Severe Pain Due to Paraspinal Abscess Formation in Two Patients with Squamous-Cell Carcinoma of the Head and Neck after Multimodal Treatment Including Cetuximab.

Abstract:

BACKGROUND:Patients with squamous-cell carcinoma of the head and neck (SCCHN) on palliative therapy usually have a bad prognosis and suffer from various symptoms. With increasing use of targeted agents in cancer patients at the end of life, the correct assignment of therapy-related symptoms becomes increasingly difficult as cancer-related symptoms usually increase as well. CASE REPORT:We report on 2 cases of patients with SCCHN who received multimodal treatment including palliative therapy with cetuximab. Both patients developed severe thoracic and cervicothoracic pain following treatment. In both cases, extensive paraspinal abscess formation proved to be the underlying cause. One patient was treated conservatively; the other one had to undergo surgical intervention. CONCLUSIONS:Awareness of multifaceted therapy-related complications is mandatory when patients receive multimodal treatment including targeted therapies. Unexplained pain syndromes in this context should raise suspicions concerning possible infectious complications and should lead to early use of magnetic resonance imaging.

journal_name

Oncol Res Treat

authors

Gerlach C,Pretzell I,Lieberknecht E,Mattyasovszky S,Weber M

doi

10.1159/000486758

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

395-398

issue

6

eissn

2296-5270

issn

2296-5262

pii

000486758

journal_volume

41

pub_type

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