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Ryanodine Receptor 1 Polymorphism Is Not Associated with Aneurysmal Subarachnoid Hemorrhage or its Clinical Sequelae.

Abstract：

OBJECTIVE:The pathophysiologic mechanisms underlying cerebral vasospasm after aneurysmal subarachnoid hemorrhage (aSAH) remain poorly understand. Ryanodine receptors (RYR) are intracellular calcium channels involved in the regulation of vascular smooth muscle cells and cerebrovascular tone and diameter. Previous work reported an association between an RYR polymorphism and cerebral vasospasm. Here, we sought to assess the impact of that RYR polymorphism on aSAH and its clinical sequelae. METHODS:Blood samples from all patients enrolled in the CARAS (Cerebral Aneurysm Renin Angiotensin System) study were used for genetic evaluation. The RYR1 single nucleotide polymorphism (SNP) rs35364374 was detected using 5'exonuclease (Taqman) genotyping assays. Associations between the RYR1 polymorphism and aSAH and its clinical sequelae were analyzed. RESULTS:Samples from 149 patients with aSAH and 50 controls were available for analysis. Multivariable regression analysis did not show an association of RYR1 SNP rs35364374 with aSAH. Moreover, there was no association of RYR1 SNP rs35364374 with clinical vasospasm, delayed cerebral ischemia, functional outcome at discharge, or functional outcome at last follow-up. CONCLUSIONS:Contrary to a previous report, the RYR1 SNP rs35364374 was not associated with aSAH or its clinical sequelae.

journal_name

World Neurosurg

journal_title

World neurosurgery

authors

Hendrix P,Foreman PM,Harrigan MR,Fisher WS Rd,Vyas NA,Lipsky RH,Lin M,Walters BC,Tubbs RS,Shoja MM,Pittet JF,Mathru M,Griessenauer CJ

doi

10.1016/j.wneu.2016.12.132

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

190-194

eissn

1878-8750

issn

1878-8769

pii

S1878-8750(17)30004-9

journal_volume

100

pub_type

杂志文章,多中心研究

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