Abstract:
:Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that is pathologically characterized by inflammatory demyelination and neurodegeneration. Axonal damage, along with neuronal loss, occurs from disease onset and may lead to progressive and permanent disability. In contrast with the inflammatory pathways, the molecular mechanisms leading to MS neurodegeneration remain largely elusive. With improved understanding of these mechanisms, new potential therapeutic targets for neuroprotection have emerged. We review the current understanding of neurodegenerative processes at play in MS and discuss potential outcome measures and targets for neuroprotection trials.
journal_name
CNS Drugsjournal_title
CNS drugsauthors
Maghzi AH,Minagar A,Waubant Edoi
10.1007/s40263-013-0093-7subject
Has Abstractpub_date
2013-10-01 00:00:00pages
799-815issue
10eissn
1172-7047issn
1179-1934journal_volume
27pub_type
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