Abstract：
PURPOSE:To assess changes in the patterns of T2 and T1rho values within grade 1 cartilage lesions of osteoarthritis (OA) patients compared to healthy controls. MATERIALS AND METHODS:Twenty healthy knees and 25 OA knees were examined on a 3 T scanner. Areas of signal heterogeneity within the cartilage of the distal femur were identified using fat suppressed proton density-weighted imagines. T2 and T1rho values in each OA patient with grade 1 lesions were compared to average T2 and T1rho values of the corresponding areas in healthy subjects. RESULTS:A total of 28 areas including grade 1 lesion were identified. Compared to normal cartilage, the majority of grade 1 cartilage lesions demonstrated either no significant change or a statistically significant increase in both T2 values (18/28, 64%) and T1rho values (23/28, 82%). Compared to T2, T1rho demonstrated a greater proportion of statistically significantly higher values in OA patients than those from the normal controls. However, T2 and T1rho values in grade 1 lesions can be decreased, or demonstrate mixed patterns compared to those in healthy cartilage. CONCLUSION:Our results suggest that early degenerative cartilage lesions can demonstrate various patterns of T2 and T1rho changes.
journal_name
Clin Imagingjournal_title
Clinical imagingauthors
Kaneko Y,Nozaki T,Yu H,Schwarzkopf R,Hara T,Yoshioka Hdoi
10.1016/j.clinimag.2018.03.017subject
Has Abstractpub_date
2018-01-01 00:00:00pages
201-207eissn
0899-7071issn
1873-4499pii
S0899-7071(18)30066-4journal_volume
50pub_type
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