal_volume

12

pub_type

杂志文章

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