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Use and limitations of thrombolytic therapy in the treatment of peripheral arterial ischemia: results of a multi-institutional questionnaire.

Abstract：

:In an attempt to assess the efficacy of thrombolytic infusions for arterial ischemia, a questionnaire was distributed to 142 vascular surgeons. Data from 45 respondents who had experience with thrombolytic infusion in 623 patients were reviewed. A successful outcome was obtained in 313 of 623 patients (50.2%). Morbidity was significant, with hemorrhage requiring transfusion or operation in 125 cases (20.1%) and major amputation in 103 cases (16.5%). There were nine strokes associated with thrombolytic infusion (1.4%), six of which were fatal. Sixteen deaths were associated with thrombolytic therapy, for a mortality rate of 2.5% (16 of 623 patients). Analysis of results by grouping centers according to numbers of lytic infusions failed to show significant correlation with center experience. Furthermore, morbidity and mortality were seen in centers with both limited and extensive experience with thrombolytic infusion. The initial enthusiasm for thrombolytic infusion to treat arterial ischemia is not substantiated by our data. Carefully controlled prospective trials are needed before this method can be offered as an alternative to arterial reconstruction.

journal_name

J Vasc Surg

journal_title

Journal of vascular surgery

authors

Ricotta JJ,Green RM,DeWeese JA

doi

10.1067/mva.1987.avs0060045

subject

Has Abstract

pub_date

1987-07-01 00:00:00

pages

45-50

issue

1

eissn

0741-5214

issn

1097-6809

pii

S0741-5214(87)70021-4

journal_volume

6

pub_type

杂志文章

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