Abstract：
:Parkinson's disease (PD) is a neurodegenerative movement disorder. Although there is no cure, symptomatic treatments are available and can significantly improve quality of life. The motor, or movement, features of PD are caused by reduced production of the neurotransmitter dopamine. Dopamine deficiency is most often treated using dopamine replacement therapy. However, this therapy can itself lead to further motor abnormalities referred to as dyskinesia. Dyskinesia consists of involuntary jerking movements and muscle spasms, which can often be violent. To minimise dyskinesia, it is necessary to accurately titrate the amount of medication given and monitor a patient's movements. In this paper, we describe a new home monitoring device that allows dyskinesia to be measured as a patient goes about their daily activities, providing information that can assist clinicians when making changes to medication regimens. The device uses a predictive model of dyskinesia that was trained by an evolutionary algorithm, and achieves AUC>0.9 when discriminating clinically significant dyskinesia.
journal_name
J Med Systjournal_title
Journal of medical systemsauthors
Lones MA,Alty JE,Cosgrove J,Duggan-Carter P,Jamieson S,Naylor RF,Turner AJ,Smith SLdoi
10.1007/s10916-017-0811-7subject
Has Abstractpub_date
2017-09-25 00:00:00pages
176issue
11eissn
0148-5598issn
1573-689Xpii
10.1007/s10916-017-0811-7journal_volume
41pub_type
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