Abstract:
:This clinical investigation was designed to characterize the pharmacologic response to theophylline in elderly individuals. Incremental theophylline plasma concentrations (0, 5, 10, 15, and 20 mcg/mL), achieved through dose escalation of intravenous aminophylline, were correlated with pulmonary airway responses in ten young and ten elderly male asthmatic volunteers. The older group had lower baseline pulmonary function values, suggestive of a greater degree of baseline airways obstruction. Despite wide intersubject variability, the elderly subjects demonstrated a lower absolute change in bronchodilator response to equal concentrations of theophylline than did their younger counterparts (P less than .05). A progressive increase in heart rate was noted with increasing theophylline concentrations, but no significant difference in heart rate change between groups was detected (P greater than .05). Whether the difference in theophylline induced bronchodilator response observed in the young and elderly groups is due to a difference in age or in severity of airway obstruction is yet unknown.
journal_name
J Clin Pharmacoljournal_title
Journal of clinical pharmacologyauthors
Chandler MH,Clifton GD,Burki NK,Hunt BA,Blouin RAdoi
10.1002/j.1552-4604.1990.tb03602.xsubject
Has Abstractpub_date
1990-04-01 00:00:00pages
330-5issue
4eissn
0091-2700issn
1552-4604journal_volume
30pub_type
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journal_title:Journal of clinical pharmacology
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