The effect of cigarette smoke, nicotine, and carbon monoxide on the permeability of the arterial wall.

Abstract:

:The association between cigarette smoking and the development of atherosclerosis is well established, but the mechanism that makes cigarettes such a potent "risk factor" is not understood. There is normally a constant insudation of plasma macromolecules into the arterial wall. Fibrinogen and lipids are two of the large molecules involved in atherosclerosis. Therefore we studied the effect of cigarette smoke, nicotine, and carbon monoxide on the permeability of the canine arterial wall to 125I-labeled fibrinogen. The results show that inhaled cigarette smoke significantly and rapidly increases the permeability of the arterial wall to fibrinogen and that this effect can be produced with carbon monoxide alone but not with intravenous nicotine.

journal_name

J Vasc Surg

authors

Allen DR,Browse NL,Rutt DL,Butler L,Fletcher C

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

139-52

issue

1

eissn

0741-5214

issn

1097-6809

pii

0741-5214(88)90387-4

journal_volume

7

pub_type

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