An integrated approach: advances in the use of Clostridium for biofuel.

Abstract:

:Almost 90% of our energy comes from fossil fuels, which are both limited and polluting, hence the need to find alternative sources. Biofuels can provide a sustainable and renewable source of energy for the future. Recent significant advances in genetic engineering and fermentation technology have made microbial bio-based production of chemicals from renewable resources more viable. Clostridium species are considered as promising micro-organisms for the production of a wide range of chemicals for industrial use. However, a number of scientific challenges still need to be overcome to facilitate an economically viable production system. These include the use of cheap non-food-based substrates, a better understanding of the metabolic processes involved, improvement of strains through genetic engineering and innovation in process technology. This paper reviews recent developments in these areas, advancing the use of Clostridium within an industrial context especially for the production of biofuels.

authors

Kök MS

doi

10.1080/02648725.2016.1168075

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

69-81

issue

1-2

eissn

0264-8725

issn

2046-5556

journal_volume

31

pub_type

杂志文章,评审
  • Biopharmaceuticals from plants: a multitude of options for posttranslational modifications.

    abstract::In 1982 the first recombinant therapeutic, human insulin, was introduced into the market and started a new branch of pharmaceutical development, manufacture, and therapy options. To date, more than 130 recombinant protein therapeutics have been approved by the US Food and Drug Administration (FDA) and many more are be...

    journal_title:Biotechnology & genetic engineering reviews

    pub_type: 杂志文章,评审

    doi:10.5661/bger-25-315

    authors: Warzecha H

    更新日期:2008-01-01 00:00:00

  • Beyond landraces: developing improved germplasm resources for underutilized species - a case for Bambara groundnut.

    abstract::The potential for underutilized crops (also known as minor, neglected or orphan crops) to improve food and nutrition security has been gaining prominence within the research community in recent years. This is due to their significance for diversified agricultural systems which is a necessary component of future agricu...

    journal_title:Biotechnology & genetic engineering reviews

    pub_type: 杂志文章,评审

    doi:10.1080/02648725.2014.992625

    authors: Aliyu S,Massawe F,Mayes S

    更新日期:2014-10-01 00:00:00

  • Application and use of Inulin as a tool for therapeutic drug delivery.

    abstract::Inulin is a polysaccharide with an extensive range of therapeutic uses such as a vehicle in drug delivery vehicle, as a diagnostic/analytical tool or as a dietary fibre with additional health benefits. In the main, much research has focussed on inulin as a drug delivery carrier for colon-targeted drug delivery. The ju...

    journal_title:Biotechnology & genetic engineering reviews

    pub_type: 杂志文章,评审

    doi:10.5661/bger-28-33

    authors: Imran S,Gillis RB,Kok MS,Harding SE,Adams GG

    更新日期:2012-01-01 00:00:00

  • Xylanases: from biology to biotechnology.

    abstract::Xylan is the main carbohydrate found in the hemicellulosic fraction of plant tissues and accounts for one third of all renewable organic carbon available on earth. Xylanase, the major component of an enzymatic consortium, acts in nature by depolymerizing xylan molecules into monomeric pentosan units that are used by b...

    journal_title:Biotechnology & genetic engineering reviews

    pub_type: 杂志文章,评审

    doi:10.1080/02648725.1996.10647925

    authors: Prade RA

    更新日期:1996-01-01 00:00:00

  • Metabolic status of pluripotent cells and exploitation for growth in stirred suspension bioreactors.

    abstract::Pluripotent stem cells are of great interest in the field of regenerative medicine. Recent studies have shown that they maintain a glycolytic metabolic status while pluripotent and wholesale changes to mitochondrial and metabolic profile occur during differentiation. This article reviews the process and how this may b...

    journal_title:Biotechnology & genetic engineering reviews

    pub_type: 杂志文章,评审

    doi:10.1080/02648725.2013.801233

    authors: Day B,Rancourt DE

    更新日期:2013-01-01 00:00:00

  • Patent reform in the United States.

    abstract::The recent financial meltdown has muted the patent reform debate in the United States. But given that President Obama, as well as many members of Congress, support patent reform, we expect the debate to resurface. In this essay, we look carefully at reports from three prestigious organizations which have been enormous...

    journal_title:Biotechnology & genetic engineering reviews

    pub_type: 杂志文章,评审

    doi:10.5661/bger-26-389

    authors: Mills A,Tereskerz P

    更新日期:2010-01-01 00:00:00

  • Supply of nutrients to cells in engineered tissues.

    abstract::A proper supply of nutrients to cells in engineered tissues is paramount for an optimal development and survival of these tissues. However, especially in tissues with clinically relevant sizes, the mass transport of nutrients into the tissue is often insufficient to sustain all the cells within the tissue. This is not...

    journal_title:Biotechnology & genetic engineering reviews

    pub_type: 杂志文章,评审

    doi:10.5661/bger-26-163

    authors: Rouwkema J,Koopman B,Blitterswijk C,Dhert W,Malda J

    更新日期:2010-01-01 00:00:00

  • Zebrafish as a model for systems biology.

    abstract::Zebrafish offer a unique vertebrate model for research areas such as drug development, disease modeling and other biological exploration. There is significant conservation of genetics and other cellular networks among zebrafish and other vertebrate models, including humans. Here we discuss the recent work and efforts ...

    journal_title:Biotechnology & genetic engineering reviews

    pub_type: 杂志文章,评审

    doi:10.1080/02648725.2013.801238

    authors: Mushtaq MY,Verpoorte R,Kim HK

    更新日期:2013-01-01 00:00:00

  • 16 years research on lactic acid production with yeast - ready for the market?

    abstract::The use of plastic produced from non-renewable resources constitutes a major environmental problem of the modern society. Polylactide polymers (PLA) have recently gained enormous attention as one possible substitution of petroleum derived polymers. A prerequisite for high quality PLA production is the provision of opt...

    journal_title:Biotechnology & genetic engineering reviews

    pub_type: 杂志文章,评审

    doi:10.1080/02648725.2010.10648152

    authors: Sauer M,Porro D,Mattanovich D,Branduardi P

    更新日期:2010-01-01 00:00:00

  • siRNA: novel therapeutics from functional genomics.

    abstract::Long-term research on RNA interference led to an unfathomed understanding of the mechanism of siRNA-mediated silencing and finally siRNA has emerged as a powerful therapeutic tool. With siRNAs virtually every gene in the human genome contributing to a disease becomes amenable to regulation, thus opening unprecedented ...

    journal_title:Biotechnology & genetic engineering reviews

    pub_type: 杂志文章,评审

    doi:10.1080/02648725.2014.921495

    authors: Joshi BH,Pachchigar KP

    更新日期:2014-10-01 00:00:00

  • Gene expression - time to change point of view?

    abstract::Analysis of transcription profiles has been the focus of genome wide characterization of gene expression during the last decade. Downstream of transcription, regulation of translation represents a less explored step in the gene expression pathway. Differential translation can be caused by differential ribosome recruit...

    journal_title:Biotechnology & genetic engineering reviews

    pub_type: 杂志文章,评审

    doi:10.5661/bger-25-77

    authors: Larsson O,Nadon R

    更新日期:2008-01-01 00:00:00

  • Current viral-mediated gene transfer research for treatment of Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is the most common form of dementia and has affected millions of individuals worldwide. The hallmarks of AD include the amyloid beta plaque deposits, tau neurofibrillary tangles, altered neuronal signaling, alongside decline in memory and cognitive functions. Conventional drug therapies do exi...

    journal_title:Biotechnology & genetic engineering reviews

    pub_type: 杂志文章

    doi:10.1080/02648725.2018.1523521

    authors: Sasmita AO

    更新日期:2019-04-01 00:00:00