Prolonging survival in vascularized bone allograft transplantation: developing specific immune unresponsiveness.

Abstract:

:Vascularized bone allografts (VBAs) could be useful adjuncts to the clinical reconstructive surgeon's arsenal. These grafts are known experimentally to be subject to host rejection. One way to control the rejection problem would be to develop specific immune unresponsiveness via host conditioning. Using a proven reliable model in inbred rats for studying heterotopic VBA transplantation, recipient animals were conditioned preoperatively with third-party unrelated blood, donor-specific blood (DSB) alone and with cyclosporine, and ultraviolet irradiated donor-specific blood. The combination of DSB plus cyclosporine delayed rejection of grafts across a strong histocompatibility barrier for three to four weeks. However, rejection was delayed across a weak histocompatibility barrier for five to six weeks using this same host pretreatment. The implications are that specific immunosuppression, although possible, is difficult to achieve in VBA transplantation, and that such techniques will rely on tissue-matching to minimize the genetic disparity between graft and host.

journal_name

J Reconstr Microsurg

authors

Paskert JP,Yaremchuk MJ,Randolph MA,Weiland AJ

doi

10.1055/s-2007-1006992

subject

Has Abstract

pub_date

1987-04-01 00:00:00

pages

253-63

issue

3

eissn

0743-684X

issn

1098-8947

journal_volume

3

pub_type

杂志文章
  • Diagnostic accuracy of three sensory tests for diagnosis of sensory disturbances.

    abstract:BACKGROUND:Clinical diagnosis of sensory disturbances is extremely challenging, partly because the utility of sensory tests is questionable. Transection of C7 nerve root provides an objective assessment model to determine the diagnostic accuracy of sensory tests. The purpose of this study was to investigate the diagnos...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0034-1384819

    authors: Li XM,Yang Y,Hou Y,Yang JT,Qin BG,Fu G,Gu LQ

    更新日期:2015-01-01 00:00:00

  • Role of the target in end-to-side neurorrhaphy: reinnervation of a single muscle vs. multiple muscles.

    abstract::The authors examined the effects of end-to-side neurorrhaphy for reinnervation of the musculocutaneous nerve (Group A) which innervates the biceps muscle, compared to reinnervation of the median nerve which innervates multiple muscles in a rat model. Additionally, end-to-end neurorrhaphy to the musculocutaneous nerve ...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2006-947151

    authors: Lutz BS,Ma SF,Chuang DC,Wei FC

    更新日期:2000-08-01 00:00:00

  • Free vascularized toe-joint transfer in hand reconstruction: a series of 25 patients.

    abstract::Twenty-eight vascularized toe-joint transfers performed on 25 patients were reviewed. A number of different techniques were used: proximal interphalangeal joint or metacarpophalangeal joint reconstruction, one-stage double joint transfer, and interphalangeal thumb or trapezometacarpal joint replacement. Using these ty...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1006819

    authors: Foucher G,Sammut D,Citron N

    更新日期:1990-07-01 00:00:00

  • Microsurgical Reconstruction of Large Oncologic Chest Wall Defects for Locally Advanced Breast Cancer or Osteoradionecrosis: A Retrospective Review of 26 Cases over a 5-Year Period.

    abstract:BACKGROUND:Locally advanced breast cancer (LABC) and chest wall osteoradionecrosis (ORN) often require extensive and composite tissue resection, including muscles, ribs, pleura, and lung parenchyma. As such, these cases necessitate complex reconstructive procedures for skeletal chest wall reconstruction and soft tissue...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0035-1563395

    authors: Arya R,Chow WT,Rozen WM,Patel NG,Griffiths M,Shah S,Ramakrishnan VV

    更新日期:2016-02-01 00:00:00

  • Structural and functional regeneration of muscle-related axons after transection and repair of the rat sciatic nerve using nonvascularized autologous fascia as a barrier between tibial and peroneal nerve fascicles.

    abstract::Aberrant reinnervation of target organs caused by misdirected axonal growth at the repair site is a major reason for the poor functional outcome usually seen after peripheral nerve transection and repair. This study investigates whether the criss-crossing of regenerating rat sciatic nerve axons between tibial and pero...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2004-861524

    authors: Lutz BS

    更新日期:2004-11-01 00:00:00

  • The vastus intermedius periosteal (VIP) flap: a novel flap for osteoinduction.

    abstract::Periosteum's role in fracture healing is widely recognized, and its function in bone tissue engineering shows great potential. Here we introduce a novel periosteal free flap to be used as an abundant source of periosteum in the engineering and repair of bone. The descending branch of the lateral femoral circumflex ves...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0030-1249317

    authors: Maercks RA,Runyan CM,Jones DC,Taylor JA

    更新日期:2010-07-01 00:00:00

  • Regeneration along intact nerves using nerve growth factor and ciliary neurotrophic factor.

    abstract::The purpose of this investigation was to evaluate the ability of a specific growth factor combination, nerve growth factor (NGF) and ciliary neurotrophic factor (CNTF), to enhance peripheral nerve regeneration. Eight groups of eight Sprague-Dawley rats underwent repair of a nerve gap defect: Group A (immediate repair)...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2004-833499

    authors: McCallister WV,McCallister EL,Dubois B,Trumble TE

    更新日期:2004-08-01 00:00:00

  • Endoneural and epineural blood flow evaluation with free vascularized and conventional nerve grafts in the canine.

    abstract::Blood flow distribution in conventional and vascularized canine nerve grafts was analyzed. Between 4 and 6 days after operation, blood flow at both the fascicular (endoneural) and the nerve-sheath (epineural) levels was significantly greater in the nonvascularized nerve grafts than in their vascularized counterparts (...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1007044

    authors: Daly PJ,Wood MB

    更新日期:1985-10-01 00:00:00

  • Anatomic variations in branching patterns of the axillary artery: a multidetector-row computed tomography angiography study.

    abstract::Anatomic variations in branching pattern of axillary artery (AxA) are common and typically involve subscapular artery (SsA) and posterior circumflex humeral artery (PCHA). Several skin and muscle flaps are based on the branches of AxA. Furthermore, these branches are frequently used as recipient vessels in functioning...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0033-1351354

    authors: Hattori Y,Doi K,Sakamoto S,Satbhai N

    更新日期:2013-10-01 00:00:00

  • Free vascularized fibula grafts in surgery of the upper limb.

    abstract::Twenty patients with intractable diseases in the upper extremity were treated using free vascularized fibula grafts. There were 13 men and seven women. Three patients had traumatic bone defects, five had post-traumatic nonunions, two had congenital pseudoarthroses, seven had defects after tumor resection, and three ha...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1000131

    authors: Yajima H,Tamai S,Ono H,Kizaki K,Yamauchi T

    更新日期:1999-10-01 00:00:00

  • Rationale for and efficacy of digital arterial reconstruction in scleroderma: report of two cases.

    abstract::Two patients with scleroderma, ischemic pain, non-healing digital ulceration, and digital arterial obstruction were successfully treated with peripheral sympathectomy and digital arterial reconstruction using a reversed small-caliber vein graft. Postoperatively, digital blood flow increased and ulceration healed in bo...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2002-30181

    authors: Tomaino MM,King J,Medsger T

    更新日期:2002-05-01 00:00:00

  • Mild intraoperative hypothermia reduces free tissue transfer thrombosis.

    abstract::Patients undergoing free tissue transfer are particularly susceptible to hypothermia. The goal was to investigate the impact of intraoperative core body temperature on free flap thrombosis. Two hundred twelve cases of free flap reconstruction at Yale-New Haven Hospital between 1992 and 2008 were reviewed. Free flap th...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0030-1268211

    authors: Liu YJ,Hirsch BP,Shah AA,Reid MA,Thomson JG

    更新日期:2011-02-01 00:00:00

  • The combined gracilis and semitendinosus free flap in the rat.

    abstract::A free-flap model in rats is presented, that consists of gracilis and semitendinosus muscles pedicled on the femoral vessels, in continuation with deep femoral and saphenous vessels. This flap was transferred to the contralateral side in 40 rats and yielded a 95 percent survival rate. The weight of the flaps averaged ...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1000175

    authors: Ionac M,Geishauser M

    更新日期:1998-05-01 00:00:00

  • A new design for free flap reconstruction of the tongue and oropharynx.

    abstract::Radical resection of tongue and oropharyngeal carcinomas often results in complex defects that are challenging to reconstruct. Furthermore, remaining function should not be disturbed by the reconstruction. We introduce a new flap design and monitored swallowing and speech following reconstruction of complex oral defec...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2008-1078691

    authors: Yagi S,Kamei Y,Nakayama B,Toriyama K,Torii S

    更新日期:2008-04-01 00:00:00

  • L-arginine reduces neointimal hyperplasia in cold-stored arterial allografts in a rabbit low-flow-through model.

    abstract::An "off the shelf" vascular conduit for free flap surgery that remained patent until the flap is vascularized from the recipient bed would be useful to avoid autograft donor-site morbidity and reduce operation time. To date, no successful studies of microvascular prostheses in low-flow states exist. This study investi...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-985210

    authors: Dowd MB,Hemmrich K,Morrison WA

    更新日期:2007-08-01 00:00:00

  • Forequarter amputation wound coverage with an ipsilateral, lymphedematous, circumferential forearm fasciocutaneous free flap in patients undergoing palliative shoulder-girdle tumor resection.

    abstract::Closure of massive soft-tissue defects in patients undergoing forequarter amputation for shoulder-girdle tumors may present a daunting challenge. This report describes two patients whose forequarter amputations were closed using ipsilateral, lymphedematous, circumferential forearm fasciocutaneous free flaps. ...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1006658

    authors: Zachary LS,Gottlieb LJ,Simon M,Ferguson MK,Calkins E

    更新日期:1993-03-01 00:00:00

  • Operative technique to harvest an arterial flap from the posterolateral calf region: how can we elevate a lateral gastrocnemius perforating artery flap safely?

    abstract::The posterior calf region is a useful donor site for skin or composite flaps including muscle and/or nerves. We reported the first clinical use of the lateral gastrocnemius perforating artery flap including a vascularized sural nerve in 2003. This flap was elevated based on a perforator arising from the lateral head o...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2008-1064930

    authors: Kashiwa K,Kobayashi S,Tono H,Ogino K,Kimura H

    更新日期:2008-01-01 00:00:00

  • Nerve repair at different angles of attachment: experiment in rats.

    abstract::Sixteen rats underwent two procedures to test the efficacy of oblique vs. transverse nerve repair. On the left, the peroneal nerve was transected at an oblique angle (30-degree) with subsequent oblique end-to-end repair performed. On the right, the peroneal nerve was transected at a transverse angle (90-degree) with s...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2002-36503

    authors: Yan YH,Yan JG,Sanger JR,Zhang LL,Riley DA,Matloub HS

    更新日期:2002-11-01 00:00:00

  • Post-traumatic distal nerve entrapment syndrome.

    abstract::Eleven patients with paralysis of muscle groups in the upper or lower extremity were clinically diagnosed after previous proximal direct trauma to the corresponding peripheral nerves, without complete nerve disruption. Patients were seen within an average of 8 months after trauma (minimum 3 months and maximum 2 years ...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1000087

    authors: Nassif T,Steiger E

    更新日期:1999-04-01 00:00:00

  • A simplified design of a dual island fasciocutaneous free flap for simultaneous pharyngoesophageal and anterior neck reconstruction.

    abstract::Reconstruction of the pharyngoesophagus and pharynx can be especially challenging in patients with prior irradiation, recurrent disease, and compromised or deficient anterior neck skin. The authors report their experience with seven patients who underwent pharyngoesophageal reconstruction with a new flap design that a...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2006-932504

    authors: Agarwal JP,Stenson KM,Gottlieb LJ

    更新日期:2006-02-01 00:00:00

  • Vascularized bone allografts: an experimental study in dogs.

    abstract::This study attempted to re-establish vascularization to canine allograft bone by means of the introduction of a pedicle in the medullary canal with a capillary network. The experiment showed basically that the introduction of arteries and veins with a capillary network into the medullary canal of an allograft femur pr...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1006767

    authors: Carneiro R,Malinin T

    更新日期:1991-04-01 00:00:00

  • Noninvasive tissue oximetry for flap monitoring: an initial study.

    abstract::The ideal monitoring tool to evaluate free flap success should be noninvasive, continuous, and reliable. A new device, the ViOptix Tissue Oximeter (ODISsey) based on near-infrared spectroscopy was evaluated in 30 patients undergoing autologous tissue perforator free flap breast reconstruction with continuous monitorin...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-974655

    authors: Keller A

    更新日期:2007-05-01 00:00:00

  • Impact of Obesity on Outcomes in Breast Reconstruction: A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND: Increased rates of both breast cancer and obesity have resulted in more obese women seeking breast reconstruction. Studies demonstrate that these women are at increased risk for perioperative complications. A systematic review was conducted to assess the outcomes in obese women who underwent breast reconstr...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章,meta分析,评审

    doi:10.1055/s-0038-1627449

    authors: Panayi AC,Agha RA,Sieber BA,Orgill DP

    更新日期:2018-06-01 00:00:00

  • A case of degloving injury of the whole hand reconstructed by a combination of distant flaps comprising an anterolateral thigh flap and a groin flap.

    abstract::A case of degloving injury of the whole hand reconstructed by a combination of an anterolateral thigh (ALT) flap and a groin flap applied as a pedicled distant flap was reported. Despite complications of congestion of the ALT flap and superficial infection, both flaps were severed at 4 weeks after transplantation, and...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0031-1278708

    authors: Senda H,Muro H,Terada S,Okamoto H

    更新日期:2011-06-01 00:00:00

  • The treatment of peripheral nerve injuries using irradiated allografts and temporary host immunosuppression (in a rat model).

    abstract::Irradiation of allografts prior to transplantation and host immunosuppression with cyclosporin-A were studied separately and in combination as means of lessening the rejection of transplanted peripheral nerve tissue. Lewis and Brown Norway rats were used in the animal model, as they differ at both major and minor hist...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1006834

    authors: Easterling KJ,Trumble TE

    更新日期:1990-10-01 00:00:00

  • Preliminary Outcomes of Distal IMAP and SEAP Flaps for the Treatment of Unstable Keloids Subject to Recurrent Inflammation and Infections in the Lower Sternal and Upper Abdominal Areas.

    abstract:BACKGROUND:We present the clinical application of the sixth internal mammary artery perforator (IMAP) and superior epigastric artery perforator (SEAP) flaps for the treatment of defects resulting from the excision of large lower sternal and upper abdominal keloids. Perforator selection and flap design were based solely...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0035-1556078

    authors: Wang J,Min P,Grassetti L,Lazzeri D,Zhang YX,Nicoli F,Innocenti M,Torresetti M,Levin LS,Persichetti P

    更新日期:2015-11-01 00:00:00

  • Osteomyocutaneous Free Fibula Flap Prevents Osteoradionecrosis and Osteomyelitis in Head and Neck Cancer Reconstruction.

    abstract:BACKGROUND: Osteoradionecrosis (ORN) is one of the most severe complications of free fibula reconstruction after radiotherapy. The gold standard treatment of osteomyelitis involves extensive debridement, antibiotics, and sufficiently vascularized muscle flap coverage for better circulation. Therefore, we hypothesized t...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0040-1722647

    authors: Wang KY,Liu WC,Chen CF,Chen LW,Chen HC,Yang KC

    更新日期:2021-01-31 00:00:00

  • Autotransplantation of heterodigital neurovascular free flaps for plasty of finger defects.

    abstract::The authors report eight microsurgical operations to repair soft tissue defects of the fingers using free neurovascular autografts taken from the lateral surfaces of digits 3 and 4. In seven cases, the transferred flaps survived, and one case resulted in necrosis of the transplant. Follow-ups were from one to 12 month...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1006691

    authors: Datiashvili RO,Shibaev EY,Tsagikyan AA

    更新日期:1992-03-01 00:00:00

  • Modified classification and single-stage microsurgical repair of posttraumatic infected massive bone defects in lower extremities.

    abstract::Posttraumatic infected massive bone defects in lower extremities are difficult to repair because they frequently exhibit massive bone and/or soft tissue defects, serious bone infection, and excessive scar proliferation. This study aimed to determine whether these defects could be classified and repaired at a single st...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0033-1348064

    authors: Yang YF,Xu ZH,Zhang GM,Wang JW,Hu SW,Hou ZQ,Xu DC

    更新日期:2013-11-01 00:00:00

  • Microsurgical repair of Stensen's duct using an interposition vein graft.

    abstract::Facial wounds are frequently associated with bone fractures and multiple trauma; however, disruption of the parotid gland or Stensen's duct is rare and is often associated with facial nerve palsy. Lesions are often undiagnosed on first assessment of the multiple trauma patient. If microsurgical repair of Stensen's duc...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1000078

    authors: Heymans O,Nélissen X,Médot M,Fissette J

    更新日期:1999-02-01 00:00:00