Abstract：
:Reports in recent years indicate that the increasing emergence of resistance to drugs be using to TB treatment. The resistance to them severely affects to options for effective treatment. The emergence of multidrug-resistant tuberculosis has increased interest in understanding the mechanism of drug resistance in M. tuberculosis and the development of new therapeutics, diagnostics and vaccines. In this study, a label-free quantitative proteomics approach has been used to analyze proteome of multidrug-resistant and susceptible clinical isolates of M. tuberculosis and identify differences in protein abundance between the two groups. With this approach, we were able to identify a total of 1,583 proteins. The majority of identified proteins have predicted roles in lipid metabolism, intermediary metabolism, cell wall and cell processes. Comparative analysis revealed that 68 proteins identified by at least two peptides showed significant differences of at least twofolds in relative abundance between two groups. In all protein differences, the increase of some considering proteins such as NADH dehydrogenase, probable aldehyde dehydrogenase, cyclopropane mycolic acid synthase 3, probable arabinosyltransferase A, putative lipoprotein, uncharacterized oxidoreductase and six membrane proteins in resistant isolates might be involved in the drug resistance and to be potential diagnostic protein targets. The decrease in abundance of proteins related to secretion system and immunogenicity (ESAT-6-like proteins, ESX-1 secretion system associated proteins, O-antigen export system and MPT63) in the multidrug-resistant strains can be a defensive mechanism undertaken by the resistant cell.
journal_name
Indian J Microbioljournal_title
Indian journal of microbiologyauthors
Phong TQ,Ha do TT,Volker U,Hammer Edoi
10.1007/s12088-015-0511-2subject
Has Abstractpub_date
2015-06-01 00:00:00pages
219-30issue
2eissn
0046-8991issn
0973-7715pii
511journal_volume
55pub_type
杂志文章abstract：:Photorhabdus is an insect-pathogenic Gram negative enterobacterium found in the gut of Heterorhabditis nematodes. Photorhabdus is highly virulent to insects, and can kill insects rapidly upon injection at very low concentrations of one to few cells. We characterized the virulence of Photorhabdus symbionts isolated fro...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-016-0628-y
更新日期：2017-03-01 00:00:00
abstract：:The bacterial strains resistant to pentachlorophenol (PCP) and hexavalent chromium [Cr(VI)] were isolated from treated tannery effluent of a common effluent treatment plant. Most of the physico-chemical parameters analyzed were above permissible limits. Thirty-eight and four bacterial isolates, respectively were found...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-011-0089-2
更新日期：2011-01-01 00:00:00
abstract：:Scoparia dulcis of Scrophulariaceae is an annual herb distributed through out the tropics. Penicillium citrinum was obtained from apparently healthy roots, stem, leaves and fruits of this plant. Callus and multiple shoots produced during micropropagation from various explants were also symptomless but showed occurrenc...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-010-0065-2
更新日期：2010-10-01 00:00:00
abstract：:The availability of complete genome sequences of many bacterial species is facilitating numerous computational approaches for understanding bacterial genomes. One of the major incentives behind the genome sequencing of many pathogenic bacteria is the desire to better understand their diversity and to develop new appro...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-008-0025-2
更新日期：2008-06-01 00:00:00
abstract：:Pathogenic Klebsiella pneumoniae, resistant to beta-lactam and quinolone drugs, is widely recognized as important bacteria causing array of diseases. The resistance property is obtained by acquisition of plasmid encoded blaTEM, blaSHV, blaCTX-M, QNRA, QNRB and QNRS genes. The aim of this study was to document the prev...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-012-0281-z
更新日期：2012-12-01 00:00:00
abstract：:Phoma is a highly polyphyletic genus with its unclear species boundaries. The conventional system of identification is functional but it has its limitations. Besides morphological studies, chemotaxonomy, secondary metabolite and protein profiling have been assessed for the classification and identification of these fu...
journal_title：Indian journal of microbiology
pub_type： 杂志文章,评审
doi：10.1007/s12088-013-0442-8
更新日期：2014-06-01 00:00:00
abstract：:The biodiversity of epilithic cyanobacteria from one of the unexplored habitats of freshwater streams of Kakoijana reserve forest of Assam, India was estimated. This paper lists a total of 29 species representing 18 genera of 12 families and 4 orders as per recent system of classification. Morphological descriptions, ...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-007-0043-5
更新日期：2007-09-01 00:00:00
abstract：:Plants possess a range of active defense apparatuses that can be actively expressed in response to biotic stresses (pathogens and parasites) of various scales (ranging from microscopic viruses to phytophagous insect). The timing of this defense response is critical and reflects on the difference between coping and suc...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-007-0054-2
更新日期：2007-12-01 00:00:00
abstract：:Start of the 21st century with its universal call to feed the hungry is an appropriate time to refocus attention on food security and especially the impact of biopatenting on poor communities who are the primary victims of hunger in our world. Antibacterial metabolites of lactic acid bacteria and Bacillus spp have pot...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-009-0048-3
更新日期：2009-09-01 00:00:00
abstract：:Bio-softening of the mature coconut husk using Basidiomyceteous fungi was attempted to recover the soft and whiter fibers. The process was faster and more efficient in degrading lignin and toxic phenolics. Phanerochaete chrysosporium, Pleurotus eryngii and Ceriporiopsis subvermispora were found to degrade lignin effic...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-007-0031-9
更新日期：2007-06-01 00:00:00
abstract：:As the SARS-CoV-2 virus race around the world across the different population, there needs to be a consolidated effort to understand the divergence of demographically distributed strains. The emerging trends in SARS-CoV-2 genome data show specific mutation and genetic diversity, which could provide the basis to develo...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-020-00869-4
更新日期：2020-04-20 00:00:00
abstract：:In sectors like healthcare and hospitality, it has been realized that fabrics play a pivotal role in transfer of nosocomial infections. However, there is a major gap in drawing correlation between different fibre types and their interaction with microorganisms. Such information is important to formulate guidelines for...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-020-00903-5
更新日期：2021-03-01 00:00:00
abstract：:An endophytic species of Micrococcus was isolated from Aloe vera leaf (syn. Aloe barbadensis) and screened for protease production with five other species of Micrococcus. Data indicated that endophytic Micrococcus aloeverae AE-6 MCC 2184T and Micrococcus yunnanensis DSM 21948T showed efficient protease production pote...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-017-0638-4
更新日期：2017-06-01 00:00:00
abstract：:In this study, Aeromonas salmonicida subsp. salmonicida was isolated, identified by 16S RNA sequencing and its potential lytic phage (ASP-1) was isolated and characterized. The bacterium was positive for virulence genes (ascV, fla, ahyB, gcaT, lip, alt and act) and phenotypic parameters (haemolysis, slime production, ...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-019-00782-5
更新日期：2019-06-01 00:00:00
abstract：:A marked reduction in uptake of α-santonin, accompanied by loss of ability of cells to transform the substrate, is observed on shocking Sphingomonas paucimobilis strain S ATCC 43388 cells by freeze - thaw method. The shock fluid shows a 26% quench in fluorescence at 350nm on incubation with the substrate. Addition of ...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-007-0064-0
更新日期：2007-12-01 00:00:00
abstract：:The present study was conducted to develop and evaluate an experimental ISCOM-based infectious bursal disease (IBD) vaccine. The indigenous very virulent infectious bursal disease virus (vvIBDV) already attenuated and adapted to Vero cell line was used. After denaturation of viral proteins with sodium dodecyl sulphate...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-008-0048-8
更新日期：2008-09-01 00:00:00
abstract：:Thermophilic bacteria are actively prevalent in hot water springs. Their potential to grow and sustain at higher temperatures makes them exceptional compare to other microorganism. The present study was initiated to isolate, identify and determine the feasibility of extraction of copper using thermophilic heterotrophi...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-011-0073-x
更新日期：2011-10-01 00:00:00
abstract：:Marine bacteria possess a wide variety of bioremediation potential which is beneficial environmentally and economically. In this study, bacterial isolates from marine waters were screened for tolerance and growth in high concentrations of chromate (Cr6+). Two isolates, capable of tolerating Cr6+ concentrations 300 µg ...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-017-0668-y
更新日期：2017-12-01 00:00:00
abstract：:This report described the efficacy of NA inhibitors against newly evolved strains of H1N1 viruses. This in silico study was designed to understand the mode of interactions of NA inhibitors with NA. Hence, ligand, oseltamivir, zanamivir and peramivir were docked with modeled NA, ACD65204 (USA/2007), BAA06717 (Japan/199...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-009-0065-2
更新日期：2009-12-01 00:00:00
abstract：:This study reports the identification of ionising radiation tolerant bacteria from a high elevation arid region of central Tibet. Nineteen isolates were isolated from soil exposed to ionising radiation at doses from 0 to 15 kGy. Isolates were phylogenetically characterised using 16S rRNA gene sequences. Most isolates ...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-016-0604-6
更新日期：2016-12-01 00:00:00
abstract：:Sulfate-reducing bacteria (SRB) were found to be capable of tolerating a certain amount of oxygen (O2), but how they affect oxygen reduction reaction (ORR) has not been clear. The present work investigated the impact of SRB on ORR in 3.5 wt% sodium chloride solution with the cyclic voltammetry method. The addition of ...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-017-0667-z
更新日期：2017-09-01 00:00:00
abstract：:This paper demonstrated a biocementation technology for chromium slag by strain GM-1, a calcifying ureolytic bacterium identified as Microbacterium, based on microbially induced calcium carbonate. The characterization of Microbacterium sp. GM-1 was assessed to know the growth curve in different concentrations of Cr(VI...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-016-0579-3
更新日期：2016-09-01 00:00:00
abstract：:Bacteria possessing multiple copies of 16S rRNA (rrs) gene demonstrate high intragenomic heterogeneity. It hinders clear distinction at species level and even leads to overestimation of the bacterial diversity. Fifty completely sequenced genomes belonging to 19 species of Lactobacillus species were found to possess 4-...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-016-0605-5
更新日期：2016-09-01 00:00:00
abstract：:Staphylococcus warneri, isolated from the cervix of an adult female with unexplained infertility, was found to agglutinate human spermatozoa in vitro leading to their death. A genomic library of S. warneri was generated using pSMART-Escherichia coli vector-host system. Approximately 3500 transformants were screened an...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-018-0766-5
更新日期：2019-03-01 00:00:00
abstract：:The native population of phosphate solubilizing bacteria (PSB) was studied in the rhizosphere of chickpea, mustard and wheat grown in different regions of Haryana. A total of 193 PSB were isolated from 245 rhizospheric samples collected from south-west and north-east zones. The PSB count showed large variations (3-67 ...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-009-0016-y
更新日期：2009-06-01 00:00:00
abstract：:Carbon cycling in the hypersaline microbial mats from Chiprana Lake, Spain is primarily dependent on phototrophic microorganisms with the ability to fix CO2 into organics that can be further utilized by aerobic as well as anaerobic heterotrophic bacteria. Here, mat pieces were incubated in seawater amended with (14)C ...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-011-0239-6
更新日期：2012-03-01 00:00:00
abstract：:Terminalia chebula Retz. is a northern Indian plant species known for its anti-inflammatory and antimicrobial properties. T. chebula fruit powder was extracted with solvents of varying polarity and screened for bacterial growth inhibition by disc diffusion assay. The minimum inhibitory concentration (MIC) was quantifi...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-018-0754-9
更新日期：2018-12-01 00:00:00
abstract：:Culture-independent approaches to analyze metagenome are practical choices for rapid exploring useful genes. The mg-MSDH gene, acquired from the hot spring metagenomic, was retrieved full lengths of functional gene using semi-nest touch-down PCR. Two pairs of degenerate primers were used to separate seven conserve par...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-013-0405-0
更新日期：2014-03-01 00:00:00
abstract：:Rhizobacteria belonging to Bacillus sp. were isolated from the rhizosphere of chickpea (Cicer arietinum). Ten Bacillus strains were studied for their antifungal activity, effect on seedling emergence and plant growth promotion. Two Bacillus strains CBS127 and CBS155 inhibited the growth of all the four pathogenic fung...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-007-0010-1
更新日期：2007-03-01 00:00:00
abstract：:The use of organometallic compounds in the environment is constantly increasing with increased technology and progress in scientific research. But since these compounds are fairly stable, as metallic bonds are stable, they are difficult to degrade or decompose naturally. The aim of this work was to isolate and charact...
journal_title：Indian journal of microbiology
pub_type： 杂志文章
doi：10.1007/s12088-011-0223-1
更新日期：2012-06-01 00:00:00
