Abstract:
BACKGROUND:Methadone is an attractive medication for treating children with advanced cancer with pain as it is the only long-acting opioid available as a liquid. However, it is not frequently used due to concerns about potential toxicities and side effects. OBJECTIVE:Evaluate the efficacy and safety of methadone as the first long-acting opioid in children with advanced cancer. DESIGN:Retrospective chart review of 52 consecutive patients referred to Pediatric Supportive Care for pain management started on methadone as their first long-acting opioid. Data collected at baseline, follow-up visits #1 (F1) and #2 (F2) included child and parent-reported outcomes for various physical and psychological symptoms, opioid side effects and other clinical data. Symptoms were rated on a 0 (not at all) to 4 (a lot) scale. RESULTS:Pain (mean ± standard deviation [SD]) scored by the child was 3.6 (±0.6)/4 at baseline and 1.8 (±1.1)/4 at F1 (p < 0.0001). Compared to baseline, pain scored by the child at F2 was 1.2 (±1.3)/4 (p < 0.0001). Pain scored by the parent was 3.5 (±0.7)/4 at baseline and 1.4 (±1.3)/4 at F1 (p < 0.0001). Compared to baseline, pain scored by the parent at F2 was 1.0 (±1.2)/4 (p < 0.0001). Thirty-three (70%) patients at F1 and 23 (79%) patients at F2 did not need a change in dose of methadone. No cardiac arrhythmias or opioid neurotoxicity was observed. CONCLUSIONS:Initiation of methadone was effective and safe as the first long-acting opioid in children with pain.
journal_name
J Palliat Medjournal_title
Journal of palliative medicineauthors
Madden K,Mills S,Dibaj S,Williams JL,Liu D,Bruera Edoi
10.1089/jpm.2017.0712subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1317-1321issue
9eissn
1096-6218issn
1557-7740journal_volume
21pub_type
杂志文章abstract:BACKGROUND:Improving access to palliative care is an important priority for hospitals as they strive to provide the best care and quality of life for their patients. Even in hospitals with longstanding palliative care programs, only a small proportion of patients with life-threatening illnesses receive palliative care ...
journal_title:Journal of palliative medicine
pub_type: 杂志文章,多中心研究
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abstract:BACKGROUND/AIM:Palliative care services (PCS) are recommended to enhance quality of care for hospitalized patients. METHODS:We evaluated the attitudes of liver transplant (LT) providers and perceived barriers to PCS for their patients by conducting a web-based survey of intensive care unit nurses, postgraduate year 1 ...
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pub_type: 杂志文章,评审
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journal_title:Journal of palliative medicine
pub_type: 杂志文章,评审
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doi:10.1089/jpm.2009.0178
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journal_title:Journal of palliative medicine
pub_type: 杂志文章
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更新日期:2020-09-03 00:00:00
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pub_type: 杂志文章,随机对照试验
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