Abstract:
:There has been substantial progress in psychiatric genetics in recent years, through collaborative efforts to build large samples sizes for case/control analyses for a number of psychiatric disorders. The identification of replicated trait-associated genomic loci represents a large stride forward in a field where little is known about the biological processes involved in disorder. As researchers build on this early foundation, they are beginning to advance the field towards more fine-grained approaches that interrogate the many sources of heterogeneity within psychiatric genetics that can obscure the identification of genotypic influences on disorder. In this review, we provide a brief overview, across a range of psychiatric diagnoses, of recent approaches that have been employed to dissect heterogeneity to give a flavour of the current direction of the field. We group these into three main categories; tackling the heterogeneity in phenotype that is found within the diagnostic categories used within psychiatry, the many different forms of genetic variation that might influence psychiatric traits and then finally, the heterogeneity that is seen across individuals of different ancestries.
journal_name
Hum Mol Genetjournal_title
Human molecular geneticsauthors
Hodgson K,McGuffin P,Lewis CMdoi
10.1093/hmg/ddx241subject
Has Abstractpub_date
2017-10-01 00:00:00pages
R160-R165issue
R2eissn
0964-6906issn
1460-2083pii
3930111journal_volume
26pub_type
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journal_title:Human molecular genetics
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abstract::Anti-Müllerian hormone (AMH) is an essential messenger of sexual differentiation in the foetus and is an emerging biomarker of postnatal reproductive function in females. Due to a paucity of adequately sized studies, the genetic determinants of circulating AMH levels are poorly characterized. In samples from 2815 adol...
journal_title:Human molecular genetics
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journal_title:Human molecular genetics
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journal_title:Human molecular genetics
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journal_title:Human molecular genetics
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journal_title:Human molecular genetics
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journal_title:Human molecular genetics
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journal_title:Human molecular genetics
pub_type: 杂志文章
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更新日期:2019-10-15 00:00:00
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journal_title:Human molecular genetics
pub_type: 杂志文章,评审
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更新日期:2010-10-15 00:00:00
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journal_title:Human molecular genetics
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journal_title:Human molecular genetics
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abstract::A genetic contribution to the development of age-related macular degeneration (AMD) is well established. Several genome-wide linkage studies have identified a number of putative susceptibility loci for AMD but only a few of these regions have been replicated in independent studies. Here, we perform a meta-analysis of ...
journal_title:Human molecular genetics
pub_type: 杂志文章,meta分析
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更新日期:2005-08-01 00:00:00
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journal_title:Human molecular genetics
pub_type: 杂志文章
doi:10.1093/hmg/8.12.2293
更新日期:1999-11-01 00:00:00
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journal_title:Human molecular genetics
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doi:10.1093/hmg/ddp591
更新日期:2010-04-01 00:00:00
abstract::In human type 1 diabetes (T1D) and in its murine model, the major histocompatibility complex (MHC) class II molecules, human leukocyte antigens (HLA)-DQ and -DR and their murine orthologues, IA and IE, are the major genetic determinants. In this report, we have ranked HLA class II molecule-associated T1D risk in a two...
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journal_title:Human molecular genetics
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journal_title:Human molecular genetics
pub_type: 杂志文章
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journal_title:Human molecular genetics
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journal_title:Human molecular genetics
pub_type: 杂志文章
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