The Stromal Vascular Fraction Improves Maintenance of the Fat Graft Volume: A Systematic Review.

Abstract:

BACKGROUND AND OBJECTIVES:With the continued application of fat grafting in plastic surgery, many studies have focused on various factors to improve maintenance of the fat graft volume, such as platelet-rich plasma, adipose-derived stromal/stem cells, and the stromal vascular fraction (SVF). In addition, many review articles have investigated the functions of platelet-rich plasma and adipose-derived stromal/stem cells in fat grafting, although the usefulness of the SVF remains unclear. The aim of the present review was to determine whether SVF use could maintain a fat graft. METHODS:A systematic review was conducted of the PubMed, Cochrane Central Register of Controlled Trials, and Embase databases of original articles published up to February 2018. RESULTS:Relevant articles were identified by screening the abstracts. A total of 58 full texts were initially identified. After exclusion, 17 articles, including 6 animal studies and 11 clinical studies, were included for analysis. CONCLUSIONS:Most studies found a significant and measurable long-term effect of SVF-enhanced fat grafting on breast augmentation and defects, wound healing, scaring, and facial aesthetic outcomes. Stromal vascular fraction use did not result in a higher instance of complications and, thus, can be considered a safe option for fat grafting.

journal_name

Ann Plast Surg

authors

Cai W,Yu LD,Tang X,Shen G

doi

10.1097/SAP.0000000000001589

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

367-371

issue

3

eissn

0148-7043

issn

1536-3708

pii

00000637-201809000-00024

journal_volume

81

pub_type

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