[Autoimmune side effects of immune-checkpoint inhibitor therapies in oncology: pathogenesis, clinic and treatment].

Abstract:

:Oncotherapy has been revolutionised by the introduction of immune-checkpoint inhibitors including CTLA4, PD1 and PDL1 inhibitors. Patients with malignant diseases may largely benefit from these therapies, which may result in long-term remission even in the most therapy-resistant tumour types. Differences in the mode of action of the various agents may result in varying side-effect profiles. In addition to organ-specific side-effects, overt autoimmune syndromes may also develop. Our current view of oncotherapy has changed as these mostly immune-mediated side-effects highly differ from those observed previously during the administration of traditional anti-tumour compounds. These side-effects should be carefully characterized and differentiated from infections or the progression of the underlying malignancy. Fortunately, several recent recommendations have become available on the management of immune-mediated adverse events due to checkpoint-inhibitor therapy. Orv Hetil. 2019; 160(23): 887-895. :Absztrakt: A daganatterápiát forradalmasította az immuncheckpointgátlók, elsősorban a CTLA4-, PD1- és PDL1-gátlók bevezetése. Alkalmazásuk igazi nyertesei a malignus daganatos betegek: bizonyos tumorlokalizációk esetén ezek a kezelések a legnehezebben uralható rosszindulatú betegségeket is hosszú remisszióban tudják tartani. A kezelések különböző fajtáinak hatásmechanizmusában megnyilvánuló különbségek eltérő mellékhatásprofilban nyilvánulnak meg. A szervspecifikus mellékhatások mellett manifeszt autoimmun betegségek is jelentkezhetnek. A mellékhatás-management terén szemléletváltás szükséges: a szövődmények elhárítását célzó tevékenységeink során nem szabad megfeledkezni arról, hogy az immuncheckpointgátló kezelések mellékhatásai mennyire eltérnek a klasszikus gyógyszeres onkoterápiáknál megszokottól. Ezen tünetek pontos differenciálása esetleges infekciótól vagy a daganatos betegség progressziójától nélkülözhetetlen, de nem egyszerű differenciáldiagnosztikai feladat. Szerencsére számos ajánlás jelent meg az immuncheckpointgátló kezelés mellékhatásainak elhárításával, kezelésével kapcsolatban. Orv Hetil. 2019; 160(23): 887–895.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Szekanecz É,Szekanecz Z

doi

10.1556/650.2019.31392

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

887-895

issue

23

eissn

0030-6002

issn

1788-6120

journal_volume

160

pub_type

杂志文章
  • [Surgical management of liver echinococcosis].

    abstract::In the last ten years 62 patients were operated on by the authors because of liver echinococcosis. Each of the infections caused by echinococcus granulosus. In the course of the examination ultrasonography, abdominal X-ray, Casoni test and ELISA were used. Angiography and ERCP were applied only to answer special quest...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Petri A,Karácsonyi S,Kalmár NK,Leindler L

    更新日期:1993-07-04 00:00:00

  • [The role of real-time three-dimensional echocardiography in the evaluation of hypertrophic cardiomyopathy].

    abstract::Hypertrophic cardiomyopathy is a relatively common hereditary disorder, which is associated with cardiac morphologic and functional alterations. Echocardiography is a non-invasive, simple and easy-to-learn method to evaluate patients with cardiomyopathy. The aim of this review paper is to demonstrate the possible diag...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/OH.2009.28710

    authors: Nemes A,Geleijnse ML,Soliman OI,Anwar AM,Vletter WB,McGhie JS,Csanády M,Forster T,Ten Cate FJ

    更新日期:2009-10-18 00:00:00

  • [Databases in neurological diseases: overview of international examples in multiple sclerosis].

    abstract::Vast amounts of data are created during routine patient care which are stored in unstructured digital and hardcopy formats in healthcare institutions. Analysis of large databases help to define the healthcare needs of the population and to organize healthcare services for specific diseases. As a model, we selected mul...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/650.2019.31273

    authors: Iljicsov A,Simó M,Tegze N,Szócska M,Mátyus P,Bereczki D

    更新日期:2019-01-01 00:00:00

  • [The first clinical experiences in Hungary with a new effective antibiotic (linezolid) effective against Gram-positive infections].

    abstract:INTRODUCTION:The occurrence of gram-positive infections caused by multiresistant organisms has increased significantly in general, particularly among the surgical patients, and only a few effective antibiotics are available. A new and effective, synthetic antibiotic, against gram-positives is the oxazolidinon group, th...

    journal_title:Orvosi hetilap

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Pulay I,Konkoly TM,Zsirka KA,Csapó Z,Flautner L,Tihanyi T

    更新日期:2003-01-05 00:00:00

  • [Fungal esophagitis].

    abstract::The gastrointestinal mucosa is one of the principal portal of entry in systemic fungal infections. Esophagitis is the most frequent among the fungal infections of the gastrointestinal tract. The etiologic factors of fungal infections are various Candida species, most frequently Candida albicans. Due to the large numbe...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Péter Z,Telegdy L

    更新日期:2002-07-21 00:00:00

  • [Two cases of hyperthyroidism and ophthalmopathy following hypothyroidism].

    abstract::Two cases of Graves' disease emerging in previously hypothyroid patients are described. After two years of thyroid hormone substitution due to 'idiopathic' hypothyreosis (patient 1) and Hashimoto's thyroiditis (patient 2), the substitution had to be stopped. The persisting clinical and laboratory signs of immune hyper...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Kálmán K,Nagy E,Leövey A

    更新日期:1990-07-08 00:00:00

  • Importance of the imaging techniques in the management of COVID-19-infected patients

    abstract::Critical-care physicians are facing a challenging process in healthcare due to the overwhelming case number of hypoxic respiratory failure patients. Pneumonia has an utmost importance in the primary pathomechanism of the development of critical illness in the COVID-19 patients. Thus, imaging techniques are situated in...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/650.2020.31814

    authors: Lovas A,Hankovszky P,Korsós A,Kupcsulik S,Molnár T,Szabó Z,Babik B

    更新日期:2020-04-01 00:00:00

  • [A(H1N1)v cases of the 2009/2010 and 2010/2011 influenza seasons in the Medical and Health Sciences Centre of Debrecen University].

    abstract:UNLABELLED:The swine-origin new influenza variant A(H1N1) emerged in 2009 and changed the epidemiology of the 2009/2010 influenza season globally and at national level. AIMS:The aim of the authors was to analyse the cases of two influenza seasons. METHODS:The Medical and Health Sciences Centre of Debrecen University ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2012.29329

    authors: Orosi P,Szidor J,Tóthné Tóth T,Kónya J

    更新日期:2012-04-29 00:00:00

  • [Causes, diagnosis and therapy of habitual abortions].

    abstract::Recent knowledge concerning the etiology of habitual abortions is reviewed by the author. The anatomic, genetic, endocrine and immunologic causes furthermore the assumed role of maternal diseases and infections are summarised. Besides diagnostic procedures and therapeutic possibilities are discussed. ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Gardó S

    更新日期:1993-11-28 00:00:00

  • [Pharmacological reduction of bleeding during hip endoprosthetic replacement].

    abstract:INTRODUCTION:Endoprosthetic replacement of the large joints is accompanied by major bleeding. During the last few years several authors reported the perioperative administration of tranexamic acid and its beneficial effect on reducing the blood loss. OBJECTIVES:In the present study, the author studied the effect of in...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2012.29455

    authors: de Jonge T

    更新日期:2012-10-14 00:00:00

  • [The importance of molecular genetic diagnosis of Martin-Bell disease in genetic counseling].

    abstract::The female consultant had two mentally retarded boys from her two marriages. The clinical symptoms and Fra-X chromosomes indicated their Martin-Bell disease. The daughter of the consultant is healthy and Fra-X negative. She is pregnant and insisted on her molecular genetic diagnosis due to an international collaborati...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Horváth M,Tímár L,Karcagi V,Czeizel E

    更新日期:1997-03-02 00:00:00

  • [Use of the short (5-item) version of the WHO well-being questionnaire in first year students of Semmelweis University].

    abstract:INTRODUCTION:Studies on well-being of students in higher education are in the centre of international research interest, because adult health as a value plays an important role in the life of future generation. AIM:The authors studied variables that affect the value of well-being (satisfaction with life, student succe...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2016.30572

    authors: Dinyáné Szabó M,Pusztai G

    更新日期:2016-10-01 00:00:00

  • [Acute viral hepatitis: pathogenesis and clinical manifestations].

    abstract::This is a review of several mechanisms in the acute and chronic progress of viral hepatitis. Investigation of these mechanisms may have an important role in the diagnosis and treatment of chronic hepatitis. Clinical features of acute non-A, non-B hepatitis were studied in 110 patients. Most of the patients had a surgi...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Dalmi L,Weisz G,Kovács J

    更新日期:1992-07-05 00:00:00

  • [Suicidal behavior in the elderly. Review of results at the Pécs Center of the WHO/EURO Multicenter Study on Suicide].

    abstract::The authors examined the characteristics of old suicide attempters (over 65 years) with special regard to organic and depressive disorders and sociodemographic features. Within the framework of the WHO/EURO Multicentre Study on Parasuicide data of 849 suicide attempts were collected during three years. Comparing old a...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Osváth P,Fekete S

    更新日期:2001-06-03 00:00:00

  • [Renal papillary necrosis in a diabetic patient].

    abstract::The authors present a case of a young diabetic patient with acute symptoms of pyelonephritis. The specific and permanent antibiotic treatment was ineffective and septic condition developed complicated by renal papillary necrosis. Because of the strong flank pain extensive examinations were done with negative result. T...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Neuwirth G,Kahler A,Kereszter P,Madai E

    更新日期:2001-03-25 00:00:00

  • [Immunohistologic changes of the intestinal mucosa in chronic inflammatory bowel diseases].

    abstract::In the pathogenesis of inflammatory bowel disease abnormally increased immune reactions in the intestinal mucosa play a basic role. The revealing of these reactions was facilitated by the rapidly spreading immunohistological methods in last decades. This review discusses in detail the characteristic distribution of ly...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Arató A

    更新日期:2002-12-08 00:00:00

  • [Thalidomide (Contergan) induced limb deficiency in Hungary?].

    abstract:CASE REPORT:A 47 year old female with severe deficiency of three limbs visited our Genetic Counselling Clinic and asked us to give her a certificate that her complex limb deficiency was caused by thalidomide (Contergan). According to her explanation, her mother used this drug during pregnancy which was given to her by ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2009.28641

    authors: Gidai J,Bács E,Czeizel E

    更新日期:2009-06-21 00:00:00

  • [Removal of epulis using CO2 laser (clinicopathologic analysis and surgical experience)].

    abstract::From analyzing the epulis patient population of 40 years it could be established that from the 1019 lesions 12.8% relapsed, in 40% of surgical interventions, beside the extraction of the tooth involved. For the removal of epulis an own method has been elaborated by the authors. As a first step the tumour is excised by...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Gáspár L,Szabó G

    更新日期:1990-11-25 00:00:00

  • [The measureable clinical signs of malnutrition: the clinical significance of body composition - bioimpedance - analysis].

    abstract::Undernutrition, or more precisely: malnutrition results in worse outcome in clinical practice. Recognition and treatment of different forms of malnutrition are not unconditionally easy in the daily routine, however, it could lead to significant improvement in the outcome. This review summarizes the most frequent forms...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/OH.2014.30050

    authors: Török É,Harsányi L

    更新日期:2014-12-21 00:00:00

  • [Dysmenorrhea in adolescent girls].

    abstract:INTRODUCTION:Dysmenorrhea is highly prevalent during adolescence but the incidence of this disease is very often underestimated. Depending on different measurement methods 20-90% of adolescent girls report dysmenorrhea. OBJECTIVES:This study examined the prevalence of dysmenorrhea among high-school female adolescent s...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Juhász AG,Vincze G,Krasznai Z,Csorba R,Major T

    更新日期:2005-01-02 00:00:00

  • [Decreased first-phase secretion of insulin may play a role in the development of insulin resistance].

    abstract::Decreased first-phase secretion of insulin may play a role in the development of insulin resistance. In the development of type 2 diabetes an abnormal function of the beta-cells and insulin resistance of liver, fat cells and muscle play the main role. An early sign of beta-cell damage can be the loss of first-phase in...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Wittmann I,Soltész G,Jermendy G,Nagy J

    更新日期:2004-11-07 00:00:00

  • [Infections and use of antibiotics in residents of long-term care facilities in Hungary].

    abstract:INTRODUCTION:Healthcare associated infections and antimicrobial use are common among residents of long-term care facilities. Faced to the lack of standardized data, the European Centre for Disease Prevention and Control funded a project with the aim of estimating prevalence of infections and antibiotic use in European ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2014.29876

    authors: Szabó R,Böröcz K

    更新日期:2014-06-08 00:00:00

  • [Rare late complication of transcystic drainage].

    abstract::The authors performed 3539 successful endoscopic retrograde cholangio-panreatographies between 1982 and 1992. In 1160 (32.7%) of the cases was revealed some kind of pathological condition. In connection with one case, following conventional cholecystectomy, a very rare complication was diagnosed by endoscopic means. T...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Novák J,Ottlakán A,Pásztor P,Gurzó Z,Kovács J,Libor J

    更新日期:1994-11-27 00:00:00

  • [Effectivity of the Nissen fundoplication and the influencing factors of the success. Results at the Medical Centre of Pécs depending on the indications and symptoms].

    abstract:INTRODUCTION:Gastroesophageal reflux disease is one of the most common gastrointestinal diseases in developed countries. Besides the conservative modalities, surgery plays an increasing role in the treatment of the disease. AIM:Our aim was to investigate and compare the surgical and 6-month follow-up data of patients ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2018.31056

    authors: Varjú P,Horváth ÖP,Papp A,Gede N,Czimmer J

    更新日期:2018-06-01 00:00:00

  • [Prospective study of K-cell activity in patients with malignant gynecologic tumors. Effect of radiation therapy].

    abstract::K cell activity was measured in the enzyme-like kinetic model of cytotoxicity against O, Rh (D) positive erythrocytes in 127 patients with carcinoma of the uterine cervix, 55 with carcinoma of the corpus uteri and 30 with malignant tumors of the ovary. The control groups included 62 healthy age matched women and 39 pa...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Siklós P,Pete I,Hercz P,Ungár L,Vigváry Z,Ringwald G,Bakács T

    更新日期:1989-05-07 00:00:00

  • [Favourable effects of kidney transplantation on vascular condition of patients: Potential prognostic significance of non-invasive measurement of arterial stiffness].

    abstract:INTRODUCTION:Development of atherosclerosis is accelerated in kidney transplant patients. Impaired metabolic pathways have complex effect on the arterial wall which can be measured by non-invasive techniques. Only few data are available on the change of stiffness parameters in the postoperative course. Therefore, in th...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Kovács DÁ,Asztalos L,Laczik R,Fedor R,Szabó L,Lőcsey L,Soltész P

    更新日期:2016-06-12 00:00:00

  • [Acute myocardial infarction mortality in a hospital department during the last decades].

    abstract::Authors surveyed the data of 2677 patients with acute myocardial infarction treated in cardiological department between 1970 and 1993. Activity of Coronary Care Unit (has been working from 1974) reduced the earlier hospital mortality in general internal medicine possibilities with 50%. Main cause of this reduction was...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Katona A,Deli L,Hutter K

    更新日期:1995-06-18 00:00:00

  • [Prevention of atrial fibrillation by atrial-based pacemaker implantation].

    abstract::A large number of studies have demonstrated the long term disadvantage of single lead ventricular pacing in sick sinus syndrome. Ventricular pacing mode predicts chronic atrial fibrillation in patients with preimplant paroxysmal atrial fibrillation. The goal of the report was to study the effectiveness of single atria...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Lörincz I,Vaszily M,Szabó Z,Horváth G,Kovács P,Polgár P,Karányi Z,Wórum F

    更新日期:1999-10-24 00:00:00

  • [Helicobacter pylori in benign gastroduodenal diseases].

    abstract::(A light- and electronmicroscopic study). We have examined the occurrence of Helicobacter pylori (HP) in 2937 gastric antral biopsy specimens from 979 patients with upper gastrointestinal symptoms. The incidence of HP proved to be 50.5%. The endoscopic diagnoses were: gastritis (62 cases), gastric erosion (425), gastr...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Joós A,Németh A,Zsolnay G,Kövári E,Papp J

    更新日期:1995-04-02 00:00:00

  • [The future of pathology--from the viewpoint of clinical pathology].

    abstract::Pathology is one of the fundamental diagnostic fields of medicine, its position has changed and will undergo transformation in the 21st century due to the introduction of new methods. Theoretically, pathology was based upon 3 pillars: 1. the autopsies, 2. the surgical pathology, i.e. the processing and evaluation of d...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Bajtai A,Nemesánszky E

    更新日期:2002-04-28 00:00:00