Abstract:
:The highly polymorphic locus D2S3 is revealed by three single-copy probes from cosmid C1-5. These probes, 1-30, 1-32, and 2-96, collectively reveal seven restriction fragment length polymorphisms. Fifty-three of 56 unrelated individuals (93%) were heterozygous at one or more of the seven loci, making the compound locus a very useful marker for gene mapping. Chromosomal assignment of D2S3 was obtained using a panel of human X hamster and human X mouse somatic cell hybrids. Molecular hybridization of EcoRI-digested DNA from these cell lines with the DNA inserts from subclones 1-30, 1-32, and 2-96 showed that all three probes mapped to the long arm of chromosome 2. Additionally, in situ hybridization of [3H]-labeled probe 2-96 to metaphase chromosome preparations allowed more precise assignment of the locus to the region 2q35----37.
journal_name
Am J Hum Genetjournal_title
American journal of human geneticsauthors
Litt M,Bruns GA,Sheehy R,Magenis REsubject
Has Abstractpub_date
1986-03-01 00:00:00pages
288-96issue
3eissn
0002-9297issn
1537-6605journal_volume
38pub_type
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journal_title:American journal of human genetics
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journal_title:American journal of human genetics
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journal_title:American journal of human genetics
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journal_title:American journal of human genetics
pub_type: 杂志文章
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更新日期:1996-08-01 00:00:00
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journal_title:American journal of human genetics
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pub_type: 杂志文章,多中心研究
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journal_title:American journal of human genetics
pub_type: 杂志文章
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更新日期:1982-03-01 00:00:00
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journal_title:American journal of human genetics
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journal_title:American journal of human genetics
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