Abstract:
OBJECTIVE:To establish a feasible rat model of radiation-induced erectile dysfunction after targeted prostate irradiation using an image-guided irradiation unit specially designed for small-animal radiation research. METHODS:The X-RAD 225Cx research platform was used in the present study. We first performed quality assurance testing using a rat cadaver. After confirming dosimetry, 24 age-matched, young, adult, male rats were assigned to sham radiation or radiation to the prostate with doses of 15, 20, or 25 Gy. To confirm appropriate prostate irradiation, physiological erectile function was evaluated using intracavernous pressure (ICP) measurements with cavernous nerve electrical stimulation at 9 weeks after radiotherapy. Each animal was weighed at the time of ICP measurement. In addition, we investigated the cyclic guanosine monophosphate level in the penile cavernosa using a commercial enzyme-linked immunosorbent assay kit. RESULTS:Quality assurance results confirmed the accuracy of the irradiation technique. Dose-dependent decreases in ICP in irradiated rats were observed without major toxicity. No difference in body weight was noted among the experimental groups. Cyclic guanosine monophosphate levels were significantly decreased in the group that received 25 Gy compared with the age-matched sham-irradiated group. CONCLUSION:High-precision imaging and targeting capabilities provided by the micro-IGRT platform enable us to develop a reproducible animal model of radiation-induced erectile dysfunction in prostate cancer research.
journal_name
Urologyjournal_title
Urologyauthors
Kimura M,Zodda AR,Mahmood J,Das SK,Nguyen GB,Jackson IL,Vujaskovic Zdoi
10.1016/j.urology.2014.12.020subject
Has Abstractpub_date
2015-05-01 00:00:00pages
1214.e1-1214.e6issue
5eissn
0090-4295issn
1527-9995pii
S0090-4295(14)01396-Xjournal_volume
85pub_type
杂志文章相关文献
UROLOGY文献大全abstract:OBJECTIVES:We studied 485 patients treated by extracorporeal shock-wave lithotripsy (ESWL) using an ultrasound electrohydraulic apparatus in an effort to define radiographic criteria for better patient selection for ESWL. METHODS:Results were assessed according to plain x-ray nephrotomography and ultrasound. The crite...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(96)00251-8
更新日期:1996-10-01 00:00:00
abstract:OBJECTIVES:To evaluate catalase- and superoxide dismutase (SOD)-like activities in the seminal plasma of fertile and infertile men. METHODS:Semen samples were obtained from consecutive men presenting for vasectomy (n = 12) and infertility evaluation (n = 105) at our institution. Catalase-like activity was measured by ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(00)00453-2
更新日期:2000-06-01 00:00:00
abstract::Seventeen children who had vesicoureteral reflux underwent urodynamic and rectal manometric studies. All had uninhibited bladder contractions. All had rectal dilatation confirming the presence of constipation by rectal balloon manometry. The recurrent association of constipation with ureteral reflux suggests the possi...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(86)90070-1
更新日期:1986-11-01 00:00:00
abstract::A case is presented for the routine determination of detrusor pressure in the performance of urodynamic studies. Its particular value in the investigation of the patient with subtle bladder instability, urinary incontinence, and voiding dysfunction is described. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(80)90583-x
更新日期:1980-12-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of 24-hour urine collection among first-time pediatric stone formers and investigate factors associated with its use. MATERIALS AND METHODS:Using data from the MarketScan Commercial Claims and Encounters Database (2002-2006), children presenting to the emergency department with an...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2014.04.035
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:To perform immune-cell enumeration and programmed death-ligand 1 (PD-L1) expression in clear cell renal cell carcinoma (cc-RCC) with tumor thrombus (TT) to guide therapeutic decisions. METHODS:After obtaining IRB approval and surgical consent, 6 patients underwent radical nephrectomy with venous tumor thromb...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2018.09.018
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVES:To verify whether alterations in bone density and turnover in patients with calcium nephrolithiasis and hypercalciuria are observable in various subgroups of patients divided according to the pathogenesis of the hypercalciuria. METHODS:Seventy patients with calcium nephrolithiasis and idiopathic hypercalciu...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(02)01626-6
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVES:To develop a method for assessing absolute renal function (as well as morphology) in children, using gamma camera imaging of intravenously injected technetium-99m (99mTc) dimercaptosuccinic acid (DMSA). METHODS:Forty-five children (ages 1 week to 10 years; mean, 2.0 years) were imaged using a planar techniq...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/s0090-4295(99)80461-0
更新日期:1996-03-01 00:00:00
abstract:OBJECTIVE:To study the feasibility and safety of laparoscopic radical cystectomy with intracorporeal orthotopic ileal neobladder and to evaluate the role of endoscopic stapling in neobladder construction. MATERIALS AND METHODS:Fifty-five patients with bladder cancer who underwent laparoscopic radical cystectomy were r...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2014.09.059
更新日期:2015-02-01 00:00:00
abstract::A literature review of PubMed reveals that 1 case report is found of a retained Foley catheter for 3 years. We report a case of a straight catheter lost in the urethra and forgotten for 20 years and its safe surgical removal. The calcified straight catheter was removed through a perineal urethrostomy and incision at t...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2010.01.063
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To identify risk factors for recurrent urinary tract infection (UTI) in patients who perform clean intermittent catheterization (CIC). METHODS:A 6-year retrospective chart review of patients with spina bifida or tethered cord who perform clean intermittent catheterization (8 months to 58 years) was conducted...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2016.12.049
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVES:To assess the prevalence and pathologic features of men with unilateral prostate cancer at radical prostatectomy (RP), because it has recently been proposed that men with small-volume, well-differentiated, unilateral prostate cancer can be treated with focal therapy. METHODS:The records of 1467 consecutive ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2008.08.504
更新日期:2009-02-01 00:00:00
abstract::In this study, the cytologic diagnosis obtained by transrectal fine needle prostatic aspiration was compared to the histologic diagnosis obtained by prostatic needle biopsy or transurethral prostatic resection. Confirmation of all diagnoses occurred 91 per cent of the time: 96 per cent with benign prostatic hyperplasi...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(82)90044-9
更新日期:1982-01-01 00:00:00
abstract:OBJECTIVE:To assess the morbidity, mortality, and impact on quality of life and renal function after laparoscopic cystectomy and ileal conduit in patients with multiple sclerosis with lower urinary tract symptom refractory to conservative management. MATERIALS AND METHODS:A prospective study was conducted between Febr...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/j.urology.2012.06.039
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To demonstrate the substantial litigious risks associated with vasectomy, a common urologic procedure. We examined the risk factors and types of negligence involved in vasectomy cases that go to trial and their associated outcomes. METHODS:Using the Westlaw legal database, we searched all jury verdicts and s...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2019.05.035
更新日期:2019-09-01 00:00:00
abstract::Alveolar rhabdomyosarcoma is an aggressive cancer that can metastasize to a variety of organs. We present what we believe to be the first reported case of metastatic intratesticular rhabdomyosarcoma in a patient presenting with testicular pain shortly after the induction of systemic chemotherapy. The published data re...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.02.023
更新日期:2007-05-01 00:00:00
abstract::Immunoglobulin A (IgA) levels in semen and in prostatic fluid of 48 patients with benign and malignant diseases of the prostate were estimated. It is speculated from this small study that the IgA levels rise in benign prostatic hyperplasia; in early adenocarcinoma of the prostate (Stages A and B) the rise if furthered...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(76)90384-8
更新日期:1976-09-01 00:00:00
abstract:OBJECTIVES:To assess the influence of intravesical instillation of epirubicin or bacille Calmette-Guérin (BCG) in patients with bladder cancer on the clinical performance of the uCyt+ test, which traces the three monoclonal antibodies M344, LDQ 10, and 19A211 in urothelial cells. METHODS:A total of 267 patients with a...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2003.12.023
更新日期:2004-05-01 00:00:00
abstract::As a result of variations in disease definition and diagnostic criteria for interstitial cystitis (IC), the performance of epidemiologic studies has been challenging. Initial prevalence studies used physician-confirmed diagnoses of IC; more recent studies, which have incorporated the use of patient responses to valida...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2006.05.050
更新日期:2007-04-01 00:00:00
abstract::The relationship of prior hormonal therapy to subsequent response on estramustine phosphate (Estracyt) was examined in 107 patients with advanced prostatic cancer treated in two different Phase II chemotherapy trials. In both trials patients with the longest prior hormonal treatment were the least likely to respond to...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/0090-4295(79)90521-1
更新日期:1979-12-01 00:00:00
abstract::A simple technique for intracorporeal knot tying is discussed. Laparoscopic applications in urology initially began as simple diagnostic procedures to examine impalpable undescended testes and as an adjunct to help in management of intersex disorders. Subsequently, extirpative procedures have developed as technology h...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(94)80063-4
更新日期:1994-10-01 00:00:00
abstract::MicroRNAs (miRNA) are a class of naturally occurring, small, noncoding RNAs that function as specific repressors of protein-encoding genes, being pivotal regulators of development and cellular homeostasis. They have been functionally classified as proto-oncogenes or tumor suppressors and are aberrantly expressed in di...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/j.urology.2010.03.012
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To evaluate how different methods for storage and preservation of urine samples affected the outcome of analysis of risk factors for stone formation. METHODS:Spot urine samples were collected from 21 healthy volunteers. Each fresh urine sample was divided into ten 10-mL aliquots: 2 without preservative, 2 wi...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2014.10.030
更新日期:2015-02-01 00:00:00
abstract::Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma of childhood, while RMS from the urinary tract has rarely been reported. Aspects of the manifestation, diagnosis, and treatment of these tumors are discussed in the case of a girl with rapidly progressive RMS from the urethral tract. She was treated with a ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.03.022
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVES:The present study was designed to determine the relationship between serum prostate-specific antigen (PSA) levels and prostatic epithelial volumes. METHODS:Forty-two men between the ages of 50 and 79 years of age with either an abnormal digital rectal examination (DRE) or a serum PSA level > 4 ng/dL underwe...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(94)80131-2
更新日期:1994-08-01 00:00:00
abstract::Of 293 patients with transitional cell carcinoma of the bladder seen at our institution between April 1977 and December 1987, 9 patients were found to have brain metastasis. Seven of 9 patients were found to have a solitary brain lesion, and in 4 of these, no other site of metastatic disease was identified. Five patie...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/0090-4295(92)90034-t
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVES:Shorter CAG repeat lengths in exon 1 of the androgen receptor (AR) gene are associated with a stronger transcriptional activity of the AR and with a higher risk of prostate cancer. Because benign prostatic hyperplasia (BPH) is an androgen-dependent condition, we examined the hypothesis that men with shorter ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(98)00468-3
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To determine whether phosphatidylinositol-4,5-bisphosphate 3- kinase, catalytic subunit alpha (PIK3CA) copy number gain in penile cancer has prognostic value and association with histopathological parameters, human papillomavirus (HPV), and clinical outcome. METHODS:PIK3CA copy number status was assessed wit...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2018.03.056
更新日期:2018-07-19 00:00:00
abstract::In 1988 the KTP-532 laser was used to ablate a series of benign urethral strictures. Rather than using a single incision as in urethrotomy, strictures were treated with 360-degree contact photoradiation. Thirty-one male patients, average age 53.2 years, received thirty-seven treatments; 6 patients underwent a second l...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(92)90382-7
更新日期:1992-10-01 00:00:00
abstract:OBJECTIVE:To present a novel surgical concept using preoperative imaging to estimate length needed for ileal segment. This enables robotic ileal interposition to be completed with only 1 position change during surgery. MATERIALS AND METHODS:The index patient is a 69-year-old woman with a history of stage IIIB cervical...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2017.02.033
更新日期:2017-06-01 00:00:00