Inference from the stationary distribution of allele frequencies in a family of Wright-Fisher models with two levels of genetic variability.

Abstract:

:The distribution of allele frequencies obtained from diffusion approximations to Wright-Fisher models is useful in developing intuition about the population level effects of evolutionary processes. The statistical properties of the stationary distributions of K-allele models have been extensively studied under neutrality or under selection. Here, we introduce a new family of Wright-Fisher models in which there are two hierarchical levels of genetic variability. The genotypes composed of alleles differing from each other at the selected level have fitness differences with respect to each other and evolve under selection. The genotypes composed of alleles differing from each other only at the neutral level have the same fitness and evolve under neutrality. We show that with an appropriate scaling of the mutation parameter with respect to the number of alleles at each level, the frequencies of alleles at the selected and the neutral level are conditionally independent of each other, conditional on knowing the number of alleles at all levels. This conditional independence allows us to simulate from the joint stationary distribution of the allele frequencies. We use these simulated frequencies to perform inference on parameters of the model with two levels of genetic variability using Approximate Bayesian Computation.

journal_name

Theor Popul Biol

authors

Ferguson JM,Buzbas EO

doi

10.1016/j.tpb.2018.03.004

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

78-87

eissn

0040-5809

issn

1096-0325

pii

S0040-5809(18)30060-1

journal_volume

122

pub_type

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