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Role of riboswitches in gene regulation and their potential for algal biotechnology.

Abstract：

:Riboswitches are regulatory elements in messenger RNA to which specific ligands can bind directly in the absence of proteins. Ligand binding alters the mRNA secondary structure, thereby affecting expression of the encoded protein. Riboswitches are widespread in prokaryotes, with over 20 different effector ligands known, including amino acids, cofactors, and Mg(2+) ions, and gene expression is generally regulated by affecting translation or termination of transcription. In plants, fungi, and microalgae, riboswitches have been found, but only those that bind thiamine pyrophosphate. These eukaryotic riboswitches operate by causing alternative splicing of the transcript. Here, we review the current status of riboswitch research with specific emphasis on microalgae. We discuss new riboswitch discoveries and insights into the underlying mechanism of action, and how next generation sequencing technology provides the motivation and opportunity to improve our understanding of these rare but important regulatory elements. We also highlight the potential of microalgal riboswitches as a tool for synthetic biology and industrial biotechnology.

journal_name

J Phycol

journal_title

Journal of phycology

authors

Nguyen GT,Scaife MA,Helliwell KE,Smith AG

doi

10.1111/jpy.12416

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

320-8

issue

3

eissn

0022-3646

issn

1529-8817

journal_volume

52

pub_type

杂志文章,评审

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