Improved survival of island flaps after prolonged ischemia by perfusion with superoxide dismutase.

Abstract:

:Perfusion of rat groin flaps after 10 and 11 hours of complete ischemia with superoxide dismutase, an oxygen free-radical scavenger, significantly improved the survival of these flaps. This finding provides further evidence for the important role that oxygen-derived free radicals play in ischemic injury. The study also demonstrates that while restoration of blood supply alone is not enough to ensure tissue survival after prolonged ischemia, chemical agents can be utilized to achieve viable flaps beyond what was believed to be "a point of no return".

journal_name

Plast Reconstr Surg

authors

Sagi A,Ferder M,Levens D,Strauch B

doi

10.1097/00006534-198604000-00022

subject

Has Abstract

pub_date

1986-04-01 00:00:00

pages

639-44

issue

4

eissn

0032-1052

issn

1529-4242

journal_volume

77

pub_type

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