Effects of Biliopancreatic Diversion on Bone Turnover Markers and Association with Hormonal Factors in Patients with Severe Obesity.


BACKGROUND:This study evaluated early and medium-term changes in bone turnover markers, and their associations with weight loss, total bone mineral density (BMD), and hormonal changes after biliopancreatic diversion (BPD). METHODS:Ancillary study from a one-year prospective cohort of 16 individuals assessed before, 3 days, 3 and 12 months after BPD. Bone turnover markers (C-terminal telopeptide (CTX), intact osteocalcin (OC), sclerostin, and osteoprotegerin (OPG)) and several hormones were measured at each visit. Total BMD by DXA was assessed at baseline, 3 and 12 months after BPD. Three participants were lost to follow-up. RESULTS:CTX increased significantly at 3 days (+ 66%), 3 months (+ 219%), and 12 months (+ 295%). OC decreased at 3 days (- 19%) then increased at 3 months (+ 69%) and 12 months (+ 164%). Change in sclerostin was only significant between 3 days and 3 months (+ 13%), while change in OPG was significant between baseline and 3 days (+ 48%) and baseline and 12 months (+ 45%). CTX increase correlated negatively with weight loss at 3 (r = - 0.63, p = 0.009) and 12 months (r = - 0.58, p = 0.039), and total BMD decrease (r = - 0.67, p = 0.033) at 12 months. Change in insulin and adiponectin correlated with changes in bone turnover markers independently of weight loss. CONCLUSION:BPD causes an earlier and greater increase in bone resorption over bone formation markers and a decrease in total BMD. Sclerostin did not increase as expected following extensive weight loss. Changes in insulin and adiponectin seem to play a role in the activation of bone remodeling after BPD.


Obes Surg


Obesity surgery


Turcotte AF,Grenier-Larouche T,Ung RV,Simonyan D,Carreau AM,Carpentier AC,Mac-Way F,Michou L,Tchernof A,Biertho L,Lebel S,Marceau S,Gagnon C




Has Abstract


2019-03-01 00:00:00














  • Effect of a high fat diet on quantitative features of adipocytes in the omentum: an experimental, stereological and ultrastructural study.

    abstract:BACKGROUND:Omental adipose tissue specimens of female rats that were fed a high fat (HF) diet were evaluated stereologically and histopathologically. To our knowledge, there is no stereological study on numerical density, nuclear height and volume of adipocytes in omental adipose tissue in the female rat fed a HF diet ...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Aslan H,Altunkaynak BZ,Altunkaynak ME,Vuraler O,Kaplan S,Unal B

    更新日期:2006-11-01 00:00:00

  • Delayed Intra Splenic Abscess: a Specific Complication Following Laparoscopic Sleeve Gastrectomy.

    abstract:BACKGROUND:Delayed intra splenic abscess after laparoscopic sleeve gastrectomy (LSG) is a very rare complication with poor manifestations. METHODS:We present three cases of delayed intrasplenic abscess which were managed in our departmentof minimal invasive surgery. DISCUSSION:Splenic abscess may occur in the early p...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Nassour F,Schoucair NM,Tranchart H,Maitre S,Dagher I

    更新日期:2018-02-01 00:00:00

  • A Cross-sectional Study of Reported Exercise and Medium-Term Weight Loss Following Laparoscopic Bariatric Surgery.

    abstract:BACKGROUND:Exercise is a strong determinant of prolonged weight loss in non-surgical patients. Studies evaluating the impact of exercise beyond the first year after bariatric surgery are lacking. We analyzed the relationship between reported intentional exercise and medium-term weight loss following bariatric surgery. ...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Kerrigan DJ,Carlin AM,Munie S,Keteyian SJ

    更新日期:2018-12-01 00:00:00

  • Sleeve Gastrectomy Reversed Obesity-Induced Hypogonadism in a Rat Model by Regulating Inflammatory Responses in the Hypothalamus and Testis.

    abstract:BACKGROUND:Obesity is a metabolic disease with a serious health burden in children and adults, and it induces a variety of conditions including subfecundity. Sleeve gastrectomy showed encouraging results in terms of weight loss and improve quality of life, and this study aimed to determine whether sleeve gastrectomy co...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Xiang J,Bian C,Wan X,Zhang Q,Huang S,Wu D

    更新日期:2018-08-01 00:00:00

  • Relation of childhood sexual abuse and other forms of maltreatment to 12-month postoperative outcomes in extremely obese gastric bypass patients.

    abstract:BACKGROUND:The prognostic significance of sexual abuse for extremely obese patients who undergo bariatric surgery is uncertain. This study examined self-reported childhood sexual abuse and other forms of childhood maltreatment in relation to preoperative presentation and to 12-month postoperative outcomes in gastric by...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Grilo CM,White MA,Masheb RM,Rothschild BS,Burke-Martindale CH

    更新日期:2006-04-01 00:00:00

  • Validity and Clinical Utility of Subtyping by the Beck Depression Inventory in Women Seeking Gastric Bypass Surgery.

    abstract:BACKGROUND:The Beck Depression Inventory (BDI) is commonly used in the screening and evaluation process with bariatric surgery candidates despite relatively limited psychometric evidence in this patient group. We examined the validity of the BDI and its clinical utility for subtyping women seeking gastric bypass surger...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Ivezaj V,Barnes RD,Grilo CM

    更新日期:2016-09-01 00:00:00

  • Monitoring of Liver Function Tests after Roux-en-Y Gastric Bypass: An Examination of Evidence Base.

    abstract::There is no consensus on the monitoring of liver function tests after Roux-en-Y gastric bypass (RYGB). Since the main objective of such monitoring would be to diagnose early those who will eventually develop liver failure after RYGB, we performed a systematic review on this topic. An extensive search of literature rev...

    journal_title:Obesity surgery

    pub_type: 杂志文章,评审


    authors: Mahawar KK,Parmar C,Graham Y,De Alwis N,Carr WR,Jennings N,Small PK

    更新日期:2016-10-01 00:00:00

  • Options in Bariatric Surgery: Modeled Decision Analysis Supports One-Anastomosis Gastric Bypass as the Treatment of Choice when Type 2 Diabetes Is Present.

    abstract:BACKGROUND:Obesity and type 2 diabetes mellitus (T2DM) represent significant healthcare burdens. Surgical management is superior to traditional medical therapy. Laparoscopic sleeve gastrectomy (LSG) and gastric bypass (both Roux-en-Y (RYGB) and one anastomosis gastric bypass (OAGB) are the most commonly performed metab...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Brosnan C,Bolger JC,Bolger EM,Kelly ME,Tully R,AlAzzawi M,Robb WB

    更新日期:2020-12-01 00:00:00

  • A meta-analysis: to compare the clinical results between gastric bypass and sleeve gastrectomy for the obese patients.

    abstract::We attempted to compare the effects of two kinds of surgery for obesity: laparoscopic gastric bypass (LGB) and laparoscopic sleeve gastrectomy (LSG). We performed an electronic literature search of published articles relating to obesity surgery since inception to July 2012, in which LGB was compared with LSG for patie...

    journal_title:Obesity surgery

    pub_type: 杂志文章,meta分析


    authors: Yang X,Yang G,Wang W,Chen G,Yang H

    更新日期:2013-07-01 00:00:00

  • Small Intestinal Length Associates with Serum Triglycerides Before and After LRYGB.

    abstract:BACKGROUND AND AIMS:Different bariatric procedures have been associated with variable weight loss and decrease in serum levels of lipids and lipoproteins. This variation could be partly related to the length of the small intestinal bypass. We evaluated the association of the small intestinal length with the non-alcohol...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Käkelä P,Männistö V,Vaittinen M,Venesmaa S,Kärjä V,Virtanen K,Paajanen H,Pihlajamäki J

    更新日期:2018-12-01 00:00:00

  • Relationship Between Diet and Body Composition After Biliopancreatic Diversion.

    abstract:BACKGROUND:Biliopancreatic diversion (BPD) has been shown to be one of the most effective techniques for losing weight, although the relationship between body composition and diet after the procedure is not well known. Our aim was to assess dietary changes and their effects on body composition. METHODOLOGY:This longit...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Calleja-Fernández A,Pintor-de-la-Maza B,Diez-Rodríguez R,Vidal-Casariego A,Urioste-Fondo A,Cano-Rodríguez I,Ballesteros-Pomar MD

    更新日期:2015-11-01 00:00:00

  • Optimization of access-port placement for the lap-band system.

    abstract:BACKGROUND:The technical aspects of access-port (AP) placement are not generally described in Lap-Band series. METHODS:From November 2000 to April 2002, we performed Lap-Band procedures laparoscopically on 180 patients. A retrospective review was conducted of 3 consecutive AP-placement techniques in nonselected and de...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Spivak H,Gold D,Guerrero C

    更新日期:2003-12-01 00:00:00

  • Impact of Bariatric Surgery on Metabolic and Gut Microbiota Profile: a Systematic Review and Meta-analysis.

    abstract::We aim to review the available literature on obese patients treated with bariatric procedures, in order to assess their effect on the metabolic and gut microbiota profiles. A systematic literature search was performed in PubMed, Cochrane library, and Scopus databases, in accordance with the PRISMA guidelines. Twenty-t...

    journal_title:Obesity surgery

    pub_type: 杂志文章,meta分析,评审


    authors: Magouliotis DE,Tasiopoulou VS,Sioka E,Chatedaki C,Zacharoulis D

    更新日期:2017-05-01 00:00:00

  • Prospective Assessment of Postoperative Nausea Early After Bariatric Surgery.

    abstract:BACKGROUND:The most common reason for readmission after bariatric surgery is postoperative nausea and vomiting (PONV). The aim of this study was to compare the incidence and severity of PONV between patients undergoing laparoscopic sleeve gastrectomy (SG) and gastric bypass (GB). METHODS:This was a prospective observa...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Celio A,Bayouth L,Burruss MB,Spaniolas K

    更新日期:2019-03-01 00:00:00

  • Port complications following laparoscopic adjustable gastric banding for morbid obesity.

    abstract:BACKGROUND:Laparoscopic adjustable gastric banding (LAGB) has gained widespread acceptance. However, the technique has problems intrinsic to the material wear and tear around the port and connecting tubing that can lead to failure. Port complications are considered to be minor; however, few studies have analyzed them, ...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Keidar A,Carmon E,Szold A,Abu-Abeid S

    更新日期:2005-03-01 00:00:00

  • Nutrient Deficiency 10 Years Following Roux-en-Y Gastric Bypass: Who's Responsible?

    abstract:OBJECTIVE(S):Monitoring and prevention of long-term nutrient deficiency after laparoscopic Roux-en-Y gastric bypass (LRYGB) remains ill defined due to limited surgical follow-up after bariatric surgery. This study compared nutrient supplementation as well as surgeon and primary care physician (PCP) follow-up between pa...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Mehaffey JH,Mehaffey RL,Mullen MG,Turrentine FE,Malin SK,Schirmer B,Wolf AM,Hallowell PT

    更新日期:2017-05-01 00:00:00

  • Difficult Tracheal Intubation in Obese Gastric Bypass patients.

    abstract:BACKGROUND:Endotracheal intubation is commonly perceived to be more difficult in obese patients than in lean patients. Primarily, we investigated the association between difficult tracheal intubation (DTI) and obesity, and secondarily, the association between DTI and validated scoring systems used to assess the airways...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Dohrn N,Sommer T,Bisgaard J,Rønholm E,Larsen JF

    更新日期:2016-11-01 00:00:00

  • Establishing a Reproducible Murine Animal Model of Single Anastomosis Duodenoileal Bypass with Sleeve Gastrectomy (SADl-S).

    abstract::Single-anastomosis duodenoileal bypass with sleeve gastrectomy (SADI-S) is a simplified biliopancreatic diversion. The objective of this study was to develop a reproducible animal model for SADI-S. We used three techniques for duodenal exclusion and duodenoileal anastomosis: (a) surgical clip and side-to-side anastomo...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Laura M,Mylene L,Christophe B,Boris H,Christophe M,Konstantinos A

    更新日期:2018-07-01 00:00:00

  • Baseline Pro-inflammatory Diet Is Inversely Associated with Change in Weight and Body Fat 6 Months Following-up to Bariatric Surgery.

    abstract:OBJECTIVE:To evaluate whether the baseline Dietary Inflammatory Index (DII®) was associated with weight loss and body composition change after bariatric surgery. METHODOLOGY:This longitudinal study included 132 women with obesity (BMI ≥ 35 kg/m2, 43.0 ± 9.7 years), followed up for 6 months after bariatric surgery. The...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Andrade PA,Hermsdorff HHM,Leite JIA,Shivappa N,Hébert JR,Henriques HKF,de Oliveira Barbosa Rosa C

    更新日期:2019-02-01 00:00:00

  • Which Factors Correlate with Marginal Ulcer After Surgery for Obesity?

    abstract:INTRODUCTION:Marginal ulcer is one of the most common complications after Roux-en-Y gastric bypass and is defined as an ulceration of any depth at or near the gastrojejunal anastomosis. Different risk factors have been advocated to be the causative agent. MATERIALS AND METHODS:The weighted discharges from the Nationwi...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Rodrigo DC,Jill S,Daniel M,Kimberly C,Maher EC

    更新日期:2020-12-01 00:00:00

  • Effects of omega-loop gastric bypass on vitamin D and bone metabolism in morbidly obese bariatric patients.

    abstract:BACKGROUND:Bariatric patients often suffer from nutrient deficiencies. Little is known about vitamin D levels and bone metabolism in patients undergoing omega-loop gastric bypass (OLGB). We, therefore, evaluated parameters of vitamin D metabolism preoperatively and during the first postoperative year. METHODS:Within o...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Luger M,Kruschitz R,Langer F,Prager G,Walker M,Marculescu R,Hoppichler F,Schindler K,Ludvik B

    更新日期:2015-06-01 00:00:00

  • Conversional surgery: single-step conversion of laparoscopic adjustable gastric band to laparoscopic sleeve gastrectomy.

    abstract:BACKGROUND:Although some patients attain good outcomes after adjustable gastric band (LAGB), a certain quantity have experienced complications and insufficient weight loss. The objective of this study is to assess the safety and outcome of laparoscopic sleeve gastrectomy (LSG) as a conversion surgery after a failed LAG...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Al Sharqawi N,Al Sabah S,Al Mulla A,Al Anezi K,Jumaa T

    更新日期:2014-10-01 00:00:00

  • Obese Adolescents Report Better Health-Related Quality of Life than Obese Young Adults.

    abstract:BACKGROUND:Impairment in health-related quality of life (HRQOL) is described as a major concern for severely obese adolescents seeking intentional weight loss. We aimed to compare HRQOL in obese adolescents seeking weight loss with body mass index (BMI)-matched younger adults and community norms. METHODS:Eighty-one ad...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Dixon JB,Rice TL,Lambert EA,Lambert GW

    更新日期:2015-11-01 00:00:00

  • Upper Gastrointestinal Endoscopy prior to Bariatric Surgery-Mandatory or Expendable? An Analysis of 801 Cases.

    abstract:BACKGROUND:Upper gastrointestinal pathologies are common in bariatric patients. Preoperative esophagogastroduodenal endoscopy (EGD) should detect and treat pathologies that might alter the type of bariatric surgery. However, clinical consequences of these findings are often insignificant. The aim of this study was to a...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Wolter S,Duprée A,Miro J,Schroeder C,Jansen MI,Schulze-Zur-Wiesch C,Groth S,Izbicki J,Mann O,Busch P

    更新日期:2017-08-01 00:00:00

  • Oral Health Implications of Bariatric Surgery in Morbidly Obese Patients: An Integrative Review.

    abstract:BACKGROUND:To identify the implications of bariatric surgery on the oral health of patients with morbid obesity. METHODS:Two reviewers independently performed a search of the electronic databases: MedLine, PubMed, SciELO, LILACS, and Scopus, for clinical trials in humans and cohort studies. The search strategy used wa...

    journal_title:Obesity surgery

    pub_type: 杂志文章,评审


    authors: da Silva Azevedo ML,Silva NR,da Costa Cunha Mafra CA,Lins RDAU,Dantas EM,de Vasconcelos Gurgel BC,de Aquino Martins ARL

    更新日期:2020-04-01 00:00:00

  • Internal hernia as a complication of laparoscopic Roux-en-Y gastric bypass.

    abstract:BACKGROUND:Internal hernia (IH) is a well known complication of Roux-en-Y gastric bypass (RYGBP) which is more frequently encountered when the RYGBP is done laparoscopically. METHODS:Patients with IH were identified from a prospective data-base of morbidly obese patients undergoing bariatric surgery at our center. RE...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Iannelli A,Buratti MS,Novellas S,Dahman M,Amor IB,Sejor E,Facchiano E,Addeo P,Gugenheim J

    更新日期:2007-10-01 00:00:00

  • Impact of Bariatric Surgery on Heme Oxygenase-1, Inflammation, and Insulin Resistance in Morbid Obesity with Obstructive Sleep Apnea.

    abstract:INTRODUCTION:Morbid obesity and obstructive sleep apnea (OSA) interact at an inflammatory level. Bariatric surgery reduces inflammatory responses associated with obesity. Heme oxygenase-1 (HO-1) is an enzyme with anti-inflammatory properties, which might be increased in morbid obesity or OSA. We studied morbidly obese ...

    journal_title:Obesity surgery

    pub_type: 临床试验,杂志文章


    authors: Tirado R,Masdeu MJ,Vigil L,Rigla M,Luna A,Rebasa P,Pareja R,Hurtado M,Caixàs A

    更新日期:2017-09-01 00:00:00

  • A Comparison of the Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Body Mass Composition as Measured by Air Displacement Plethysmography.

    abstract:BACKGROUND:The laparoscopic sleeve gastrectomy (LSG) is now the most commonly performed bariatric surgery in the world. Multiple studies have demonstrated the equivalence between the LSG and Roux-en-Y gastric bypass (RYGB) with regard to weight loss and comorbidity resolution. Few studies have examined the differences ...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Kavanagh R,Smith J,Avgenackis E,Jones D,Nau P

    更新日期:2020-02-01 00:00:00

  • Histological findings in the liver before and after gastric bypass.

    abstract:BACKGROUND:Bariatric surgery results in massive loss of excess weight, changes in co-morbidities and improvement in quality of life. In these patients, liver histology taken before or during surgery reveals several histological abnormalities. In a prospective study of patients previously submitted to gastric bypass, we...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Csendes A,Smok G,Burgos AM

    更新日期:2006-05-01 00:00:00

  • Perforator-sparing abdominoplasty technique in the presence of bilateral subcostal scars after gastric bypass.

    abstract:BACKGROUND:The number of patients after gastric bypass being referred to plastic surgery units for secondary plastic surgery procedures is increasing. The characteristic abdominal deformity includes a draping apron of panniculus, occasionally associated with previous transverse surgical scars in the upper abdomen. Ofte...

    journal_title:Obesity surgery

    pub_type: 杂志文章


    authors: Rieger UM,Aschwanden M,Schmid D,Kalbermatten DF,Pierer G,Haug M

    更新日期:2007-01-01 00:00:00