Tailored antiplatelet agent medication in clopidogrel hyporesponsive patients before stent-assisted coiling: single-center experience.

Abstract:

PURPOSE:In patients requiring stent procedures, resistance or hyperresponsiveness to antiplatelet medications is often observed. This study aims to evaluate the efficacy and safety of tailoring medications in these patients. METHODS:This retrospective study included 223 patients who underwent endovascular treatment for intracranial aneurysm between October 2018 and October 2019. Patients were categorized as hyporesponsive, hyperresponsive, and normoresponsive groups according to the initial PRU response. For the hypo- or hyperresponders, we tailored medication by modifying the dose or changing the drug. PRUs before and after tailoring were compared in each group. PRU reponses in patients who underwent Cytochrome P450 2C19 (CYP2C19) genotyping were also determined. RESULTS:Of the 73 clopidogrel-resistant patients, the mean PRU values after tailoring showed a greater decrease in the group that switched to prasugrel (n = 56), from 223 to 131, than in the clopidogrel reloading group (n = 17), from 238 to 209. In 31 hyperresponders, PRU increased from 49 to 94 after the dose adjustment. CYP2C19 genotyping showed that PRU tended to increase as the number of mutated alleles increased. There were five (2.3%) ischemic events (three transient ischemic attacks and two minor strokes) in a mean follow-up of 8 months, but no hemorrhage. CONCLUSIONS:The stent-assisted coiling was successfully performed with acceptable range of ischemic events and without hemorrhage in all patients, including those who applied tailored medication. Low-dose prasugrel was effective for obtaining appropriate PRU values for initial medication as well as for clopidogrel-resistant patients. The genetic test did not provide reliable results in determining clopidogrel resistance.

journal_name

Neuroradiology

journal_title

Neuroradiology

authors

Kurniawan RG,Song Y,Kwon B,Ahn Y,Suh DC

doi

10.1007/s00234-020-02496-8

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

1709-1715

issue

12

eissn

0028-3940

issn

1432-1920

pii

10.1007/s00234-020-02496-8

journal_volume

62

pub_type

杂志文章
  • Primary leiomyosarcoma of the spine.

    abstract::We present a 39-year-old man with tumour of the eighth thoracic vertebra, causing compression of the spinal cord. The tumour proved to be a primary leiomyosarcoma (LMS) of bone, an uncommon neoplasm; to our knowledge this is the first report of primary LMS in the spine. The lesion was documented by plain radiography, ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00600095

    authors: Lo TH,van Rooij WJ,Teepen JL,Verhagen IT

    更新日期:1995-08-01 00:00:00

  • Peripheral cerebral aneurysm associated with a glioma.

    abstract::This 42-year-old man with acute subarachnoid, intraventricular and parenchymal hemorrhage from an angiographically and surgically confirmed successfully clipped, right splenial artery aneurysm, subsequently manifested a grade 3 astrocytoma at the site of the aneurysm. Intracranial aneurysms are recognized in associati...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00588429

    authors: Barker CS

    更新日期:1992-01-01 00:00:00

  • Computed tomography of a post traumatic spinal arachnoid cyst.

    abstract::A case of post-traumatic arachnoid spinal cyst with haemorrhagic contents is presented. CT findings were indistinguishable from those of epidural or subdural haematomas. The use of CT myelography permits a more accurate diagnosis by localizing the lesion into one of the three spaces. In our case, bleeding into a preex...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00344183

    authors: Teruel Agustin JJ,Gómez Martinench E,Castanyer Corretger F,Cando Salcines L,Davalos Errando A

    更新日期:1989-01-01 00:00:00

  • CT of malignant choroidal melanoma - morphology and perfusion characteristics.

    abstract::The computed tomographic morphology of malignant choroidal melanoma and its perfusion characteristics are described. Thirty-three static and serial CT examinations made on 29 patients with choroidal melanoma, three with pseudotumors of the macula and one with choroidal metastasis revealed the choroidal melanoma to be ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00399701

    authors: Heller M,Guthoff R,Hagemann J,Jend HH

    更新日期:1982-01-01 00:00:00

  • Correction to: Magnetic resonance imaging features of the superior cervical ganglion and expected changes after radiation therapy to the head and neck in a long-term follow-up.

    abstract::In the article "Magnetic resonance imaging features of the superior cervical ganglion and expected changes after radiation therapy to the head and neck in a long-term follow-up", one of the author names, K Chokkappan, was spelled incorrectly. ...

    journal_title:Neuroradiology

    pub_type: 已发布勘误

    doi:10.1007/s00234-020-02394-z

    authors: Ravanelli M,Tononcelli E,Leali M,Buffa I,Loke SC,Karandikar A,Chokkappan K,Yue GOC,Goh JPN,Tan TY,Farina D

    更新日期:2020-06-01 00:00:00

  • Magnetic resonance imaging and angiography of the brain in embolic left atrial myxoma.

    abstract::A case of left atrial myxoma presenting exclusively with neurological symptoms, studied with magnetic resonance imaging (MRI) combined with cerebral angiography and computed tomography (CT) is reported. Typical angiographic findings suggested the diagnosis of myxoma. MRI showed multiple ischemic lesions disseminated t...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00698841

    authors: Marazuela M,García-Merino A,Yebra M,Brasa JM,Diego J,Durántez A

    更新日期:1989-01-01 00:00:00

  • Cervical spinal canal narrowing in idiopathic syringomyelia.

    abstract:INTRODUCTION:The cervical spine in Chiari I patient with syringomyelia has significantly different anteroposterior diameters than it does in Chiari I patients without syringomyelia. We tested the hypothesis that patients with idiopathic syringomyelia (IS) also have abnormal cervical spinal canal diameters. The finding ...

    journal_title:Neuroradiology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00234-016-1701-2

    authors: Struck AF,Carr CM,Shah V,Hesselink JR,Haughton VM

    更新日期:2016-08-01 00:00:00

  • Proton MR spectroscopy in idiopathic spasmodic torticollis.

    abstract::Single-voxel proton magnetic resonance spectroscopy (1H-MRS), localised to the basal ganglia, was used to determine changes in metabolite levels in idiopathic spasmodic torticollis (IST). We examined nine patients and 13 healthy subjects. The mean values (+/- SD) of peak area ratios were: IST: N-acetyl-aspartate (NAA)...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s002340000532

    authors: Federico F,Lucivero V,Simone IL,Defazio G,De Salvia R,Mezzapesa DM,Petruzzellis M,Tortorella C,Livrea P

    更新日期:2001-07-01 00:00:00

  • Detecting damaged regions of cerebral white matter in the subacute phase after carbon monoxide poisoning using voxel-based analysis with diffusion tensor imaging.

    abstract:INTRODUCTION:The present study aimed to detect the main regions of cerebral white matter (CWM) showing damage in the subacute phase for CO-poisoned patients with chronic neurological symptoms using voxel-based analysis (VBA) with diffusion tensor imaging (DTI). METHODS:Subjects comprised 22 adult CO-poisoned patients ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-011-0958-8

    authors: Fujiwara S,Beppu T,Nishimoto H,Sanjo K,Koeda A,Mori K,Kudo K,Sasaki M,Ogasawara K

    更新日期:2012-07-01 00:00:00

  • A refined method for creating saccular aneurysms in the rabbit.

    abstract::We describe a refined animal model of human intracerebral aneurysms for testing endovascular devices for interventional neuroradiological procedures. Saccular aneurysms resulting from a stump of the right common carotid artery (CCA) were created in 15 New Zealand White rabbits by intraluminal incubation of elastase th...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-003-0976-2

    authors: Krings T,Möller-Hartmann W,Hans FJ,Thiex R,Brunn A,Scherer K,Meetz A,Dreeskamp H,Stein KP,Gilsbach JM,Thron A

    更新日期:2003-07-01 00:00:00

  • Rates and predictors of futile recanalization in patients undergoing endovascular treatment in a multicenter clinical trial.

    abstract:PURPOSE:The phenomenon of futile recanalization, defined as lack of clinical benefit despite angiographic recanalization, is an important limitation of endovascular treatment for acute ischemic stroke. We aim to characterize the occurrence and predictors of futile recanalization in the endovascular arm of the Intervent...

    journal_title:Neuroradiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00234-018-2016-2

    authors: Hussein HM,Saleem MA,Qureshi AI

    更新日期:2018-05-01 00:00:00

  • Evaluation of cerebral infarction by computed tomography with special emphasis on microinfarction.

    abstract::Computed tomography has proved to be the most effective mode of evaluating cerebral infarction in 143 documented cases. This was especially true when multiple focal infarcts were present. The incidence of contrast enhancement in acute infarcts was 88%. Concomitant acute and old infarcts were observed in 20% of cases. ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00395235

    authors: Lee KF,Chambers RA,Diamond C,Park CH,Thompson NL Jr,Schnapf D,Pripstein S

    更新日期:1978-01-01 00:00:00

  • Optic radiations evaluation in patients affected by high-grade gliomas: a side-by-side constrained spherical deconvolution and diffusion tensor imaging study.

    abstract:INTRODUCTION:The need to improve surgical efficacy in patients affected by high-grade gliomas has led to development of advanced pre-surgical MRI-based techniques such as tractography. This study investigates pre-surgical planning of optic radiations (ORs) in patients affected by occipito-temporo-parietal high-grade gl...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-016-1732-8

    authors: Mormina E,Arrigo A,Calamuneri A,Alafaci C,Tomasello F,Morabito R,Marino S,Longo M,Vinci SL,Granata F

    更新日期:2016-11-01 00:00:00

  • Experimental side-wall aneurysms: a natural history study.

    abstract::We studied the natural history of canine side-wall experimental aneurysms to determine the incidence of spontaneous aneurysm thrombosis, to serve as control data for future studies focusing on development of aneurysm occlusion devices. Bilateral common carotid artery vein patch aneurysms were surgically created in eig...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s002340050760

    authors: Kallmes DF,Altes TA,Vincent DA,Cloft HJ,Do HM,Jensen ME

    更新日期:1999-05-01 00:00:00

  • Comparison of the precision of two standardized co-ordinate systems for the quantitation of brain anatomy: preliminary results.

    abstract::We assessed reproducible definition of two standardized co-ordinate systems for intersubject analysis of brain images. The baselines in the two co-ordinate systems were a modification of the canthomeatal (mCM) line and the anterior-posterior commissural (AC-PC) line. Axial spin-echo MR images of four subjects at 1.5T ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00593507

    authors: Sandor T,Tieman J,Ong HT,Moss MB,Jolesz F,Albert M

    更新日期:1994-10-01 00:00:00

  • Endocrinological and MRI features of pituitary adenomas with marked xanthogranulomatous reaction.

    abstract:INTRODUCTION:The study aims to describe the endocrinological and magnetic resonance imaging (MRI) features of the rarely reported xanthogranulomas associated with pituitary adenoma. METHODS:Of 231 consecutive pituitary adenomas treated surgically, those with xanthogranulomatous reaction on histology were reviewed. RE...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-010-0675-8

    authors: Nishioka H,Shibuya M,Ohtsuka K,Ikeda Y,Haraoka J

    更新日期:2010-11-01 00:00:00

  • Enhancing cyst-like lesions of the white matter in tuberous sclerosis complex: a novel neuroradiological finding.

    abstract::Tuberous sclerosis complex (TSC) is an autosomal dominant condition clinically presenting with heterogenous clinical features. Multiple neuroradiological manifestations have been associated with TSC, such as tubers, radial migration lines, subependymal nodules, subependymal giant cell astrocytomas, and cyst-like lesio...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-021-02647-5

    authors: D'Amico A,Perillo T,Russo C,Ugga L,Melis D,Santoro C,Piluso G,Cinalli G

    更新日期:2021-01-22 00:00:00

  • Clival chordoma manifesting as nasal bleeding. A case report.

    abstract::Chordoma is a rare cartilaginous tumor, for which bleeding presentation is unusual. We report a case of rare hemorrhaged clival chordoma, which was diagnosed correctly by magnetic resonance imaging. A 32-year-old man presented with nasal bleeding. The tumor was totally removed via a trans-sphenoidal approach, from whi...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-005-1367-7

    authors: Kitai R,Yoshida K,Kubota T,Sato K,Handa Y,Kasahara K,Nakajima H

    更新日期:2005-05-01 00:00:00

  • Difficulties in examination of the origin of the vertebral artery by duplex and colour-coded Doppler sonography: anatomical considerations.

    abstract::Despite progress in ultrasonographic techniques visualisation of the origin of the vertebral arteries, particularly the left, by duplex and colour Doppler imaging, still poses a problem in a significant number of patients. In anatomical and radiological studies we demonstrated an anomalous origin in 6%, the left verte...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00602620

    authors: Trattnig S,Matula C,Karnel F,Daha K,Tschabitscher M,Schwaighofer B

    更新日期:1993-01-01 00:00:00

  • Role of stenosis of spinal canal in L4-L5 nerve root compression assessed by flexion-extension myelography.

    abstract::Myelographic flexion-extension studies were performed in four groups of 10 patients each, with (A) normal myelogram; (B) bilateral nerve root compression at L4-L5; (C) unilateral nerve root compression at L4-L5 and (D) nerve root compression at L5-S1. The aim of the investigation was to assess the role of spinal steno...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00342411

    authors: Wilmink JT,Penning L,van den Burg W

    更新日期:1984-01-01 00:00:00

  • Automated 3D MRI rendering of the craniofacial skeleton: using ZTE to drive the segmentation of black bone and FIESTA-C images.

    abstract:PURPOSE:Automated bone segmentation from MRI datasets would have a profound impact on clinical utility, particularly in the craniofacial skeleton where complex anatomy is coupled with radiosensitive organs. Techniques such as gradient echo black bone (GRE-BB) and short echo time (UTE, ZTE) have shown potential in this ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-020-02508-7

    authors: Eley KA,Delso G

    更新日期:2021-01-01 00:00:00

  • Trans-radial embolization of epistaxis in patients with end-stage liver disease.

    abstract:INTRODUCTION:Endovascular treatment of epistaxis in patients with bleeding disorders is challenging due to the intrinsic risk of hemorrhagic complication related to the arterial access. We describe the use of trans-radial approach for the endovascular embolization of epistaxis due to end-stage liver disease and resulta...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-011-0999-z

    authors: Tateshima S,Froehler M,Cramer R,Rastogi S,Viñuela F

    更新日期:2012-11-01 00:00:00

  • Axial diffusivity is increased in the degenerating superior cerebellar peduncles of Friedreich's ataxia.

    abstract:INTRODUCTION:Decreased fractional anisotropy (FA) demonstrated by diffusion tensor MR imaging (DTI) in areas of white matter (WM) damage is generally associated with increase of radial diffusivity, while axial diffusivity is reported to be decreased, unchanged, or increased. Aiming to better define the type of axial di...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-010-0807-1

    authors: Della Nave R,Ginestroni A,Diciotti S,Salvatore E,Soricelli A,Mascalchi M

    更新日期:2011-05-01 00:00:00

  • Transvenous embolization of a dural arteriovenous fistula of the cavernous sinus through the contralateral pterygoid plexus.

    abstract::We report a new transvenous endovascular route for treatment of dural arteriovenous fistulas of the cavernous sinus. The cavernous sinus was approached from the contralateral pterygoid plexus and embolization of a dural fistula was performed successfully with Guglielmi detachable coils. ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s002340050566

    authors: Jahan R,Gobin YP,Glenn B,Duckwiler GR,Viñuela F

    更新日期:1998-03-01 00:00:00

  • The dural tail of intracranial meningiomas on fluid-attenuated inversion-recovery images.

    abstract::We evaluated the "dural tail" associated with 48 intracranial meningiomas on fluid-attenuated inversion-recovery (FLAIR) and contrast-enhanced T1-weighted images. In 30 (62.5%), a dural tail was observed on contrast-enhanced T1-weighted images, and thickening of the dura mater and abnormal signal were identified in th...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-003-1152-4

    authors: Takeguchi T,Miki H,Shimizu T,Kikuchi K,Mochizuki T,Ohue S,Ohnishi T

    更新日期:2004-02-01 00:00:00

  • Unilateral delayed opercularization in a case of Sotos' syndrome (Cerebral Gigantism).

    abstract::A case of Sotos' syndrome (cerebral gigantism) is described. Pneumencephalography, performed at the age of 15 days, revealed abnormal separation of the opercula on the right. By comparing the contours with developmental anatomical features of this area it agreed with a foetal development of 24 weeks gestational age. B...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00346862

    authors: Barth PG,Vlasveld L,Valk J

    更新日期:1980-08-01 00:00:00

  • Duplicate origin of the vertebral artery: report of two cases.

    abstract::We report two cases showing duplicate origin of the vertebral artery; one with fenestaration of the distal portion of the left vertebral artery. ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00451774

    authors: Hashimoto H,Ohnishi H,Yuasa T,Kawaguchi S

    更新日期:1987-01-01 00:00:00

  • Cranial computed tomography of patients with malignant melanoma.

    abstract::Sixty-eight patients with malignant melanoma were examined by CCT and the findings analyzed. Cerebral metastases were detected in 19 patients. Meningiomas were found in three patients, one with neurological symptoms and two without. Typical metastases less than 10 mm in diameter were located superficially in the grey ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00346752

    authors: Holtås S,Cronqvist S

    更新日期:1981-01-01 00:00:00

  • Spontaneous dissection of the anterior inferior cerebellar artery.

    abstract::A patient presented with the clinical features of a brain stem infarct. MRI confirmed changes of infarction but also revealed an unusual lesion in the left cerebellopontine angle cistern. The evolution of this lesion on MRI, together with angiographic changes, indicated a dissecting aneurysm of the left anterior infer...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s002340000324

    authors: Hancock JH,Millar JS

    更新日期:2000-07-01 00:00:00

  • CT in autosomal dominant and idiopathic cerebellar ataxia.

    abstract::Signs of atrophy on cranial CT were investigated in 35 patients diagnosed as suffering from autosomal dominant (n = 21) or idiopathic (n = 14) cerebellar ataxia. Thirteen patients with a pure cerebellar syndrome were examined after at least 4 years of disease (mean duration 10.5 years) and were classified as cerebella...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00588712

    authors: Wittkämper A,Wessel K,Brückmann H

    更新日期:1993-01-01 00:00:00