Abstract:
Background/purpose:The effect of aspirin on bone regeneration remains controversial. This study aimed to determine the effect of various concentrations of aspirin on cell viability, osteogenic differentiation, cell cycle, and apoptosis on ST2 cells to find an effective range of aspirin for bone regeneration induction. Materials and methods:Cell viability was measured with MTT assay after being stimulated with aspirin for 1 day, 2 days, 3 days, 5 days, and 7 days. Alkaline phosphatase (ALP) activity was measured after cells were treated for 1 day, 3 days, and 7 days. Expression of runt-related transcription factor 2 (Runx-2) was evaluated using Western-blot analysis at 3 days and 7 days. Flow cytometry was used for cell cycle and apoptosis measurement after cells were treated for 48 hours. Results:Lower concentrations of aspirin (1μΜ and 10μM) promoted cell growth and increased ALP levels and Runx-2 expression, while higher concentrations (100μΜ and 1000μΜ) inhibited cell growth (P < 0.05), and lost their effect on ALP activity after 3 days, while even showing an inhibitory effect on the expression of Runx-2. Aspirin at a concentration of 100μM promoted cell mitosis from the S phase to the G2/M phase, and 1000μM arrested the cell cycle in the resting phase G0/G1 (P < 0.05). Parallel apoptosis/necrosis studies showed the percentage of cells in apoptosis decreased dramatically at any dose of aspirin. Conclusion:A lower dosage of aspirin could promote ST2 cell growth, osteogenic differentiation, and inhibit their apoptosis which indicates that aspirin can be used as an alternative for bone regeneration.
journal_name
J Dent Scijournal_title
Journal of dental sciencesauthors
Du M,Pan W,Duan X,Yang P,Ge Sdoi
10.1016/j.jds.2016.03.009subject
Has Abstractpub_date
2016-09-01 00:00:00pages
315-322issue
3eissn
1991-7902issn
2213-8862pii
S1991-7902(16)30017-4journal_volume
11pub_type
杂志文章abstract:Background/purpose:Medication-related osteonecrosis of the jaws (MRONJ) is an unusual but quite serious complication. However, its mechanism remains unclear, and its treatment protocol is still controversial. Materials and methods:Our study involved 201 osteonecrosis of the jaw (ONJ) patients from September 2006 to Ma...
journal_title:Journal of dental sciences
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
abstract:Background/purpose:Composite resin is currently the most widely used dental restoration material. Previous studies have demonstrated that the application of Chlorhexidine (CHX) on the dentin surface after acid etching can result in an improvement in the integrity and stability of tooth restoration through time. In orde...
journal_title:Journal of dental sciences
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abstract:Background/purpose:Helicobacter pylori (H. pylori) infection is the most common in the world and is associated with various gastrointestinal pathologies, including chronic gastritis, peptic ulcers, and gastric cancer. The prevalence is associated with socioeconomic conditions, with this infection being more common in d...
journal_title:Journal of dental sciences
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更新日期:2019-06-01 00:00:00
abstract:Background/purpose:This study was undertaken to document the knowledge, attitude and behavior among family caregivers, and to identify the related factors influencing their behavior in promoting their and children's oral health. Materials and methods:A cross-sectional study was conducted to collect self-administered q...
journal_title:Journal of dental sciences
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更新日期:2017-12-01 00:00:00
abstract:Background/purpose:Endodontic treatment success depends on treatment of all root canals, but the implementation status is affected by various factors. We examined whether the fee payment change affected the extra root canal endodontic treatment (EXRCT) in adult teeth in the National Health Insurance (NHI) system of Tai...
journal_title:Journal of dental sciences
pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
abstract:Background/purpose:The reliability and accuracy of linear distance and voxel density (VD) measurements are very important in dentistry. The purpose of this study was to assess the accuracy and reliability of linear distances and VD measurements of cone-beam computed tomography (CBCT) at different voxel sizes. Material...
journal_title:Journal of dental sciences
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journal_title:Journal of dental sciences
pub_type: 杂志文章
doi:10.1016/j.jds.2018.05.002
更新日期:2018-12-01 00:00:00
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journal_title:Journal of dental sciences
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更新日期:2021-01-01 00:00:00
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journal_title:Journal of dental sciences
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更新日期:2021-01-01 00:00:00
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journal_title:Journal of dental sciences
pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
abstract:Background/purpose:The aim of this study was to explore the presence and variability of oral Candida in adolescents before and during treatment with fixed orthodontic appliances. Materials and methods:A total of 50 patients aged 10-18 years old were randomly selected for this study. Microorganism samples were obtained...
journal_title:Journal of dental sciences
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更新日期:2016-03-01 00:00:00
abstract:Background/purpose:Anatomical features of the lingual undercut region is a potential factor that might increase the risk of displacement of a tooth or fragment. The aim of this study was to report the normal anatomical relationship of impacted lower third molar roots to the lingual cortex and soft tissues of mandible a...
journal_title:Journal of dental sciences
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更新日期:2017-09-01 00:00:00
abstract:Background/purpose:The efficacy of non-surgical periodontal therapy (NSPT) has been well discussed. The aim of this study was to investigate whether the baseline clinical periodontal parameters, radiographic defect angle, and interproximal site predict the treatment outcome of NSPT. Materials and methods:A total of 39...
journal_title:Journal of dental sciences
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abstract:Background/purpose:An ideal therapeutic procedure for the treatment of gingival recession associated with an NCCL has presented a challenge to clinicians. Various dental materials and surgical approaches have been used to manage gingival recessions associated with NCCLs for the most predictable combined surgical/restor...
journal_title:Journal of dental sciences
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:Journal of dental sciences
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doi:10.1016/j.jds.2018.08.004
更新日期:2018-12-01 00:00:00
abstract:Background/purpose:Dental implants insertion can be a major factor in stress and anxiety. The aim was to evaluate the paracetamol ability to lower stress and anxiety when compared with ibuprofen during and after computer guided implant surgery utilizing CAD/CAM surgical template and a computer vision system for assessm...
journal_title:Journal of dental sciences
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更新日期:2021-01-01 00:00:00
abstract:Background/purpose:Based on 'pressure-tension theory', the application of orthodontic force to the tooth site affects the remodeling of periodontal tissue, specifically, mechanical stress induces the release of cytokines. The purpose of this research paper is to examine death receptor 3/TNF-like protein 1A/progranulin ...
journal_title:Journal of dental sciences
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
abstract:Background/purpose:Tongue pressure measurement conveys important information about eating and swallowing function. The Iowa Oral Performance Instrument® (IOPI) and KAY Swallowing Workstation® are internationally used for tongue pressure measurement, but for legal reasons cannot be used in Japan; rather the JMS tongue p...
journal_title:Journal of dental sciences
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更新日期:2021-01-01 00:00:00
abstract::Successful root canal treatment relies on correct access cavity preparation, sufficient cleaning, adequate shaping, and complete obturation. Prior to these, location of all existing canals in the tooth plays an important part in the initial treatment procedures. While most teeth have a normal morphology, we should rec...
journal_title:Journal of dental sciences
pub_type: 杂志文章
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abstract:Background/purpose:Over 250 years has been researched over the consequences of oral galvanism. Previous studies have already examined the influence on dental fixation materials. The aim of this study was to investigate the electro-chemical solubility behavior of different dental core build-up materials in a pseudo-real...
journal_title:Journal of dental sciences
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abstract:Background/purpose:One of the major educational goals in preclinical dental education is to learn tooth preparation techniques. The purpose of this study was to evaluate the influence of different preparation designs on the development of the manual dexterity of students, in order to perform a state-of-the-art tooth pr...
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更新日期:2017-03-01 00:00:00
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journal_title:Journal of dental sciences
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更新日期:2016-09-01 00:00:00
abstract:Background/purpose:Dental students are exposed to highly stressful environments, making them high-risk for burnout and depression. This study intended to investigate the burnout and depression level in senior dental students in Korea. Materials and methods:We conducted a cross-sectional questionnaire study among third...
journal_title:Journal of dental sciences
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:Journal of dental sciences
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更新日期:2016-12-01 00:00:00
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journal_title:Journal of dental sciences
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更新日期:2019-03-01 00:00:00
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journal_title:Journal of dental sciences
pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00
abstract:Background/purpose:The use of cavity treatments may help in the reduction of bacteria remaining in dentinal tubules after selective carious tissue removal. This study aimed to investigate the effect of selective carious tissue removal and treatment with either 35% phosphoric acid +0.12% chlorhexidine or dentine conditi...
journal_title:Journal of dental sciences
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pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00