Long-term impact of the ketogenic diet on growth and resting energy expenditure in children with intractable epilepsy.

Abstract:

AIM:The long-term effects of the ketogenic diet, a high fat diet for treating intractable epilepsy, on resting energy expenditure (REE) are unknown. The aim of this study was to evaluate the impact of 15 months of ketogenic diet treatment on growth and REE in children with intractable epilepsy. METHOD:Growth, body composition, and REE were assessed at baseline, 3 months and 15 months in 24 children (14 males, 10 females; mean age 5 y 6 mo [SD 26 mo], range 7 mo-6 y 5 mo), 10 with cerebral palsy [CP]). Fifteen were identified as ketogenic diet responders at 3 months and continued on the ketogenic diet until 15 months. These were compared to 75 healthy children (43 males, 32 females; mean age 6 y 3 mo [SD 21 mo] age range 2-9 y). REE was expressed as percentage predicted, growth as height (HAz) and weight (WAz) z-scores, and body composition as fat and fat free mass (FFM). RESULTS:HAz declined -0.2 and -0.6 from baseline to 3 months and 15 months respectively (p = 0.001), while WAz was unchanged. In ketogenic diet responders, FFM, age and CP diagnosis predicted REE (overall R(2) = 0.76, p<0.001) and REE did not change. REE adjusted for FFM was lower (p<0.01) in children with CP at baseline (mean [standard error], -143[51] kcals/d) and 15 months (-198[53] kcals/d) compared to the healthy children. INTERPRETATION:After 15 months of the ketogenic diet, linear growth status declined while weight status and REE were unchanged. REE remained reduced in children with CP.

journal_name

Dev Med Child Neurol

authors

Groleau V,Schall JI,Stallings VA,Bergqvist CA

doi

10.1111/dmcn.12462

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

898-904

issue

9

eissn

0012-1622

issn

1469-8749

journal_volume

56

pub_type

杂志文章
  • Body mass index trajectories in pediatric multiple sclerosis.

    abstract:AIM:To characterize growth trajectories of children who develop multiple sclerosis compared to typically developing, regional peers and Centers for Disease Control (CDC) normative values. METHOD:This case-control study collected weight, height, and body mass index (BMI) in 40 consecutive pediatric patients with multip...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/dmcn.14233

    authors: Brenton JN,Woolbright E,Briscoe-Abath C,Qureshi A,Conaway M,Goldman MD

    更新日期:2019-11-01 00:00:00

  • Automated movement recognition to predict motor impairment in high-risk infants: a systematic review of diagnostic test accuracy and meta-analysis.

    abstract:AIM:To assess the sensitivity and specificity of automated movement recognition in predicting motor impairment in high-risk infants. METHOD:We searched MEDLINE, Embase, PsycINFO, CINAHL, Web of Science, and Scopus databases and identified additional studies from the references of relevant studies. We included studies ...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章,评审

    doi:10.1111/dmcn.14800

    authors: Raghuram K,Orlandi S,Church P,Chau T,Uleryk E,Pechlivanoglou P,Shah V

    更新日期:2021-01-09 00:00:00

  • Reliability of the V-scope system in the measurement of arm movement in children with obstetric brachial plexus palsy.

    abstract::This study reports on a novel methodology using the V-scope to quantify elbow and shoulder movement in young children with obstetric brachial plexus palsy (OBPP), and the intra- and interreliability of this method. The V-scope, a portable, inexpensive movement analysis system, was configured in an L-shape, with two tr...

    journal_title:Developmental medicine and child neurology

    pub_type: 临床试验,杂志文章

    doi:10.1017/S001216220600199X

    authors: Bialocerkowski AE,Wrigley T,Galea M

    更新日期:2006-11-01 00:00:00

  • The jaw reflex: maturation in the neonatal period and childhood.

    abstract::The onset and development of the jaw-reflex responses were studied of 54 neonates and children in up to 15 years of age. Recordings were made with standard EMG equipment. The reflex response was constantly elicited in all but one child of 35 weeks postconceptional age. The latency times showed negative linear correlat...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1993.tb11716.x

    authors: Jääskeläinen SK

    更新日期:1993-08-01 00:00:00

  • Pacinioma of the cauda equina.

    abstract::Lesions composed of Pacinian corpuscles or showing Pacinian corpuscle differentiation have usually been described in relation to benign tumours of the peripheral nervous system or reactive hyperplastic processes. On the other hand, mature Pacinian corpuscles have occasionally been detected as part of intraspinal lumbo...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1017/S0012162206002180

    authors: Kojc N,Korsic M,Popovic M

    更新日期:2006-12-01 00:00:00

  • Foix-Chavany-Marie (anterior operculum) syndrome in childhood: a reappraisal of Worster-Drought syndrome.

    abstract::Foix-Chavany-Marie syndrome (FCMS) is a distinct clinical picture of suprabulbar (pseudobulbar) palsy due to bilateral anterior opercular lesions. Symptoms include anarthria/severe dysarthria and loss of voluntary muscular functions of the face and tongue, and problems with mastication and swallowing with preservation...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章,评审

    doi:10.1017/s0012162200000232

    authors: Christen HJ,Hanefeld F,Kruse E,Imhäuser S,Ernst JP,Finkenstaedt M

    更新日期:2000-02-01 00:00:00

  • Social cognition in children with epilepsy in mainstream education.

    abstract:AIM:To establish whether deficits in social cognition are present in children with generalized or focal epilepsy in mainstream education, and whether any relation exists between social cognition, communication, and behaviour measures. METHOD:In a cross-sectional study, children with an epilepsy-only diagnoses in mains...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/dmcn.12613

    authors: Lew AR,Lewis C,Lunn J,Tomlin P,Basu H,Roach J,Rakshi K,Martland T

    更新日期:2015-01-01 00:00:00

  • Anencephalus in the Oxford Record Linkage Study area.

    abstract::The incidence of anencephalus in the largely rural areas of Oxfordshire and west Berkshire from 1965 to 1972 was ascertained from the files of the Oxford Record Linkage Study as 1-49 per 1000 total births. There was little variation within the area, but there was a marked increase in incidence over the eight years of ...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1976.tb04210.x

    authors: Fedrick J

    更新日期:1976-10-01 00:00:00

  • Respiratory and sleep disorders in female children with atypical Rett syndrome caused by mutations in the CDKL5 gene.

    abstract:AIM:In female children with drug-resistant seizures and developmental delay from birth, atypical Rett syndrome caused by mutations in the CDKL5 gene should be considered. Several clinical features resemble classic Rett syndrome. Respiratory and sleep abnormalities are frequently present in Rett syndrome, whereas little...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.2012.04432.x

    authors: Hagebeuk EE,van den Bossche RA,de Weerd AW

    更新日期:2013-05-01 00:00:00

  • Short-latency somatosensory evoked potentials in infantile autism: evidence of hyperactivity in the right primary somatosensory area.

    abstract::Children with infantile autism sometimes show hyperesthesia or hypoesthesia to touch, pain, and/or temperature. To clarify the pathophysiology, we examined short-latency somatosensory evoked potentials (S-SEPs), elicited by median nerve stimulation, in 24 children with infantile autism (17 males, seven females; age ra...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1017/s0012162207000059.x

    authors: Miyazaki M,Fujii E,Saijo T,Mori K,Hashimoto T,Kagami S,Kuroda Y

    更新日期:2007-01-01 00:00:00

  • Relationship between lead exposure indicators and neuropsychological performance in children.

    abstract::This study surveyed 237 schoolchildren in a lead-polluted industrial area in northern Italy to assess the relationship between various biological indicators (lead in blood, hair and teeth, and delta-aminolevulinic dehydratase [ALA-D] activity) and some neuropsychological functions, assessed by a battery of five psycho...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1989.tb03977.x

    authors: Bergomi M,Borella P,Fantuzzi G,Vivoli G,Sturloni N,Cavazzuti G,Tampieri A,Tartoni PL

    更新日期:1989-04-01 00:00:00

  • Transient bilateral internuclear ophthalmoplegia after minor head-trauma.

    abstract::Following minor occipital head-trauma, a six-year-old boy developed bilateral internuclear ophthalmoplegia (INO) as the only neurological sign. After having excluded all other possible aetiological causes by careful examination, including magnetic resonance imaging, the symptoms eventually were attributed to the traum...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1993.tb11618.x

    authors: Mueller C,Koch S,Toifl K

    更新日期:1993-02-01 00:00:00

  • Physical impairment, disability and handicap in rural Nepal.

    abstract::Observations were made of people with physical impairments, disabilities and handicaps during a two-month journey in remote, mountainous areas of Nepal where traditional forms of village life have been maintained. Descriptions are given of the types and frequency of visible physical impairments and their distribution ...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1983.tb13839.x

    authors: Richardson SA

    更新日期:1983-12-01 00:00:00

  • Prevalence and risk factors for autism spectrum disorder in epilepsy: a systematic review and meta-analysis.

    abstract:AIM:To assess the prevalence and risk factors for autism spectrum disorder (ASD) in epilepsy, and to better understand the relationship and comorbidity between these disorders. METHOD:PsychINFO and PubMed were searched for articles published in the past 15 years that examined the prevalence of ASD in individuals with ...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/dmcn.13598

    authors: Strasser L,Downes M,Kung J,Cross JH,De Haan M

    更新日期:2018-01-01 00:00:00

  • Longitudinal study of growth and development of young Jamaican children recovering from severe protein-energy malnutrition.

    abstract::The developmental level and nutritional status of a group of 17 children aged between six and 24 months who were admitted to hospital with severe protein-energy malnutrition were studied from admission to hospital until 36 months after returning home. They were compared with a group of 14 adequately nourished children...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1982.tb13624.x

    authors: Grantham-McGregor SM,Powell C,Stewart M,Schofield WN

    更新日期:1982-06-01 00:00:00

  • Limb paralysis as a manifestation of Coxsackie B virus infection.

    abstract::Forty-four African children (25 girls, 19 boys) are described with single or multiple limb paralysis as a manifestation of infection with Coxsackie B virus. Single limb paralysis involved exclusively the lower extremity, with no nervous system involvement elsewhere and a relatively benign prognosis. Multiple limb para...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1991.tb14903.x

    authors: Yui LA,Gledhill RF

    更新日期:1991-05-01 00:00:00

  • Down's syndrome and the family: follow-up of children first seen in infancy.

    abstract::Twenty-three survivors of a prospective study of infants with Down's syndrome were followed up at eight or nine years of age. All but three lived at home, and those three came home for weekends or school holidays. IQs varied from less than 20 to 80 (mean 48). IQ and adaptive behaviour scores were related to birthweigh...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1984.tb04478.x

    authors: Gath A,Gumley D

    更新日期:1984-08-01 00:00:00

  • The impact on socio-emotional development and quality of life of language impairment in 8-year-old children.

    abstract:AIM:To estimate the impact of different types of language disorders on socio-emotional development and health-related quality of life (HRQOL) in 8-year-old children. METHOD:In a prospective cohort including 13 427 newborns, of 10 911 eligible children (66 excluded because of intellectual disability or foreign language...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.2010.03794.x

    authors: Van Agt H,Verhoeven L,Van Den Brink G,De Koning H

    更新日期:2011-01-01 00:00:00

  • Monozygotic boys with fragile X syndrome.

    abstract::Monozygotic twin boys with fragile X syndrome underwent thorough genetic, psychiatric, neurological, and language evaluations at 10 years of age. They both demonstrated physical features, speech and language difficulties, social problems, and attentional deficits that characterize the behavioural phenotype of fragile ...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1017/s0012162200001420

    authors: Sheldon L,Turk J

    更新日期:2000-11-01 00:00:00

  • Qualitative changes in dynamic tripod grip between seven and 14 years of age.

    abstract::The dynamic tripod grip during handwriting was examined among seven- to 14-year-old children. Four components were measured: (a) degree of index-finger flexion; (b) degree of forearm pronation/supination; (c) number of fingers used on the pencil shaft; and (d) thumb and forefinger opposition. Developmental trends were...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1983.tb13846.x

    authors: Ziviani J

    更新日期:1983-12-01 00:00:00

  • Optimal clinical management of children receiving ketogenic parenteral nutrition: a clinical practice guide.

    abstract:AIM:To give evidence-based recommendations on the application of ketogenic diet parenteral nutrition (KD-PN) in emergency situations. METHOD:An international group of experts (n=14) researched the literature and distributed a survey among 150 expert centers. International accepted guidelines (European Society for Clin...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/dmcn.14306

    authors: van der Louw E,Aldaz V,Harvey J,Roan M,van den Hurk D,Cross JH,Auvin S,Review Group.

    更新日期:2020-01-01 00:00:00

  • Mechanisms of disease and clinical features of mutations of the gene for mitofusin 2: an important cause of hereditary peripheral neuropathy with striking clinical variability in children and adults.

    abstract::Mitofusin 2, a large transmembrane GTPase located in the outer mitochondrial membrane, promotes membrane fusion and is involved in the maintenance of the morphology of axonal mitochondria. Mutations of the gene encoding mitofusin 2 (MFN2) have recently been identified as the cause of approximately one-third of dominan...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1469-8749.2010.03613.x

    authors: Ouvrier R,Grew S

    更新日期:2010-04-01 00:00:00

  • Extra-articular subtalar arthrodesis with cancellous bone graft and internal fixation for children with myelomeningocele.

    abstract::Extra-articular subtalar arthrodesis with cancellous bone graft and internal fixation was performed on 20 feet of 12 children with myelomeningocele, whose average age at operation was 7.4 years. Indication for surgery was progressive hindfoot valgus deformity causing difficulty in fitting orthoses. At average follow-u...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1991.tb05112.x

    authors: Aronson DD,Middleton DL

    更新日期:1991-03-01 00:00:00

  • The general movement optimality score: a detailed assessment of general movements during preterm and term age.

    abstract:AIM:To explore the appropriateness of applying a detailed assessment of general movements and characterize the relationship between global and detailed assessment. METHOD:The analysis was based on 783 video recordings of 233 infants (154 males, 79 females) who had been videoed from 27 to 45 weeks postmenstrual age. Ap...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/dmcn.12923

    authors: Einspieler C,Marschik PB,Pansy J,Scheuchenegger A,Krieber M,Yang H,Kornacka MK,Rowinska E,Soloveichick M,Bos AF

    更新日期:2016-04-01 00:00:00

  • The neurodevelopmental spectrum of congenital Zika infection: a scoping review.

    abstract:AIM:To describe the standardized neurodevelopmental outcomes after the first year of life in children with congenital Zika syndrome (CZS) and those exposed to Zika virus (ZIKV) during fetal life, but without microcephaly at birth. METHOD:This scoping review included observational studies about the standardized neurode...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/dmcn.14675

    authors: Carvalho A,Sales HF,Ventura P,Gnoatto-Medeiros M,Brites C,Lucena R

    更新日期:2020-12-01 00:00:00

  • MRI findings in patients with spastic cerebral palsy. II: Correlation with type of cerebral palsy.

    abstract::The authors studied MR images of the brain in 152 patients, aged 1 to 19 years (mean 3.3), who had spastic cerebral palsy (CP) and were attending two hospitals in Japan in 1993 and 1994. Eighty-one patients had diplegia, 45 had quadriplegia, and 26 had hemiplegia. Of patients with diplegia, 72 had periventricular leuk...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:

    authors: Okumura A,Kato T,Kuno K,Hayakawa F,Watanabe K

    更新日期:1997-06-01 00:00:00

  • The reliability and validity of a research-grade pedometer for children and adolescents with cerebral palsy.

    abstract:AIM:The aim of this study was to determine the reliability, validity, and optimal placement of pedometers in children with cerebral palsy (CP) who ambulate without aids. METHOD:Seventeen participants aged 7 to 17 years with CP (eight males, nine females; mean age 12y 4mo; SD 3y 2mo), who could ambulate without aids, w...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/dmcn.12181

    authors: Maher C,Kenyon A,McEvoy M,Sprod J

    更新日期:2013-09-01 00:00:00

  • Neurodevelopmental screening at five years of children who were at risk neonatally.

    abstract::A neurodevelopmental screening test with cumulative scoring for abnormal test responses was performed on 845 five-year-old Finnish children who, in the newborn period, had had disorders which placed them in a high-risk group, and on 70 controls. The results showed a significant difference between the neurodevelopmenta...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1981.tb02015.x

    authors: Michelsson K,Ylinen A,Donner M

    更新日期:1981-08-01 00:00:00

  • The prediction of long-term functional outcomes of children with cerebral palsy.

    abstract::Current information was obtained from 117 respondents, including 71 who completed interviews, of a population of 810 individuals who had been diagnosed with cerebral palsy between 1951 and 1974. Original chart reviews constituted the basis for predicting employment capabilities of the interviewed cohort. A comparison ...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1995.tb11954.x

    authors: O'Grady RS,Crain LS,Kohn J

    更新日期:1995-11-01 00:00:00

  • Victimization and restricted participation among young people with disabilities in the US child welfare system.

    abstract:AIM:The aim of this study was to assess the role of disability and victimization in young people's participation in developmentally salient activities by analyzing a nationally representative group of young people from the child welfare system (CWS). METHOD:Data were obtained from interviews with young people and thei...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/dmcn.12678

    authors: Berg KL,Shiu CS,Msall ME,Acharya K

    更新日期:2015-06-01 00:00:00