Abstract:
BACKGROUND:There have been many reports on midkine as a promising marker in the diagnosis of hepatocellular carcinoma (HCC). However, the results are inconsistent and even conflicting. METHODS:This meta-analysis was performed to investigate the accuracy of midkine in the diagnosis of HCC. Meta-DiSc 1.4 software was used to extract data and to calculate the overall sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR). Data are presented as forest plots and summary receiver operating characteristic (SROC) curve analysis was used to summarize the overall test performance. RESULTS:Ten studies with a total of 753 HCC patients and 977 non-HCC patients were included. The overall pooled diagnostic data were as follows: the pooled sensitivity of 0.86 (95% confidence interval [CI]: 083-0.88), the pooled specificity of 0.75 (95% CI: 0.73-0.78), the pooled PLR of 4.71 (95% CI: 2.80-7.90), the pooled NLR of 0.18 (95% CI: 0.11-0.30), and the pooled DOR of 36.83 (95% CI: 13.56-100.05). The area under curve value was 0.9266 in the overall SROC curve. CONCLUSION:Midkine has moderate diagnostic accuracy for HCC. Due to the design limitations, results inpublished studies should be carefully interpreted. In addition, more well-designed studies with large sample sizes should be performed to rigorously evaluate the diagnostic accuracy of the MDK.
journal_name
Mol Genet Genomic Medjournal_title
Molecular genetics & genomic medicineauthors
Zhang Y,Tang J,Zhou X,Zhu SL,Li LQdoi
10.1002/mgg3.1071subject
Has Abstractpub_date
2020-02-01 00:00:00pages
e1071issue
2issn
2324-9269journal_volume
8pub_type
杂志文章,评审abstract:BACKGROUND:Over 500 epigenetic regulators have been identified throughout the human genome. Of these, approximately 30 chromatin modifiers have been implicated thus far in human disease. Recently, variants in BRPF1, encoding a chromatin reader, have been associated with a previously unrecognized autosomal dominant synd...
journal_title:Molecular genetics & genomic medicine
pub_type: 杂志文章
doi:10.1002/mgg3.665
更新日期:2019-06-01 00:00:00
abstract::Definitive diagnosis of primary hyperoxaluria (PH) currently utilizes sequential Sanger sequencing of the AGXT, GRPHR, and HOGA1 genes but efficacy is unproven. This analysis is time-consuming, relatively expensive, and delays in diagnosis and inappropriate treatment can occur if not pursued early in the diagnostic wo...
journal_title:Molecular genetics & genomic medicine
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abstract:BACKGROUND:Alport syndrome is a progressive hereditary kidney disease clinically presenting with haematuria, proteinuria, and early onset end-stage renal disease, and often accompanied by hearing loss and ocular abnormalities. The inheritance is X-linked in the majority of families and caused by sequence variants in th...
journal_title:Molecular genetics & genomic medicine
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journal_title:Molecular genetics & genomic medicine
pub_type: 杂志文章
doi:10.1002/mgg3.1255
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Wieacker-Wolff syndrome (WWS) is a congenital X-linked neuromuscular disorder, which was firstly reported in 1985. Zinc finger C4H2-type containing (ZC4H2) gene has been found to be associated with the disease pathogenesis. However, the underlying mechanism remains elusive. METHODS:Whole-exome sequencing wa...
journal_title:Molecular genetics & genomic medicine
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更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Senior-Loken syndrome is a rare genetic disorder that presents with nephronophthisis and retinal degeneration, leading to end-stage renal disease and progressive blindness. The most frequent cause of juvenile nephronophthisis is a mutation in the nephronophthisis type 1 (NPHP1) gene. NPHP1 encodes the protei...
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journal_title:Molecular genetics & genomic medicine
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更新日期:2018-01-01 00:00:00
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journal_title:Molecular genetics & genomic medicine
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更新日期:2018-05-01 00:00:00
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更新日期:2017-01-26 00:00:00
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journal_title:Molecular genetics & genomic medicine
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更新日期:2015-09-01 00:00:00
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更新日期:2019-01-01 00:00:00
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更新日期:2021-01-19 00:00:00
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journal_title:Molecular genetics & genomic medicine
pub_type: 杂志文章
doi:10.1002/mgg3.722
更新日期:2019-07-01 00:00:00
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doi:10.1002/mgg3.527
更新日期:2019-02-01 00:00:00
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journal_title:Molecular genetics & genomic medicine
pub_type: 杂志文章
doi:10.1002/mgg3.261
更新日期:2016-11-30 00:00:00
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journal_title:Molecular genetics & genomic medicine
pub_type: 杂志文章,评审
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更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:General practitioners (GPs) have an increasing role in referring patients with putative mutation in BRCA1/2 genes for genetics consultation and for long-term follow-up of mutation carriers. METHODS:We compared the expectations of the GPs' role according to BRCA1/2 mutation carriers and to GPs themselves. R...
journal_title:Molecular genetics & genomic medicine
pub_type: 临床试验,杂志文章
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journal_title:Molecular genetics & genomic medicine
pub_type: 杂志文章
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更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Fanconi anemia (FA) affects only one in 130,000 births, but has severe and diverse clinical consequences. It has been theorized that defects in the FA DNA cross-link repair complex lead to a spectrum of variants that are responsible for those diverse clinical phenotypes. METHODS:Using NextGen sequencing, we...
journal_title:Molecular genetics & genomic medicine
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更新日期:2018-11-01 00:00:00
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journal_title:Molecular genetics & genomic medicine
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journal_title:Molecular genetics & genomic medicine
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更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Preeclampsia is a serious pregnancy-specific syndrome with incompletely understood pathogenesis. Previous study has demonstrated that the decreased CXCR2 in preeclamptic placentas may contribute to the development of preeclampsia. The role of single nucleotide polymorphisms (SNPs) of CXCR2 gene in the pathog...
journal_title:Molecular genetics & genomic medicine
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更新日期:2019-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-24 00:00:00
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