Financial Relationships With Industry Among National Comprehensive Cancer Network Guideline Authors.

abstract：Importance:Although aspirin is recommended for the prevention of colorectal cancer (CRC) among adults aged 50 to 59 years, recent data from a randomized clinical trial suggest a lack of benefit and even possible harm among older adults. Objective:To examine the association between aspirin use and the risk of incident ...

journal_title：JAMA oncology

authors： Guo CG,Ma W,Drew DA,Cao Y,Nguyen LH,Joshi AD,Ng K,Ogino S,Meyerhardt JA,Song M,Leung WK,Giovannucci EL,Chan AT

更新日期：2021-01-21 00:00:00

abstract：IMPORTANCE:A recent randomized radiation dose-escalation trial in unresectable stage III non-small-cell lung cancer (NSCLC) (Radiation Therapy Oncology Group [RTOG] 0617) showed a lower survival rate in the high-dose radiation therapy (RT) arm (74 Gy) than in the low-dose arm (60 Gy) with concurrent chemotherapy. OBJE...

journal_title：JAMA oncology

authors： Movsas B,Hu C,Sloan J,Bradley J,Komaki R,Masters G,Kavadi V,Narayan S,Michalski J,Johnson DW,Koprowski C,Curran WJ Jr,Garces YI,Gaur R,Wynn RB,Schallenkamp J,Gelblum DY,MacRae RM,Paulus R,Choy H

更新日期：2016-03-01 00:00:00

abstract：Importance:Hereditary cancer syndromes infer high cancer risks and require intensive cancer surveillance, yet the prevalence and spectrum of these conditions among unselected patients with early-onset colorectal cancer (CRC) is largely undetermined. Objective:To determine the frequency and spectrum of cancer susceptib...

journal_title：JAMA oncology

authors： Pearlman R,Frankel WL,Swanson B,Zhao W,Yilmaz A,Miller K,Bacher J,Bigley C,Nelsen L,Goodfellow PJ,Goldberg RM,Paskett E,Shields PG,Freudenheim JL,Stanich PP,Lattimer I,Arnold M,Liyanarachchi S,Kalady M,Heald B,Gre

更新日期：2017-04-01 00:00:00

abstract：Importance:In clinical practice, patients with primary metastatic renal cell carcinoma (mRCC) have been offered cytoreductive nephrectomy (CN) followed by targeted therapy, but the optimal sequence of surgery and systemic therapy is unknown. Objective:To examine whether a period of sunitinib therapy before CN improves...

journal_title：JAMA oncology

authors： Bex A,Mulders P,Jewett M,Wagstaff J,van Thienen JV,Blank CU,van Velthoven R,Del Pilar Laguna M,Wood L,van Melick HHE,Aarts MJ,Lattouf JB,Powles T,de Jong Md PhD IJ,Rottey S,Tombal B,Marreaud S,Collette S,Collette L,

更新日期：2019-02-01 00:00:00

abstract：Importance:Pathologic nodal stage is the most significant prognostic factor in resectable non-small cell lung cancer (NSCLC). The International Association for the Study of Lung Cancer NSCLC staging project revealed intercontinental differences in N category-stratified survival. These differences may indicate differenc...

journal_title：JAMA oncology

authors： Smeltzer MP,Faris NR,Ray MA,Osarogiagbon RU

更新日期：2018-01-01 00:00:00

abstract：Importance:The association between increasing body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) and risk of breast cancer is unique in cancer epidemiology in that a crossover effect exists, with risk reduction before and risk increase after menopause. The inverse association w...

journal_title：JAMA oncology

authors： Premenopausal Breast Cancer Collaborative Group.,Schoemaker MJ,Nichols HB,Wright LB,Brook MN,Jones ME,O'Brien KM,Adami HO,Baglietto L,Bernstein L,Bertrand KA,Boutron-Ruault MC,Braaten T,Chen Y,Connor AE,Dorronsoro M,Dossu

更新日期：2018-11-01 00:00:00

abstract：IMPORTANCE:Objective response rate (ORR) is an increasingly important end point for accelerated development of highly active anticancer therapies, yet its relationship to regulatory approval is not well characterized. OBJECTIVE:To identify circumstances in which a high ORR is associated with regulatory approval, and t...

journal_title：JAMA oncology

authors： Oxnard GR,Wilcox KH,Gonen M,Polotsky M,Hirsch BR,Schwartz LH

更新日期：2016-06-01 00:00:00

abstract：Importance:The oligometastatic paradigm postulates that patients with a limited number of metastases can be treated with ablative local therapy to each site of disease with curative intent. Stereotactic ablative radiotherapy (SABR) is a radiation technique that has become widely used in this setting. However, prospecti...

journal_title：JAMA oncology

authors： Lehrer EJ,Singh R,Wang M,Chinchilli VM,Trifiletti DM,Ost P,Siva S,Meng MB,Tchelebi L,Zaorsky NG

更新日期：2021-01-01 00:00:00

abstract：Importance:The risk stratification of adrenocortical carcinoma (ACC) based on tumor proliferation index and stage is limited. Adjuvant therapy after surgery is recommended for most patients. Pan-genomic studies have identified distinct molecular groups closely associated with outcome. Objective:To compare the molecula...

journal_title：JAMA oncology

authors： Assié G,Jouinot A,Fassnacht M,Libé R,Garinet S,Jacob L,Hamzaoui N,Neou M,Sakat J,de La Villéon B,Perlemoine K,Ragazzon B,Sibony M,Tissier F,Gaujoux S,Dousset B,Sbiera S,Ronchi CL,Kroiss M,Korpershoek E,De Krijger

更新日期：2019-07-11 00:00:00

abstract：Importance:Tumor-treating fields (TTFields) therapy improves both progression-free and overall survival in patients with glioblastoma. There is a need to assess the influence of TTFields on patients' health-related quality of life (HRQoL). Objective:To examine the association of TTFields therapy with progression-free ...

journal_title：JAMA oncology

authors： Taphoorn MJB,Dirven L,Kanner AA,Lavy-Shahaf G,Weinberg U,Taillibert S,Toms SA,Honnorat J,Chen TC,Sroubek J,David C,Idbaih A,Easaw JC,Kim CY,Bruna J,Hottinger AF,Kew Y,Roth P,Desai R,Villano JL,Kirson ED,Ram Z,

更新日期：2018-04-01 00:00:00

abstract：Importance:Administration of anti-programmed cell death protein 1 (anti-PD-1) is now standard therapy in advanced non-small cell lung cancer (NSCLC). However, immune checkpoint inhibitors, including anti-PD-1, have not been assessed in patients with subclinical disease with advanced NSCLC, and no useful clinical biomar...

journal_title：JAMA oncology

authors： Toi Y,Sugawara S,Sugisaka J,Ono H,Kawashima Y,Aiba T,Kawana S,Saito R,Aso M,Tsurumi K,Suzuki K,Shimizu H,Domeki Y,Terayama K,Nakamura A,Yamanda S,Kimura Y,Honda Y

更新日期：2019-03-01 00:00:00

abstract：Importance:Colorectal cancer (CRC) incidence and mortality among individuals younger than 50 years (early-onset CRC) are increasing. The reasons for such increases are largely unknown, although the increasing prevalence of obesity may be partially responsible. Objective:To investigate prospectively the association bet...

journal_title：JAMA oncology

authors： Liu PH,Wu K,Ng K,Zauber AG,Nguyen LH,Song M,He X,Fuchs CS,Ogino S,Willett WC,Chan AT,Giovannucci EL,Cao Y

更新日期：2019-01-01 00:00:00

abstract：Importance:Approximately 50% of the risk for the development of testicular germ cell tumors (TGCTs) is estimated to be heritable, but no mendelian TGCT predisposition genes have yet been identified. It is hypothesized that inherited pathogenic DNA repair gene (DRG) alterations may drive susceptibility to TGCTs. Object...

journal_title：JAMA oncology

authors： AlDubayan SH,Pyle LC,Gamulin M,Kulis T,Moore ND,Taylor-Weiner A,Hamid AA,Reardon B,Wubbenhorst B,Godse R,Vaughn DJ,Jacobs LA,Meien S,Grgic M,Kastelan Z,Markt SC,Damrauer SM,Rader DJ,Kember RL,Loud JT,Kanetsky PA,

更新日期：2019-04-01 00:00:00

abstract：Importance:Single-agent immune checkpoint inhibition has not shown activities in advanced refractory colorectal cancer (CRC), other than in those patients who are microsatellite-instability high (MSI-H). Objective:To evaluate whether combining programmed death-ligand 1 (PD-L1) and cytotoxic T-lymphocyte-associated pro...

journal_title：JAMA oncology

authors： Chen EX,Jonker DJ,Loree JM,Kennecke HF,Berry SR,Couture F,Ahmad CE,Goffin JR,Kavan P,Harb M,Colwell B,Samimi S,Samson B,Abbas T,Aucoin N,Aubin F,Koski SL,Wei AC,Magoski NM,Tu D,O'Callaghan CJ

更新日期：2020-06-01 00:00:00

abstract：IMPORTANCE:Statin use has been associated with improved prostate cancer outcomes. Dehydroepiandrosterone sulfate (DHEAS) is a precursor of testosterone and a substrate for SLCO2B1, an organic anionic transporter. We previously demonstrated that genetic variants of SLCO2B1 correlated with time to progression (TTP) durin...

journal_title：JAMA oncology

authors： Harshman LC,Wang X,Nakabayashi M,Xie W,Valenca L,Werner L,Yu Y,Kantoff AM,Sweeney CJ,Mucci LA,Pomerantz M,Lee GS,Kantoff PW

更新日期：2015-07-01 00:00:00

abstract：Importance:The role of cytoreductive nephrectomy in patients with metastatic renal cancer in the era of targeted therapy is uncertain. Objective:To establish the safety and efficacy of upfront pazopanib therapy prior to cytoreductive nephrectomy in previously untreated patients with metastatic clear cell renal cancer....

journal_title：JAMA oncology

authors： Powles T,Sarwar N,Stockdale A,Sarker SJ,Boleti E,Protheroe A,Jones R,Chowdhury S,Peters J,Oades G,O'Brien T,Sullivan M,Aitchison M,Beltran L,Worth D,Smith K,Michel C,Trevisan G,Harvey-Jones E,Wimalasingham A,Sahde

更新日期：2016-10-01 00:00:00

abstract：Importance:Lay navigators in the Patient Care Connect Program support patients with cancer from diagnosis through survivorship to end of life. They empower patients to engage in their health care and navigate them through the increasingly complex health care system. Navigation programs can improve access to care, enhan...

journal_title：JAMA oncology

authors： Rocque GB,Pisu M,Jackson BE,Kvale EA,Demark-Wahnefried W,Martin MY,Meneses K,Li Y,Taylor RA,Acemgil A,Williams CP,Lisovicz N,Fouad M,Kenzik KM,Partridge EE,Patient Care Connect Group.

更新日期：2017-06-01 00:00:00

abstract：IMPORTANCE:Positive phase 3 cancer clinical trials are widely hailed, while trials with negative results are often interpreted as scientific failures. We hypothesized that these interpretations would be reflected in the scientific literature. OBJECTIVE:To compare the scientific impact of positive vs negative phase 3 c...

journal_title：JAMA oncology

authors： Unger JM,Barlow WE,Ramsey SD,LeBlanc M,Blanke CD,Hershman DL

更新日期：2016-07-01 00:00:00

abstract：Importance:Low-cost sequencing of multiple genes is increasingly available for cancer risk assessment. Little is known about uptake or outcomes of multiple-gene sequencing after breast cancer diagnosis in community practice. Objective:To examine the effect of multiple-gene sequencing on the experience and treatment ou...

journal_title：JAMA oncology

authors： Kurian AW,Ward KC,Hamilton AS,Deapen DM,Abrahamse P,Bondarenko I,Li Y,Hawley ST,Morrow M,Jagsi R,Katz SJ

更新日期：2018-08-01 00:00:00

abstract：IMPORTANCE:Multiple myeloma has been classified as exhibiting "limited or suggestive evidence" of an association with exposure to herbicides in Vietnam War veterans. Occupational studies have shown that other pesticides (ie, insecticides, herbicides, fungicides) are associated with excess risk of multiple myeloma and i...

journal_title：JAMA oncology

authors： Landgren O,Shim YK,Michalek J,Costello R,Burton D,Ketchum N,Calvo KR,Caporaso N,Raveche E,Middleton D,Marti G,Vogt RF Jr

更新日期：2015-11-01 00:00:00

abstract：IMPORTANCE:The anti-PD-1 therapeutic antibody, nivolumab, has demonstrated clinical activity in patients with advanced melanoma. The activity of nivolumab in subgroups of patients with tumors which have wild-type BRAF kinase vs patients with tumors having mutant BRAF has not systematically been explored in a large data...

journal_title：JAMA oncology

authors： Larkin J,Lao CD,Urba WJ,McDermott DF,Horak C,Jiang J,Wolchok JD

更新日期：2015-07-01 00:00:00

abstract：IMPORTANCE:Instituting widespread measurement of outcomes for cancer hospitals using administrative data is difficult owing to lack of cancer-specific information such as disease stage. OBJECTIVE:To evaluate the performance of hospitals that treat patients with cancer using Medicare data for outcome ascertainment and ...

journal_title：JAMA oncology

authors： Pfister DG,Rubin DM,Elkin EB,Neill US,Duck E,Radzyner M,Bach PB

更新日期：2015-12-01 00:00:00

abstract：Importance:While adjuvant hormonal therapy (HT) reduces mortality for women with nonmetastatic breast cancer, nonadherence to HT is common. Objective:We investigated the association between patterns of prior nonadherence to medications for chronic conditions with HT nonadherence. Design, Setting, and Participants:For...

journal_title：JAMA oncology

authors： Neugut AI,Zhong X,Wright JD,Accordino M,Yang J,Hershman DL

更新日期：2016-10-01 00:00:00

abstract：Importance:Metastatic colorectal cancer (mCRC) is heterogeneous, and primary tumors arising from different regions of the colon are clinically and molecularly distinct. Objective:To examine the prognostic and predictive value of primary tumor location in patients with RAS wild-type (wt) mCRC treated with first-line fl...

journal_title：JAMA oncology

authors： Tejpar S,Stintzing S,Ciardiello F,Tabernero J,Van Cutsem E,Beier F,Esser R,Lenz HJ,Heinemann V

更新日期：2017-02-01 00:00:00

abstract：Importance:Randomized trials in breast cancer have demonstrated the clinical benefits of adjuvant endocrine therapy (AET) in preventing recurrence and death. The examination of concordance with AET guidelines at a national level as a measure of quality of care is important. Objective:To investigate temporal trends and...

journal_title：JAMA oncology

authors： Daly B,Olopade OI,Hou N,Yao K,Winchester DJ,Huo D

更新日期：2017-07-01 00:00:00

abstract：Importance:Evidence for application of stereotactic and other conformal radiotherapy techniques in treating brain tumors is largely based on data derived from dosimetric, retrospective, or small prospective studies. Therefore, we conducted a randomized clinical trial of stereotactic conformal radiotherapy (SCRT) compar...

journal_title：JAMA oncology

authors： Jalali R,Gupta T,Goda JS,Goswami S,Shah N,Dutta D,Krishna U,Deodhar J,Menon P,Kannan S,Sarin R

更新日期：2017-10-01 00:00:00

abstract：IMPORTANCE:BRCA genetic testing has substantial public health impact, yet little is known of the real-world experiences of the more than 100 000 Americans undergoing testing annually. OBJECTIVE:To identify factors associated with use of BRCA testing, assess whether delivery of genetic counseling and testing services a...

journal_title：JAMA oncology

authors： Armstrong J,Toscano M,Kotchko N,Friedman S,Schwartz MD,Virgo KS,Lynch K,Andrews JE,Aguado Loi CX,Bauer JE,Casares C,Bourquardez Clark E,Kondoff MR,Molina AD,Abdollahian M,Walker G,Sutphen R

更新日期：2015-12-01 00:00:00

abstract：Importance:Remarkable progress has occurred in understanding the pathophysiology and in developing improved personalized therapies in adult acute lymphoblastic leukemia (ALL). Observations:We searched MEDLINE (1990-2018), the American Society of Clinical Oncology, and American Society of Hematology websites (2010-2018...

journal_title：JAMA oncology

authors： Jabbour E,Pui CH,Kantarjian H

更新日期：2018-10-01 00:00:00

abstract：Importance:Androgen-deprivation therapy (ADT) plus docetaxel is the standard of care in hormone-naive metastatic prostate cancer but is of uncertain benefit in a nonmetastatic, high-risk prostate cancer setting. Objective:To assess the benefit of ADT plus docetaxel in patients presenting with rising prostate-specific ...

journal_title：JAMA oncology

authors： Oudard S,Latorzeff I,Caty A,Miglianico L,Sevin E,Hardy-Bessard AC,Delva R,Rolland F,Mouret L,Priou F,Beuzeboc P,Gravis G,Linassier C,Gomez P,Voog E,Muracciole X,Abraham C,Banu E,Ferrero JM,Ravaud A,Krakowski I,L

更新日期：2019-05-01 00:00:00

abstract：Importance:The evidence for concurrent chemoradiotherapy (CT-RT) in International Federation of Gynecology and Obstetrics (FIGO) stage IIIB squamous cell carcinoma of the uterine cervix is not robust. This study reports the final results of a randomized clinical trial of concurrent cisplatin-based CT-RT and radiotherap...

journal_title：JAMA oncology

authors： Shrivastava S,Mahantshetty U,Engineer R,Chopra S,Hawaldar R,Hande V,Kerkar RA,Maheshwari A,Shylasree TS,Ghosh J,Bajpai J,Gurram L,Gulia S,Gupta S,Gynecologic Disease Management Group.

更新日期：2018-04-01 00:00:00