Encephalopathy from unintentional donepezil and memantine ingestion.

Abstract:

:Donepezil and memantine are commonly prescribed antidementia drugs. There is a paucity of literature concerning pediatric ingestions of these drugs. We describe a case of a 2-year-old child who developed encephalopathy after an unintentional ingestion of donepezil and memantine. A 2-year-old girl was found by her family members agitated and reporting visual hallucinations. In the emergency department, she became sedated and had rightward eye deviation. She was hospitalized and had extensive neurological and infectious disease testing that was unremarkable, except for an electroencephalogram, which showed a nonspecific encephalopathy. She recovered with supportive care for 72 hours. Serum concentrations of donepezil and memantine measured on arrival were 470 ng/mL (therapeutic range, 25-50 ng/mL) and 32 ng/mL (therapeutic range, 70-150 ng/mL), respectively. This case demonstrates that unintentional ingestions of memantine and donepezil can potentially cause significant and prolonged neurological symptoms in pediatric patients.

journal_name

Pediatr Emerg Care

journal_title

Pediatric emergency care

authors

Thornton SL,Clark RF

doi

10.1097/PEC.0000000000000216

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

649-50

issue

9

eissn

0749-5161

issn

1535-1815

pii

00006565-201409000-00014

journal_volume

30

pub_type

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