Abstract:
:A novel floating controlled-release drug delivery system was formulated in an effort increase the gastric retention time of the dosage form and to control drug release. The buoyancy was attributed to air and oil entrapped in the agar gel network. A floating controlled-release 300-mg theophylline tablet having a density of 0.67 was prepared and compared in vitro and in vivo to Theo-dur. The in vitro release rate of the floating tablet was slower. In vivo scintigraphic studies for a floating and a heavy nonfloating tablet, under fasting and nonfasting conditions, showed that the presence of food significantly increased the gastric retention time for both tablets, and tablet density did not appear to make a difference in the gastric retention time. However, the positions of the floating and nonfloating tablets in the stomach were very different. Bioavailability studies in human volunteers under both fasting and nonfasting conditions showed results comparable to those with Theo-dur. The floating controlled-release theophylline tablet maintained constant theophylline levels of about 2 mg/mL for 24 hr, which may be attributable to the release from the agar gel matrix and the buoyancy of the tablet in the stomach.
journal_name
Pharm Resjournal_title
Pharmaceutical researchauthors
Desai S,Bolton Sdoi
10.1023/a:1018921830385subject
Has Abstractpub_date
1993-09-01 00:00:00pages
1321-5issue
9eissn
0724-8741issn
1573-904Xjournal_volume
10pub_type
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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journal_title:Pharmaceutical research
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journal_title:Pharmaceutical research
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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journal_title:Pharmaceutical research
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journal_title:Pharmaceutical research
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更新日期:1995-12-01 00:00:00
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更新日期:1991-12-01 00:00:00
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更新日期:2009-08-01 00:00:00
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更新日期:2013-04-01 00:00:00
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journal_title:Pharmaceutical research
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更新日期:2018-02-21 00:00:00
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更新日期:2016-06-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:1995-12-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:1987-04-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:2001-06-01 00:00:00
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更新日期:2016-05-01 00:00:00
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journal_title:Pharmaceutical research
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更新日期:2010-09-01 00:00:00
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journal_title:Pharmaceutical research
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更新日期:2016-07-01 00:00:00