Abstract:
PURPOSE:Our objective was to investigate the factors predicting the survival of patients on the waiting list for lung transplantation (LT) during the waiting period, with a special emphasis on the physical activity level. METHODS:The study included 70 patients with end-stage pulmonary disease who were on the waiting list for LT at Kyoto University Hospital. We examined the association between the baseline characteristics, including the body mass index and body composition, serum albumin, serum C-reactive protein (CRP), steroid administration, physical activity level (calculated by the food frequency questionnaire) and survival during the waiting period using Kaplan-Meier curves and Cox proportional hazard regression models. RESULTS:A physical activity level of ≤1.2 was correlated with significantly decreased survival (1-year survival: 68 vs. 90.9%, p = 0.0089), with a hazard ratio (HR) of 2.24 (95% confidence interval (CI) 1.22-4.19, p = 0.0001). Hypo-albumin (HR 2.024, 95% CI 1.339-6.009, p = 0.004), a high level of CRP (HR 2.551, CI 1.229-4.892, p = 0.02), and the administration of steroids (HR 2.258, CI 1.907-5.032, p = 0.024) were also significant predictors of survival. CONCLUSIONS:Low levels of physical activity during the waiting period for LT led to decreased survival times among LT candidates.
journal_name
Surg Todayjournal_title
Surgery todayauthors
Komatsu T,Oshima A,Chen-Yoshikawa TF,Harashima SI,Aoyama A,Inagaki N,Date Hdoi
10.1007/s00595-017-1542-6subject
Has Abstractpub_date
2017-12-01 00:00:00pages
1526-1532issue
12eissn
0941-1291issn
1436-2813pii
10.1007/s00595-017-1542-6journal_volume
47pub_type
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