Neural tube defects: maternal serum screening and prenatal diagnosis.

Abstract:

:Neural tube defects represent some of the most common and serious of the congenital malformations. Although elevation of alpha-fetoprotein in amniotic fluid is not diagnostic, it does indicate an abnormality of the fetus in a very high proportion of cases. A normal level, however, does not exclude the possibility of a closed neural tube defect. It is therefore recommended that all amniocenteses performed between 15 and 20 weeks of gestation include measurement of alpha-fetoprotein. Maternal serum alpha-fetoprotein assay is a screening test and pilot studies will be necessary to determine its value as a routine prenatal blood test.

journal_name

Pediatr Clin North Am

authors

Crandall BF,Lebherz TB,Freihube R

doi

10.1016/s0031-3955(16)33607-0

subject

Has Abstract

pub_date

1978-08-01 00:00:00

pages

619-29

issue

3

eissn

0031-3955

issn

1557-8240

pii

S0031-3955(16)33607-0

journal_volume

25

pub_type

杂志文章
  • Overcoming childhood asthma disparities of the inner-city poor.

    abstract::Asthmatic children living in low-income families in United States inner city communities continue to have disproportionately high rates of hospitalizations, emergency department visits, disability, and death. Current research implicates a combination of environmental, biologic, and disease mismanagement factors that u...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0031-3955(03)00045-2

    authors: Federico MJ,Liu AH

    更新日期:2003-06-01 00:00:00

  • Twenty Questions (and Answers) About Media Violence and Cyberbullying.

    abstract::For decades, pediatricians have been concerned about the impact of media on the health and well-being of children and adolescents. Robust research has found an association between exposure to media violence and real-life aggression in children and teens. Other effects include desensitization, fear, and attitudes that ...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcl.2019.12.002

    authors: Hogan M,Strasburger V

    更新日期:2020-04-01 00:00:00

  • Advances in monitoring and management of shock.

    abstract::Early recognition and treatment of pediatric shock, regardless of cause, decreases mortality and improves outcome. In addition to the conventional parameters (eg, heart rate, systolic blood pressure, urine output, and central venous pressure), biomarkers and noninvasive methods of measuring cardiac output are availabl...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcl.2013.02.013

    authors: Mtaweh H,Trakas EV,Su E,Carcillo JA,Aneja RK

    更新日期:2013-06-01 00:00:00

  • Pediatric Quality Improvement: Practical and Scholarly Considerations.

    abstract::This article describes important aspects of health-care quality, quality improvement (QI), patient safety (PS), and approaches to research on QI/PS efforts. Common terminology to facilitate an understanding of QI and PS research is reviewed. Models for understanding system and process performance are discussed. Introd...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcl.2015.12.006

    authors: Niedner MF

    更新日期:2016-04-01 00:00:00

  • Syncope in the pediatric patient. The cardiologist's perspective.

    abstract::The evaluation of syncopal children or adolescents relies heavily on a thorough, detailed history and physical examination. All syncope associated with exercise or exertion must be considered dangerous. The ECG is mandatory, but other laboratory tests are generally of limited value unless guided by pertinent positives...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0031-3955(05)70113-9

    authors: Lewis DA,Dhala A

    更新日期:1999-04-01 00:00:00

  • The Approach to the Child with Joint Complaints.

    abstract::This article focuses on creating an orderly approach to history taking, examination, and ordering appropriate investigations when caring for a child with joint complaints. It classifies complaints as those with and without pain, swelling, or fever and of short or long duration. It recommends an approach to the physica...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcl.2018.03.003

    authors: Haines KA

    更新日期:2018-08-01 00:00:00

  • Cysticercosis. A modern day plague.

    abstract::The authors describe the magnitude of the cysticercosis problem and describe the organism, the clinical features of the disease, the propensity of the organism for development in the central nervous system, pathologic considerations, clinical diagnosis, and treatment. ...

    journal_title:Pediatric clinics of North America

    pub_type: 临床试验,杂志文章,评审

    doi:10.1016/s0031-3955(16)34864-7

    authors: Brown WJ,Voge M

    更新日期:1985-08-01 00:00:00

  • What's new in transfusion medicine?

    abstract::The safety of the blood supply has increased tremendously in the past decade. Donor screening and improved infectious disease testing of units for transfusion have contributed to the decreased risk of transfusion-transmitted diseases. Reduction of the number of passenger leukocytes from RBC and platelet transfusions d...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0031-3955(05)70433-8

    authors: Manno CS

    更新日期:1996-06-01 00:00:00

  • Childhood brain tumors: current status of clinical trials in newly diagnosed and recurrent disease.

    abstract::Primary childhood brain tumors are the second most common form of childhood cancer. Though progress in this area has been slow, the field has evolved considerably over the past 10 years. This article focuses on new information that will influence our treatment of the more common pediatric brain tumors. ...

    journal_title:Pediatric clinics of North America

    pub_type: 临床试验,杂志文章,评审

    doi:10.1016/s0031-3955(16)34829-5

    authors: Allen JC

    更新日期:1985-06-01 00:00:00

  • Sudden death in sports.

    abstract::I have stressed the known medical and environmental factors associated with unexpected, sudden death in sports in children, and I have recommended restrictions or environmental alterations to prevent sudden death associated with an individual sport. Medical problems such as cardiomyopathies, posterior mitral valve lea...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章

    doi:10.1016/s0031-3955(16)34285-7

    authors: Luckstead EF

    更新日期:1982-12-01 00:00:00

  • Short bowel syndrome in infants and children.

    abstract::This article defines short bowel syndrome and reviews the pathophysiology, medical management, and surgical manipulations proposed to improve intestinal absorption. Emphasis is also placed on possible future methods of management. ...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0031-3955(16)34904-5

    authors: Schwartz MZ,Maeda K

    更新日期:1985-10-01 00:00:00

  • Routine procedures for examination of stool and blood for parasites.

    abstract::The diagnosis of a parasitic infection depends upon demonstration of the organism in stool, blood, or tissue specimens, and a variety of relatively simple procedures is available for this purpose. In this article, the author describes those procedures that are most frequently used on a routine basis. ...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章

    doi:10.1016/s0031-3955(16)34868-4

    authors: Carroll MJ

    更新日期:1985-08-01 00:00:00

  • Minimal, progressive, and fluctuating hearing losses in children. Characteristics, identification, and management.

    abstract::Referring to specific types of hearing loss as "minimal" or "mild" seems to imply that their effects are equally mild or negligible. A growing body of literature, however, supports the notion that such losses can have a significant impact on the communicative and educational development of young children. Although OME...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0031-3955(05)70081-x

    authors: Tharpe AM,Bess FH

    更新日期:1999-02-01 00:00:00

  • Chronic cough in children.

    abstract::The management of chronic cough, a common complaint in children, is challenging for most health care professionals. Millions of dollars are spent every year on unnecessary testing and treatment. A rational approach based on a detailed interview and a thorough physical examination guides further intervention and manage...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcl.2013.04.004

    authors: Wagner JB,Pine HS

    更新日期:2013-08-01 00:00:00

  • Molecular and cellular basis of congenital heart disease.

    abstract::The cellular and molecular basis of congenital heart disease (CHD) is an evolving area of rapid discovery. This article introduced the basic mechanisms underlying cardiac development and CHD in order to permit a clear understanding of current diagnostics and therapeutics and their future development. It is clear that ...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcl.2006.08.010

    authors: Sander TL,Klinkner DB,Tomita-Mitchell A,Mitchell ME

    更新日期:2006-10-01 00:00:00

  • Recognizing the impact of marital discord and parental depression on children. A family-centered approach.

    abstract::The American family is changing. Pediatricians are increasingly aware of treating children within a family systems context. Patients present with a variety of biopsychosocial problems, and pediatrics must continue to adjust to fit the changing needs of children and their families. Pediatricians must view themselves as...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0031-3955(16)38916-7

    authors: Richman JM,Chapman MV,Bowen GL

    更新日期:1995-02-01 00:00:00

  • The development of normal feeding and swallowing.

    abstract::The development of feeding skills is an extremely complex process influenced by multiple anatomic, neurophysiologic, environmental, social, and cultural factors. Most children negotiate the necessary developmental sequence without significant difficulties. An understanding of the development of normal feeding abilitie...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0031-3955(16)38229-3

    authors: Stevenson RD,Allaire JH

    更新日期:1991-12-01 00:00:00

  • Social skills training for children with autism.

    abstract::This article summarizes the current literature on social skills training for children and adolescents with autism spectrum disorders. The article describes several different methods of social skills training, along with a summary of research findings on effectiveness. Interventions described include social skills grou...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcl.2011.10.001

    authors: Bohlander AJ,Orlich F,Varley CK

    更新日期:2012-02-01 00:00:00

  • The sleepy child.

    abstract::Disorders of excessive sleepiness are uncommon in children. When they occur, the presentation is often consistent with the developmental age of the child and does not meet either historical or laboratory criteria determined with adults in mind. Because of these differences, the true diagnosis can be missed or inadequa...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0031-3955(03)00175-5

    authors: Givan DC

    更新日期:2004-02-01 00:00:00

  • Update on perinatal HIV transmission.

    abstract::Over the past decade, much progress has been made in understanding the risk factors and timing of perinatal HIV transmission. Even more impressive have been the successful clinical trials with antiretrovirals, such as ZDV, ZDV-3TC, and nevirapine, that demonstrated significant reductions in the risk for infant infecti...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0031-3955(05)70193-0

    authors: Fowler MG,Simonds RJ,Roongpisuthipong A

    更新日期:2000-02-01 00:00:00

  • Prevention of HIV infection in children.

    abstract::The threshold of a new century is an opportune time to review advances in the prevention of HIV infection in children. In the United States, progress in the ability to virtually eliminate perinatal HIV transmission that was unthinkable just a few years ago has been achieved. Clinicians providing care to pregnant women...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0031-3955(05)70203-0

    authors: Bulterys M,Fowler MG

    更新日期:2000-02-01 00:00:00

  • Medical and orthopedic conditions and sports participation.

    abstract::The presence of certain medical or orthopedic conditions need not preclude adolescents from being physically active and participating in sports. The benefits of continued physical activity far outweigh any concerns for potential complications for most such conditions. This article reviews sport participation guideline...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章

    doi:10.1016/j.pcl.2010.03.005

    authors: Diokno E,Rowe D

    更新日期:2010-06-01 00:00:00

  • Nutritional regulation of host resistance and predictive value of immunologic tests in assessment of outcome.

    abstract::In this review, the authors describe the current information on nutrition modulation of immunity, enumerate the various immunologic tests that are potentially useful in nutritional assessment, examine the reliability of tests predicting disease and complications, and discuss how immunologic evaluation may help in the ...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0031-3955(16)34800-3

    authors: Puri S,Chandra RK

    更新日期:1985-04-01 00:00:00

  • Chronic musculoskeletal pain in young athletes.

    abstract::Chronic musculoskeletal pain is becoming increasingly common in young athletes. When these athletes do not respond well to standard treatments, for example physical theraphy and anti-inflammatories, other diagnoses must be considered, such as reflex sympathetic dystrophy, fibromyalgia, and/or overtraining syndrome. ...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0031-3955(02)00008-1

    authors: Small E

    更新日期:2002-06-01 00:00:00

  • Herbs to homeopathy-medicinal products for children.

    abstract::Many pediatric patients and their families use dietary supplements and homeopathy. They do not always disclose this information to their health care practitioners. It is important that health care practitioners are aware of the research available in these areas and discuss the use of these products openly with their p...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcl.2007.10.005

    authors: Gardiner P,Riley DS

    更新日期:2007-12-01 00:00:00

  • Medical emergency and rapid response teams.

    abstract::Hospitals that care for children are establishing medical emergency or rapid response teams as system solutions for preventing unexpected but foreseeable respiratory and cardiac arrest on inpatient units. Typically, an experienced team of doctors and nurses responds quickly to a direct request by any level of staff or...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcl.2008.04.006

    authors: Tibballs J,van der Jagt EW

    更新日期:2008-08-01 00:00:00

  • Psychopharmacology of autistic spectrum disorders in children and adolescents.

    abstract::This article provides an overview of the psychopharmacologic management of irritability, hyperactivity, and repetitive behaviors in children and adolescents with autism spectrum disorder. A review of the current literature on medications used to treat these conditions with emphasis on randomized controlled trials is p...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcl.2010.10.011

    authors: Nazeer A

    更新日期:2011-02-01 00:00:00

  • Disorders of the hair and scalp in children.

    abstract::A wide variety of disorders involving the scalp and hair exist that may be encountered in the pediatric and adolescent population. An approach to the differential diagnosis of many of these conditions can be considered once the patient is found to have either alopecia, scaling, or tumors of the scalp. Certainly other ...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0031-3955(16)38159-7

    authors: Levy ML

    更新日期:1991-08-01 00:00:00

  • Spinal deformity.

    abstract::Spinal deformity is a relatively common disorder, particularly in teenage girls. Early detection is possible by a simple, quick visual inspection that should be a standard part of the routine examination of all preteen and teenage patients. Follow-up observation will reveal those curvatures that are progressive and pe...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章

    doi:10.1016/s0031-3955(16)36155-7

    authors: Bunnell WP

    更新日期:1986-12-01 00:00:00

  • Malignant abdominal masses in children: quick guide to evaluation and diagnosis.

    abstract::A palpable mass in the abdomen of a child is a serious finding. In this article the authors present their single-institution experience of how these malignancies present and their distribution by age and diagnosis. The most common abdominal malignancies diagnosed in the pediatric population include neuroblastoma, Wilm...

    journal_title:Pediatric clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0031-3955(02)00098-6

    authors: Golden CB,Feusner JH

    更新日期:2002-12-01 00:00:00