Abstract：
:The local field potential (LFP) is a signal reflecting the electrical activity of neurons surrounding the electrode tip. Synchronization between LFP signals provides important details about how neural networks are organized. Synchronization between two distant brain regions is hard to detect using linear synchronization algorithms like correlation and coherence. Synchronization likelihood (SL) is a non-linear synchronization-detecting algorithm widely used in studies of neural signals from two distant brain areas. One drawback of non-linear algorithms is the heavy computational burden. In the present study, we proposed a graphic processing unit (GPU)-accelerated implementation of an SL algorithm with optional 2-dimensional time-shifting. We tested the algorithm with both artificial data and raw LFP data. The results showed that this method revealed detailed information from original data with the synchronization values of two temporal axes, delay time and onset time, and thus can be used to reconstruct the temporal structure of a neural network. Our results suggest that this GPU-accelerated method can be extended to other algorithms for processing time-series signals (like EEG and fMRI) using similar recording techniques.
journal_name
Neurosci Bulljournal_title
Neuroscience bulletinauthors
Zhao ZF,Li XZ,Wan Ydoi
10.1007/s12264-017-0175-5subject
Has Abstractpub_date
2017-12-01 00:00:00pages
653-663issue
6eissn
1673-7067issn
1995-8218pii
10.1007/s12264-017-0175-5journal_volume
33pub_type
杂志文章abstract：OBJECTIVE:Despite accumulating evidence on a role of immune cells and their associated chemicals in mechanisms of pain, few studies have addressed the potential role of chemokines in the descending facilitation of persistent pain. The present study was undertaken to test the hypothesis that the chemokine (C-C motif) li...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-012-1218-6
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:To determine whether aquaporin-4 (AQP4) regulates acute lesions, delayed lesions, and the associated microglial activation after cryoinjury to the brain. METHODS:Brain cryoinjury was applied to AQP4 knockout (KO) and wild-type mice. At 24 h and on days 7 and 14 after cryoinjury, lesion volume, neuronal loss,...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-012-1063-7
更新日期：2012-02-01 00:00:00
abstract：OBJECTIVE:To observe the effects of gamma-aminobutyric acid (GABA) on the electric activities of pain-excited neurons (PEN) in nucleus accumbens (NAc) in central nervous system (CNS) of morphine-dependent rats. METHODS:After GABA or the GABA(A)-receptor antagonist, bicuculline (Bic), was injected into cerebral ventric...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-008-0227-y
更新日期：2008-10-01 00:00:00
abstract：OBJECTIVE:To investigate effects of K(ATP) opener on the expressions of caspase-12 mRNA and protein, and to explore the role of endoplasmic reticulum (ER) stress pathway in the mechanism of K(ATP) opener protecting against neuronal apoptosis after cerebral ischemia-reperfusion. METHODS:Two hundred rats were randomly d...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-008-1227-7
更新日期：2008-02-01 00:00:00
abstract：:Intracerebral injections of tracers or viral constructs in rodents are now commonly used in the neurosciences and must be executed perfectly. The purpose of this article is to update existing protocols for intracerebral injections in adult and neonatal mice. Our procedure for stereotaxic injections in adult mice allow...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-015-1558-0
更新日期：2015-12-01 00:00:00
abstract：:Continuous dopaminergic stimulation (CDS) is a prominent therapeutic concept for the treatment of Parkinson's disease (PD), which proposes that continuous brain dopamine-receptor stimulation, rather than intermittent doses of oral L-dopa, prevents or manages L-dopa-induced dyskinesias (LIDs). In the normal situation, ...
journal_title：Neuroscience bulletin
pub_type： 杂志文章,评审
doi：10.1007/s12264-013-1329-8
更新日期：2013-10-01 00:00:00
abstract：:Voltage-gated sodium channels (VGSCs) are transiently expressed in cochlear hair cells before hearing onset and play an indispensable role in shaping spontaneous activity. In this study, we showed that Na+ currents shaped the spontaneous action potentials in developing mouse inner hair cells (IHCs) by decreasing the t...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-019-00415-3
更新日期：2020-01-01 00:00:00
abstract：:Schizophrenia is considered to be a disorder of brain connectivity, which might result from a disproportionally impaired rich-club organization. The rich-club is composed of highly interconnected hub regions that play crucial roles in integrating information between different brain regions. Few studies have yet invest...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-017-0151-0
更新日期：2017-08-01 00:00:00
abstract：:To investigate the behavioral and biomolecular similarity between neuralgia and depression, a trigeminal neuralgia (TN) mouse model was established by constriction of the infraorbital nerve (CION) to mimic clinical trigeminal neuropathic pain. A mouse learned helplessness (LH) model was developed to investigate inesca...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-017-0131-4
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:Aquaporin-4 (AQP4), the main water channel protein in the brain, plays a critical role in water homeostasis and brain edema. Here, we investigated its role in the inflammatory responses after focal cerebral ischemia. METHODS:In AQP4-knockout (KO) and wild-type mice, focal cerebral ischemia was induced by 30 ...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-012-1281-z
更新日期：2012-12-01 00:00:00
abstract：:The enteric nervous system (ENS) controls the function of the gastrointestinal tract and has been implicated in various diseases, including Parkinson's disease (PD). PD is a neurodegenerative disease with Lewy bodies (LBs) and Lewy neurites (LNs) as the main pathological features. In addition to the typical motor symp...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-017-0179-1
更新日期：2017-10-01 00:00:00
abstract：:Parkinson's disease (PD) is one of the commonest neurodegenerative disorders characterized by the loss of dopaminergic (DAergic) neurons in the substantia nigra and the appearance of Lewy bodies (LBs), whose cytoplasmic inclusions are highly enriched with ubiquitin, synphilin-1, alpha-synuclein and parkin. Synphilin-1...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：
更新日期：2006-07-01 00:00:00
abstract：:Orexin, released from the hypothalamus, has been implicated in various basic non-somatic functions including feeding, the sleep-wakefulness cycle, emotion, and cognition. However, the role of orexin in somatic motor control is still little known. Here, using whole-cell patch clamp recording and immunostaining, we inve...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-017-0127-0
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:The present study aims to investigate the role of protein kinase C delta subtype (PKCdelta) phosphorylation in the process of 6-hydroxydopamine (6-OHDA)-induced dopaminergic cell death, and demonstrate the molecular basis of neurological disorders, such as Parkinson's disease. METHODS:The pheochromocytoma (P...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-009-0416-3
更新日期：2009-08-01 00:00:00
abstract：:Febrile seizures (FSs) are the most common convulsions in childhood. Studies have demonstrated a significant relationship between a history of prolonged FSs during early childhood and temporal sclerosis, which is responsible for intractable mesial temporal lobe epilepsy. It has been shown that interleukin-1β (IL-1β) i...
journal_title：Neuroscience bulletin
pub_type： 杂志文章,评审
doi：10.1007/s12264-012-1240-8
更新日期：2012-06-01 00:00:00
abstract：:Autophagy plays a vital role in cerebral ischemia and may be a potential target for developing novel therapy for stroke. In this study, we constructed an autophagy-related pathway network by analyzing the genes related to autophagy and ischemic stroke, and the risk genes were screened. Two autophagy-related modules we...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-015-1547-3
更新日期：2015-08-01 00:00:00
abstract：:Insomnia is a common sleep disorder among older adults, and a risk factor for poor physical and mental health. However, the relationship between insomnia and cognitive health is not well understood. Here, we review observational studies that have investigated whether insomnia is associated with deficits in objective c...
journal_title：Neuroscience bulletin
pub_type： 杂志文章,评审
doi：10.1007/s12264-019-00401-9
更新日期：2020-01-01 00:00:00
abstract：:The role of awareness in differential delay eyeblink conditioning (DEC) remains controversial. Here, we investigated the involvement of awareness in differential DEC with a soft or a loud tone as the conditioned stimulus (CS). In the experiment, 36 participants were trained in differential DEC with a soft tone (60 dB)...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-013-1400-5
更新日期：2014-06-01 00:00:00
abstract：:The blood-brain barrier (BBB) maintains homeostasis by blocking toxic molecules from the circulation, but drugs are blocked at the same time. When the dose is increased to enhance the drug concentration in the central nervous system, there are side-effects on peripheral organs. In recent years, genetic therapeutic age...
journal_title：Neuroscience bulletin
pub_type： 杂志文章,评审
doi：10.1007/s12264-014-1498-0
更新日期：2015-04-01 00:00:00
abstract：:Oligodendrocytes, the myelin-forming cells for axon ensheathment in the central nervous system, are critical for maximizing and maintaining the conduction velocity of nerve impulses and proper brain function. Demyelination caused by injury or disease together with failure of myelin regeneration disrupts the rapid prop...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-013-1318-y
更新日期：2013-04-01 00:00:00
abstract：:In the present study, we investigated the mechanisms underlying the mediation of iron transport by L-type Ca2+ channels (LTCCs) in primary cultured ventral mesencephalon (VM) neurons from rats. We found that co-treatment with 100 µmol/L FeSO4 and MPP+ (1-methyl-4-phenylpyridinium) significantly increased the productio...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-019-00424-2
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVE:The ventral part of the medial prefrontal cortex (mPFC) plays an important role in initiation and control of voluntary movement, mood and cognition. However, after the degeneration of the nigrostriatal pathway, the neuronal activity of the ventral mPFC and the role of serotonin(1A) (5-hydroxytryptamine, 5-HT(...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-007-0047-5
更新日期：2007-11-01 00:00:00
abstract：:Schizophrenia (SZ) is a devastating mental disorder afflicting 1% of the population. Recent genome-wide association studies (GWASs) of SZ have identified >100 risk loci. However, the causal variants/genes and the causal mechanisms remain largely unknown, which hinders the translation of GWAS findings into disease biol...
journal_title：Neuroscience bulletin
pub_type： 杂志文章,评审
doi：10.1007/s12264-014-1488-2
更新日期：2015-02-01 00:00:00
abstract：:Studies estimating eye movements have demonstrated that non-human primates have fixation patterns similar to humans at the first sight of a picture. In the current study, three sets of pictures containing monkeys, humans or both were presented to rhesus monkeys and humans. The eye movements on these pictures by the tw...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-013-1367-2
更新日期：2013-10-01 00:00:00
abstract：:The human TLX gene encodes an orphan nuclear receptor predominantly expressed in the central nervous system. Tailess and Tlx, the TLX homologues in Drosophila and mouse, play essential roles in body-pattern formation and neurogenesis during early embryogenesis and perform crucial functions in maintaining stemness and ...
journal_title：Neuroscience bulletin
pub_type： 杂志文章,评审
doi：10.1007/s12264-015-0004-7
更新日期：2016-02-01 00:00:00
abstract：:Cross-modal selective attention enhances the processing of sensory inputs that are most relevant to the task at hand. Such differential processing could be mediated by a swift network reconfiguration on the macroscopic level, but this remains a poorly understood process. To tackle this issue, we used a behavioral para...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-020-00550-2
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVE:The globus pallidus plays a critical role in movement regulation. Previous studies have indicated that the globus pallidus receives neurotensinergic innervation from the striatum, and systemic administration of a neurotensin analog could produce antiparkinsonian effects. The present study aimed to investigate...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-010-0518-y
更新日期：2010-10-01 00:00:00
abstract：:The integrity of the neuronal membrane is crucial for its function and cellular survival; thus, ineffective repair of damaged membranes may be one of the key elements underlying the neuronal degeneration and overall functional loss that occurs after spinal cord injury (SCI). it has been shown that polyethylene glycol ...
journal_title：Neuroscience bulletin
pub_type： 杂志文章,评审
doi：10.1007/s12264-013-1364-5
更新日期：2013-08-01 00:00:00
abstract：:The concept of pain has remained a topic of long debate since its emergence in ancient times. The initial ideas of pain were formulated in both the East and the West before 1800. Since 1800, due to the development of experimental sciences, different theories of pain have emerged and become central topics of debate. Ho...
journal_title：Neuroscience bulletin
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s12264-011-0139-0
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVE:Glutamic acid decarboxylase 2 (GAD65) is a gamma-aminobutyric acid (GABA) synthetase. This study aimed to construct a recombinant lentivirus-rGAD65 (rLV-rGAD65) vector containing the cDNA of rat GAD65 (rGAD65) and assess its functional activity in vitro and in vivo. METHODS:cDNA of rGAD65 was amplified by RT...
journal_title：Neuroscience bulletin
pub_type： 杂志文章
doi：10.1007/s12264-011-1840-8
更新日期：2011-12-01 00:00:00
