Preoperative intraincisional cefamandole reduces wound infection and postoperative inpatient stay in upper abdominal surgery.

Abstract:

:The use of preoperative intraincisional (POII) single dose antibiotic prophylaxis has the advantage of providing extremely high concentrations of antibiotic along all layers of the wound, whilst achieving adequate systemic concentrations throughout the operation. In a single blind controlled trial, 250 patients undergoing upper abdominal surgery were randomised to receive POII cefamandole (2g) or to act as control. There was one wound infection in the POII group compared with 18 in the control group (P less than 0.001). Hospital stay was reduced by an average of one day (P less than 0.02) in the antibiotic treated group.

journal_name

Ann R Coll Surg Engl

authors

Taylor TV,Dawson DL,de Silva M,Shaw SJ,Durrans D,Makin D

subject

Has Abstract

pub_date

1985-07-01 00:00:00

pages

235-7

issue

4

eissn

0035-8843

issn

1478-7083

journal_volume

67

pub_type

临床试验,杂志文章,随机对照试验
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