Zmpste24-/- mouse model for senescent wound healing research.

Abstract:

BACKGROUND:The graying of our population has motivated the authors to better understand age-related impairments in wound healing. To increase research throughput, the authors hypothesized that the Hutchinson-Gilford progeria syndrome Zmpste24-deficient (Zmpste24(-/-)) mouse could serve as a model of senescent wound healing. METHODS:Using a stented excisional wound closure model, the authors tested this hypothesis on 8-week-old male Zmpste24(-/-) mice (n = 25) and age-matched male C57BL/6J wild-type mice (n = 25). Wounds were measured photogrammetrically and harvested for immunohistochemistry, enzyme-linked immunosorbent assay, and quantitative real-time polymerase chain reaction, and circulating vasculogenic progenitor cells were measured by flow cytometry. RESULTS:Zmpste24(-/-) mice had a significant delay in wound closure compared with wild-type mice during the proliferative/vasculogenic phase. Zmpste24(-/-) wounds had decreased proliferation, increased 8-hydroxy-2'-deoxyguanosine levels, increased proapoptotic signaling (i.e., p53, PUMA, BAX), decreased antiapoptotic signaling (i.e., Bcl-2), and increased DNA fragmentation. These changes correlated with decreased local vasculogenic growth factor expression, decreased mobilization of bone marrow-derived vasculogenic progenitor cells, and decreased new blood vessel formation. Age-related impairments in wound closure are multifactorial. CONCLUSIONS:The authors' data suggest that the Hutchinson-Gilford progeria syndrome Zmpste24(-/-) progeroid syndrome shares mechanistic overlap with normal aging and therefore might provide a uniquely informative model with which to study age-associated impairments in wound closure.

journal_name

Plast Reconstr Surg

authors

Butala P,Szpalski C,Soares M,Davidson EH,Knobel D,Warren SM

doi

10.1097/PRS.0b013e31826d102b

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

788e-798e

issue

6

eissn

0032-1052

issn

1529-4242

pii

00006534-201212000-00008

journal_volume

130

pub_type

杂志文章
  • Reconstruction of oncologic tibial defects in children using vascularized fibula flaps.

    abstract:BACKGROUND:Tibial resection in children presents a unique reconstructive challenge because of technical demands, future growth potential, and repetitive loading of the lower extremity. Positioned in a tibial defect, the free fibula undergoes primary bone healing while maintaining intrinsic resistance to infection and t...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e318230e463

    authors: Schwarz GS,Disa JJ,Mehrara BJ,Healey JH,Cordeiro PG

    更新日期:2012-01-01 00:00:00

  • Mitochondrial activity of orbicularis oris muscle in unilateral cleft lip patients.

    abstract::To better evaluate the role of a possible mitochondrial alteration in the pathogenesis of cleft lip, we obtained and examined 38 orbicularis oris muscle specimens taken from the cleft margin of both cleft and noncleft sides of 10 unilateral cleft lip infants at the time of primary closure. Part of each sample was froz...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199809040-00005

    authors: Raposio E,Bado M,Verrina G,Santi P

    更新日期:1998-09-01 00:00:00

  • The differing effects of isoxsuprine on muscle flap and skin flap survival in the pig.

    abstract::The pretreatment of pigs with isoxsuprine for two weeks resulted in a significant increase in the surviving length of sartorius muscle flaps when compared with untreated flaps on the same animal. However, there was no improvement in the surviving length of neurovascular island skin flaps when these animals were treate...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:

    authors: Cherry GW

    更新日期:1979-11-01 00:00:00

  • Prepectoral Breast Reconstruction in the Setting of Postmastectomy Radiation Therapy: An Assessment of Clinical Outcomes and Benefits.

    abstract:BACKGROUND:Prepectoral breast reconstruction following mastectomy has become a more widely performed technique in recent years because of its numerous benefits for women. These include full pectoralis muscle preservation, reduced loss of strength, reduced pain, and elimination of animation deformity. As with any breast...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000005140

    authors: Sbitany H,Gomez-Sanchez C,Piper M,Lentz R

    更新日期:2019-01-01 00:00:00

  • Use of a Waterproof Camera Immersed in Povidone-Iodine to Improve Intraoperative Photography.

    abstract::Intraoperative photography has the potential to raise costs and introduce possible contamination but is essential for documentation in plastic surgery. The authors evaluate their use of a waterproof camera immersed in povidone-iodine for taking intraoperative photographs in an efficient manner. A waterproof camera is ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000005327

    authors: Purnell CA,Alkureishi LWT,Koranda C,Patel PK

    更新日期:2019-03-01 00:00:00

  • Morphologic study of mandibular outer cortex osteotomy.

    abstract:BACKGROUND:The purpose of this study was to illustrate the morphologic changes of the mandible after outer cortex osteotomy. METHODS:Ten patients had undergone mandibular outer cortex osteotomy. By using the true-up and dissection techniques based on three-dimensional spiral computed tomography, variables of effect an...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181845951

    authors: Zhao YF,Liu XJ,Hao YF,Lu P,Gui L

    更新日期:2008-10-01 00:00:00

  • Botox therapy for ischemic digits.

    abstract:BACKGROUND:Treating patients with Raynaud's phenomenon who have chronic pain and ulcerations is extremely challenging. Unrelenting pain can lead to dysfunction and disuse, rendering the patient debilitated and/or chronically depressed. Pharmacologic vasodilators and surgical sympathectomies offer variable benefits. Out...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181a80576

    authors: Neumeister MW,Chambers CB,Herron MS,Webb K,Wietfeldt J,Gillespie JN,Bueno RA Jr,Cooney CM

    更新日期:2009-07-01 00:00:00

  • Direct-to-Implant Breast Reconstruction without the Use of an Acellular Dermal Matrix Is Cost Effective and Oncologically Safe.

    abstract:BACKGROUND:Direct-to-implant breast reconstruction is a predictable, reliable, and cost-effective reconstruction. Most units performing direct-to-implant reconstructions recommend the use of an acellular dermal matrix or a mesh to reinforce the lower pole of the breast reconstruction. METHODS:Two hundred seventy-two c...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000003222

    authors: Serrurier LCJ,Rayne S,Venter M,Benn CA

    更新日期:2017-04-01 00:00:00

  • Septum-based mammaplasty: a surgical technique based on Würinger's septum for breast reduction.

    abstract:BACKGROUND:During the past 7 years, the senior author (M.H.) has been performing septum-based mammaplasty. The aim of this article is to report the safety and ease of breast shaping by using this technique. METHODS:A series of 110 consecutive patients underwent septum-based breast reduction performed by a single surge...

    journal_title:Plastic and reconstructive surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/PRS.0b013e318196b852

    authors: Hamdi M,Van Landuyt K,Tonnard P,Verpaele A,Monstrey S

    更新日期:2009-02-01 00:00:00

  • Breast reconstruction with the latissimus dorsi flap: women's preference for scar location.

    abstract:BACKGROUND:Refinements made in latissimus dorsi breast reconstruction have improved the aesthetic appearance of the breast without changing the donor-site location. The optimal location for donor-site placement, from a patient's perspective, is still unknown. The purpose of this study was to assess women's preference f...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181de1b41

    authors: Bailey S,Saint-Cyr M,Zhang K,Mojallal A,Wong C,Ouyang D,Maia M,Zhang S,Rohrich RJ

    更新日期:2010-08-01 00:00:00

  • Supraclavicular artery island flap for head and neck oncologic reconstruction: indications, complications, and outcomes.

    abstract:BACKGROUND:The supraclavicular island flap has been used successfully for difficult facial reconstruction cases, providing acceptable results without using microsurgical techniques. The authors use this regional flap in reconstructing various head and neck oncologic defects that normally require traditional regional or...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181aa0e5d

    authors: Chiu ES,Liu PH,Friedlander PL

    更新日期:2009-07-01 00:00:00

  • Immature versus mature dura mater: II. Differential expression of genes important to calvarial reossification.

    abstract::The ability of immature animals and newborns to orchestrate successful calvarial reossification is well described. This capacity is markedly attenuated in mature animals and in humans greater than 2 years of age. Previous studies have implicated the dura mater as critical to successful calvarial reossification. The au...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:

    authors: Greenwald JA,Mehrara BJ,Spector JA,Fagenholz PJ,Saadeh PB,Steinbrech DS,Gittes GK,Longaker MT

    更新日期:2000-09-01 00:00:00

  • Grafting the alar rim: application as anatomical graft.

    abstract:BACKGROUND:Alar rim contour and alar rim grafts have become essential components of rhinoplasty. Ideally, grafts of the nose should be anatomical in shape. So doing might make grafts of the alar rim more robust. The authors considered doing that by applying the graft as a continuous extension of the lateral crus. METH...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000000764

    authors: Gruber RP,Fox P,Peled A,Belek KA

    更新日期:2014-12-01 00:00:00

  • A Growing Epidemic: Plastic Surgeons and Burnout-A Literature Review.

    abstract:BACKGROUND:The prevalence of burnout is increasing among all physicians, including plastic surgeons. Burnout is not simply synonymous with being overworked. It is a complex physical, intellectual, and psychological entity that arises when the expectation and reality of the job do not match. In this article, the authors...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/PRS.0000000000005875

    authors: Khansa I,Janis JE

    更新日期:2019-08-01 00:00:00

  • Evidence-Based Medicine: Wound Closure.

    abstract:LEARNING OBJECTIVES:After reading this article, the participant should be able to: 1. Describe various wound closure techniques available to the modern plastic surgeon, including the indications and contraindications of each. 2. Explain the fundamental concepts of wound healing as it relates to reconstruction. 3. Under...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/PRS.0000000000002775

    authors: Buchanan PJ,Kung TA,Cederna PS

    更新日期:2016-09-01 00:00:00

  • Recombinant human bone morphogenetic protein-2-induced craniosynostosis and growth restriction in the immature skeleton.

    abstract:BACKGROUND:Recombinant human bone morphogenetic protein-2 (rhBMP-2) delivered on an absorbable collagen sponge is a U.S. Food and Drug Administration-approved therapy effective at generating bone formation. In pediatric patients for whom other therapeutic options have been exhausted, rhBMP-2 is used off-label to addres...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e318205f2b4

    authors: Kinsella CR Jr,Cray JJ,Durham EL,Burrows AM,Vecchione L,Smith DM,Mooney MP,Cooper GM,Losee JE

    更新日期:2011-03-01 00:00:00

  • Congenital bifid sternum: repair in early infancy and literature review.

    abstract::Sternal clefting is an unusual congenital anomaly that should be repaired in early infancy. Early surgery is facilitated by a highly compliant bony thorax. The surgical technique is described, including the (1) removal of a wedge at the confluence of the two lateral sternal bands to allow their apposition, (2) intraop...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:

    authors: Greenberg BM,Becker JM,Pletcher BA

    更新日期:1991-11-01 00:00:00

  • The biophysics of mandibular fractures: an evolution toward understanding.

    abstract:BACKGROUND:Predicting outcomes based on a variety of fixation techniques remains problematic in the treatment of mandible fractures. There is inherent difficulty in comparing the hundreds of published articles on the subject because of the large number of variables, including injury patterns, assessment techniques, tre...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/01.prs.0000297646.86919.b7

    authors: Rudderman RH,Mullen RL,Phillips JH

    更新日期:2008-02-01 00:00:00

  • Teaching plastic surgery from different perspectives.

    abstract::Just as everyone has a different learning style, teachers too approach the task from different perspectives. There are five basic teaching perspectives or styles: transmission, apprenticeship, developmental, nurturing, and social justice. The acronym BIAS is useful to describe the beliefs, intentions, assessments, and...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e318252f182

    authors: Cable C,Chong T,Pratt DD

    更新日期:2012-06-01 00:00:00

  • Arteriovenous vascular loops in free flap reconstruction of the extremities.

    abstract:BACKGROUND:High-energy trauma or peripheral arteriopathy may render recipient vessels unsuitable for free tissue transfer. Vein grafts can be used to lengthen the vascular pedicles to reach healthy distant vessels but with an increased complication rate. METHODS:From 1995 to 2006, 56 arteriovenous loops were construct...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000297634.53915.e5

    authors: Cavadas PC

    更新日期:2008-02-01 00:00:00

  • The MCFONTZL classification system for soft-tissue injuries to the face.

    abstract::A review of the literature and case records reflected a need for the development of a clinically applicable assessment scheme and classification system for soft-tissue laceration injuries to the face. Herein, a systematic approach for assessing facial lacerations is proposed based on location, depth of penetration, br...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199904040-00008

    authors: Lee RH,Gamble WB,Robertson B,Manson PN

    更新日期:1999-04-01 00:00:00

  • Long-term effect on donor sites after components separation: a radiographic analysis.

    abstract:BACKGROUND:The long-term implications of components separation for the lateral oblique and rectus muscles remain unknown. The authors hypothesized that recreation of the tendinous insertion of the linea alba through components separation results in expansion of the rectus muscle with potential atrophy of the external o...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3182589d79

    authors: Hicks CW,Krpata DM,Blatnik JA,Novitsky YW,Rosen MJ

    更新日期:2012-08-01 00:00:00

  • Subfascial breast implant: a new procedure.

    abstract::Breast augmentation techniques using the submuscular and subglandular planes to introduce the implant are well known and widely used procedures. The authors have been using the subfascial dissection plane, a new concept for breast augmentation. From October of 1998 to September of 2001, 263 patients underwent breast a...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.PRS.0000041601.59651.15

    authors: Graf RM,Bernardes A,Rippel R,Araujo LR,Damasio RC,Auersvald A

    更新日期:2003-02-01 00:00:00

  • The use of alloplastic materials in rhinoplasty surgery: a meta-analysis.

    abstract:BACKGROUND:Conventional wisdom regarding the use of alloplastic materials in rhinoplastic surgery would advise against their use because of safety and aesthetic concerns. However, autogenous tissue harvest is not without associated morbidity and may be inadequate or insufficient in some clinical situations. Prior studi...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,meta分析

    doi:10.1097/01.prs.0000299386.73127.a7

    authors: Peled ZM,Warren AG,Johnston P,Yaremchuk MJ

    更新日期:2008-03-01 00:00:00

  • Megavolume autologous fat transfer: part II. Practice and techniques.

    abstract::The authors describe the techniques that use the principles of fat grafting to allow them to successfully graft megavolumes (250-ml range) of autologous fat into breasts. The Brava external volume expansion device preoperatively increases the volume and vascularity of the recipient site. Low-pressure liposuction and m...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000000179

    authors: Khouri RK,Rigotti G,Cardoso E,Khouri RK Jr,Biggs TM

    更新日期:2014-06-01 00:00:00

  • Osteogenesis in calvarial defects: contribution of the dura, the pericranium, and the surrounding bone in adult versus infant animals.

    abstract::Guided bone regeneration is a promising means for reconstructing bone defects in the cranium. The present study was performed to better define those factors that affect osteogenesis in the cranium. The authors studied a single animal model, investigating the contribution of the dura, the pericranium, and the adjacent ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.PRS.0000070728.56716.51

    authors: Gosain AK,Santoro TD,Song LS,Capel CC,Sudhakar PV,Matloub HS

    更新日期:2003-08-01 00:00:00

  • Metopic synostosis: evaluation of aesthetic results.

    abstract::Analysis of intermediate- and long-term results of surgical treatment of metopic synostosis is lacking. We therefore retrospectively studied 23 patients with metopic synostosis (14 males, 9 females) who have been followed from 3 months to 8.1 years (mean 42.5 months) after operation. Age at first operation ranged from...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:

    authors: Cohen SR,Maher H,Wagner JD,Dauser RC,Newman MH,Muraszko KM

    更新日期:1994-11-01 00:00:00

  • Clinical applications of the subgaleal fascia.

    abstract::The anatomic boundaries and vascular supply of the subgaleal fascia have been described previously. The thin and malleable subgaleal fascia was selected for difficult reconstructive problems in seven patients. This flap has been based on either the supraorbital or the superficial temporal vascular leash. The subgaleal...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199104000-00003

    authors: Carstens MH,Greco RJ,Hurwitz DJ,Tolhurst DE

    更新日期:1991-04-01 00:00:00

  • Three- and four-dimensional computed tomography angiographic studies of commonly used abdominal flaps in breast reconstruction.

    abstract:BACKGROUND:The innovative technique of three- and four-dimensional computed tomographic angiography allows us to analyze the areas of perfusion in commonly used free abdominal flaps in breast reconstruction, such as pedicled transverse rectus abdominis musculocutaneous (TRAM) flaps, full TRAMs, muscle-sparing TRAMs, an...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181aa0db8

    authors: Wong C,Saint-Cyr M,Arbique G,Becker S,Brown S,Myers S,Rohrich RJ

    更新日期:2009-07-01 00:00:00

  • Structural fat grafting: more than a permanent filler.

    abstract::Grafted fat has many attributes of an ideal filler, but the results, like those of any procedure, are technique dependent. Fat grafting remains shrouded in the stigma of variable results experienced by most plastic surgeons when they first graft fat. However, many who originally reported failure eventually report succ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000234610.81672.e7

    authors: Coleman SR

    更新日期:2006-09-01 00:00:00