Abstract:
PURPOSE:To assess application of cystatin C and neutrophil gelatinase-associated lipocalin (NGAL) as biomarkers for renal ischemic injury. We also evaluated the use of allopurinol as a renoprotective agent. A second goal was to assess cystatin C as a biomarker in patients undergoing partial nephrectomy. METHODS:Using 58 Sprague-Dawley rats, we evaluated urinary cystatin C (n=26) and NGAL (n=32) as a biomarker for renal ischemia injury. Half of the rats were pretreated with allopurinol; the other cohort served as a control. The right renal hilum was ligated in all rats, thereby creating a solitary kidney model. After a 30-minute stabilization period, the left hilum was clamped for time periods of 15, 30, and 60 minutes. Urinary levels of cystatin C and NGAL were then measured at the following time points: Preclamp (after the 30-minute stabilization period) and postclamp (30, 45, and 60 minute periods after unclamping). For our clinical subjects, serum cystatin C levels (n=17) were obtained preoperatively, at the induction of anesthesia before robot-assisted partial nephrectomy, immediately postoperatively, and on postoperative days 1 and 2. Three of these patients had their tumors excised off clamp and served as controls. We then estimated glomerular filtration rate by using the Creatinine-Cystatin C Equation. RESULTS:Urinary levels of cystatin C and NGAL increased after renal clamping. The 30-minute period of ischemia demonstrated the greatest increase of these biomarkers. Allopurinol did appear to serve a renoprotective function in those animals undergoing 30-minute clamp times. In our clinical patients, the serum cystatin C levels did increase at each postoperative time point, but remained nonelevated in the control group. CONCLUSIONS:Cystatin C and NGAL both appear to be useful biomarkers of renal injury. Studies with larger numbers are needed, however. Also, allopurinol does exhibit renoprotective effects against ischemic injury.
journal_name
J Endouroljournal_title
Journal of endourologyauthors
Woodson BW,Wang L,Mandava S,Lee BRdoi
10.1089/end.2013.0198subject
Has Abstractpub_date
2013-12-01 00:00:00pages
1510-5issue
12eissn
0892-7790issn
1557-900Xjournal_volume
27pub_type
杂志文章abstract:PURPOSE:To determine the feasibility of bladder cryoablation (BC) applied laparoscopically, percutaneously, and transurethrally in a porcine survival study. The expected and observed area of cell death after BC was also examined. MATERIALS AND METHODS:Nine pigs were divided equally into the three treatment groups. Cry...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2008.0200
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:To assess whether our ureteroscopic real-time navigation system has the possibility to reduce radiation exposure and improve performance of ureteroscopic maneuvers in surgeons of various ages and experience levels. MATERIALS AND METHODS:Our novel ureteroscopic navigation system used a magnetic tracking device ...
journal_title:Journal of endourology
pub_type: 杂志文章,多中心研究
doi:10.1089/end.2015.0054
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVES:To determine and compare the status of urologic laparoscopic and robot-assisted surgery (RAS) across the world. METHODS:Two hundred ninety-one surveys were completed by urologists at various national and international conferences in 2008. The 58-item questionnaire assessed the individual and institutional p...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2010.0024
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Benign prostatic hyperplasia (BPH) affects more than 50% of men by the age of 60 and 90% by age 85. Many of these men are not candidates for surgical procedures such as transurethral resection of the prostate (TURP), stimulating the development of less-invasive forms of therapy. We studied the ut...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2005.19.159
更新日期:2005-03-01 00:00:00
abstract::Seminal vesicle cysts associated with other genitourologic abnormalities are rare. We describe the first known robot-assisted excision of a cystic seminal vesicle associated with ipsilateral renal agenesis in a symptomatic pediatric patient. The patient was discharged home on postoperative day 1 and remains symptom fr...
journal_title:Journal of endourology
pub_type: 杂志文章,评审
doi:10.1089/end.2006.0279
更新日期:2007-07-01 00:00:00
abstract::In five patients with chronic intractable ureteral obstruction, a fine-bore nephrostomy tube was placed in a subcutaneous tunnel to drain the kidney without an external appliance. Good quality of life was achieved for 6 months to 2 years. When conventional intraluminal stents cannot be used, consideration should be gi...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.1997.11.411
更新日期:1997-12-01 00:00:00
abstract:PURPOSE:To assess whether intravenous magnesium sulfate infusion affects analgesic requirements during monitored anesthesia care (MAC) for shockwave lithotripsy (SWL). PATIENTS AND METHODS:Fifty patients in ASA class I or II undergoing SWL with MAC were randomized into two groups. Induction of MAC was produced by bolu...
journal_title:Journal of endourology
pub_type: 杂志文章,随机对照试验
doi:10.1089/end.2006.0195
更新日期:2007-02-01 00:00:00
abstract:INTRODUCTION:The current experimental study aimed at evaluating the temperature raise of the irrigation fluid caused by the use of the thulium (Tm:YAG) and holmium laser (Ho:YAG) in the upper urinary tract (UT) of pigs. MATERIALS AND METHODS:An experimental setting was designed for the investigation of differences in ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2015.0768
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:Excessive bulking force during ureteral access sheath (UAS) placement may induce injury. The sliding friction between surfaces can be reduced with the application of ultrasonic vibration. We investigated the efficacy and safety of an ultrasonic vibration transducing device for reducing the maximal ureteral acce...
journal_title:Journal of endourology
pub_type: 杂志文章,随机对照试验
doi:10.1089/end.2018.0772
更新日期:2019-02-01 00:00:00
abstract::Severe urethral stricture disease as an isolated entity can be a management dilemma. In the patient described here, this problem was associated with prior external-beam radiation and cryosurgical ablation of the prostate, and a functional artificial urethral sphincter (AUS) had been placed. An attempt to relieve parti...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.1999.13.585
更新日期:1999-10-01 00:00:00
abstract::Ureteral stents find wide application in urology. The majority of patients with indwelling ureteral stents are at an increased risk of urinary tract infection. Stent encrustation and its associated complications lead to significant morbidity. This review critically evaluates various polymers that find their applicatio...
journal_title:Journal of endourology
pub_type: 历史文章,杂志文章,评审
doi:10.1089/end.2009.0516
更新日期:2010-02-01 00:00:00
abstract::It seems likely, and indeed inevitable, that medical device usage will continue its rapid increase over the next 10 to 20 years and beyond. For surgeons, these new inventions will come in many forms but should take into account biocompatibility and resistance to encrustations and to microorganisms. This review focuses...
journal_title:Journal of endourology
pub_type: 杂志文章,评审
doi:10.1089/end.1999.13.1
更新日期:1999-02-01 00:00:00
abstract:PURPOSE:To report our experience with en bloc stapling of the renal hilum during laparoscopic nephrectomy (LN) and nephroureterectomy and to compare it with separate stapling performed during the same period at the same institution. PATIENTS AND METHODS:We conducted a retrospective review of 125 laparoscopic nephrecto...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2008.0528
更新日期:2009-04-01 00:00:00
abstract:PURPOSE:The correct length of a ureteral stent is important in minimizing postplacement discomfort and stent migration. We describe and validate a method to accurately measure the ureteral length. MATERIALS AND METHODS:The ureteral length in 48 patients undergoing ureteral stent placement for urolithiasis was measured...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2013.0041
更新日期:2013-08-01 00:00:00
abstract:: Aims: To compare outcomes of monopolar vs bipolar transurethral resection of the prostate (TURP) in the management of exclusively moderate-large volume prostatic hyperplasia in terms of maximum flow rate as a surrogate for clinical efficacy, duration of catheterization, ho...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2020.0840
更新日期:2020-12-28 00:00:00
abstract::Ureteral obstruction secondary to extrinsic compression is uncommon. Extrinsic compression results from both benign and malignant conditions of the retroperitoneum. In certain patients, laparoscopic ureterolysis is a minimally invasive alternative to the open approach. To date, the largest numbers of patients have und...
journal_title:Journal of endourology
pub_type: 杂志文章,评审
doi:10.1089/end.2005.19.710
更新日期:2005-07-01 00:00:00
abstract::We report an unusual ureteral foreign body resulting from a complication of pulsed-dye laser lithotripsy: a retained laser fiber fragment. It was removed with two endoscopic procedures without long-term problems. ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.1994.8.29
更新日期:1994-02-01 00:00:00
abstract:PURPOSE:The purpose of this study was to measure the accuracy of stone-specific algorithms (S-mode) and the posterior acoustic shadow for determining kidney stone size with ultrasound (US) in vivo. MATERIALS AND METHODS:Thirty-four subjects with 115 renal stones were prospectively recruited and scanned with S-mode on ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2016.0341
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Biodegradable urethral stents have been used clinically for some years mainly in order to prevent postoperative urinary retention after minimally invasive thermotreatment of benign prostatic hyperplasia. We previously reported a 15-month-follow-up pilot study of a bioabsorbable self-expandable, s...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/08927790260472926
更新日期:2002-12-01 00:00:00
abstract::Laparoscopy has become the essential surgical approach to the adrenal gland at many institutions, including ours. At the Cleveland Clinic, laparoscopic adrenalectomy for benign and malignant adrenal neoplasms can be performed by either the transperitoneal or the retroperitoneal approach. Herein, we present our techniq...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/089277901750299302
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVES:To evaluate the ex vivo accuracy of an MRI-TRUS fusion device for guiding targeted prostate biopsies, to identify the origin of errors, and to evaluate the likelihood that lesions can be accurately targeted. MATERIALS AND METHODS:Three prostate phantoms were used to perform 27 biopsies using transperineal M...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2015.0864
更新日期:2016-06-01 00:00:00
abstract:: Objective: Kidney stone formers are at risk for opioid dependence. The aim of this study is to describe opiate exposure and determine predictors of prolonged opiate use among kidney stone formers after surgery. Materials and Methods: ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2018.0796
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:To compare the morbidity of percutaneous nephrolithotomy (PCNL) requiring multiple percutaneous tracts with that of procedures requiring a single tract for calculus clearance. PATIENTS AND METHODS:Data from 20 patients undergoing PCNL through two or more percutaneous renal tracts over a 1-year period were comp...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2006.20.753
更新日期:2006-10-01 00:00:00
abstract:INTRODUCTION:Semirigid and flexible ureterorenoscopy (URS) procedures are safe and efficient treatment options for urolithiasis of all localizations. Sometimes, a Double-J stent is placed in preparation of definitive treatment. The aim of our study was to evaluate the influence of prestenting on the outcome of URS. PA...
journal_title:Journal of endourology
pub_type: 杂志文章,多中心研究
doi:10.1089/end.2015.0109
更新日期:2016-03-01 00:00:00
abstract:: Objective: The aim of this study was to introduce the "ultrathin parenchyma" resection in a robot-assisted partial nephrectomy (RAPN) via the retroperitoneal approach, and to assess the feasibility, security, and effectiveness of this technique. Me...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2019.0698
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:To compare blind access and totally tubeless percutaneous antegrade removal and pneumatic transurethral ureterolithotripsy for the management of impacted upper-ureteral calculi >1 cm. PATIENTS AND METHODS:Seventy patients (41 male, 29 female) with impacted upper-ureteral calculi >1 cm were selected in randomiz...
journal_title:Journal of endourology
pub_type: 杂志文章,随机对照试验
doi:10.1089/end.2006.20.616
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although ultrasonography-guided percutaneous nephrostomy is relatively safe, a number of factors make it challenging for inexperienced operators. A computerized needle navigation technique using tracked ultrasonography snapshots was investigated to determine whether performance of percutaneous ne...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2014.0011
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:To report the outcomes of patients with ureteroenteric strictures after ileal conduit urinary diversion that were managed with Resonance metallic ureteral stents. PATIENTS AND METHODS:Ten ureteroenteric strictures in patients with ileal conduits that were managed with metallic ureteral stenting were retrospect...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2008.0454
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Bacterial colonization of indwelling ureteral stents may serve as a nidus for bacteriuria in operations where stents are manipulated. The predictive value of urine cultures in the assessment of stent colonization was examined in 65 patients with indwelling ureteral stents. PATIENTS AND METHODS:P...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.1999.13.735
更新日期:1999-12-01 00:00:00
abstract::The preliminary experience with 64 patients who have undergone HoLEP combined with intravesical morcellation is presented. The mean preoperative prostate volume was 75.3 cc. The mean laser time was 46.9 minutes and the morcellator time a further 10.5 minutes. A mean total of 35.5 g of tissue was obtained, and 93% of t...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.1998.12.457
更新日期:1998-10-01 00:00:00