Abstract:
:Oncotherapy has been revolutionised by the introduction of immune-checkpoint inhibitors including CTLA4, PD1 and PDL1 inhibitors. Patients with malignant diseases may largely benefit from these therapies, which may result in long-term remission even in the most therapy-resistant tumour types. Differences in the mode of action of the various agents may result in varying side-effect profiles. In addition to organ-specific side-effects, overt autoimmune syndromes may also develop. Our current view of oncotherapy has changed as these mostly immune-mediated side-effects highly differ from those observed previously during the administration of traditional anti-tumour compounds. These side-effects should be carefully characterized and differentiated from infections or the progression of the underlying malignancy. Fortunately, several recent recommendations have become available on the management of immune-mediated adverse events due to checkpoint-inhibitor therapy. Orv Hetil. 2019; 160(23): 887-895. :Absztrakt: A daganatterápiát forradalmasította az immuncheckpointgátlók, elsősorban a CTLA4-, PD1- és PDL1-gátlók bevezetése. Alkalmazásuk igazi nyertesei a malignus daganatos betegek: bizonyos tumorlokalizációk esetén ezek a kezelések a legnehezebben uralható rosszindulatú betegségeket is hosszú remisszióban tudják tartani. A kezelések különböző fajtáinak hatásmechanizmusában megnyilvánuló különbségek eltérő mellékhatásprofilban nyilvánulnak meg. A szervspecifikus mellékhatások mellett manifeszt autoimmun betegségek is jelentkezhetnek. A mellékhatás-management terén szemléletváltás szükséges: a szövődmények elhárítását célzó tevékenységeink során nem szabad megfeledkezni arról, hogy az immuncheckpointgátló kezelések mellékhatásai mennyire eltérnek a klasszikus gyógyszeres onkoterápiáknál megszokottól. Ezen tünetek pontos differenciálása esetleges infekciótól vagy a daganatos betegség progressziójától nélkülözhetetlen, de nem egyszerű differenciáldiagnosztikai feladat. Szerencsére számos ajánlás jelent meg az immuncheckpointgátló kezelés mellékhatásainak elhárításával, kezelésével kapcsolatban. Orv Hetil. 2019; 160(23): 887–895.
journal_name
Orv Hetiljournal_title
Orvosi hetilapauthors
Szekanecz É,Szekanecz Zdoi
10.1556/650.2019.31392subject
Has Abstractpub_date
2019-06-01 00:00:00pages
887-895issue
23eissn
0030-6002issn
1788-6120journal_volume
160pub_type
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