Theophylline-induced seizures in adults. Correlation with serum concentrations.

Abstract:

:Eight patients developed grand mal seizures during intravenous theophylline therapy. None had a history of neurologic disorder, and all were acutely ill with severe pulmonary or cardiovascular disease, or both. Serum theophylline concentrations obtained within 1 hour of the seizure ranged from 25 mug/ml to 70mug/ml, with a mean value (53 plus or minus 4.8 mug/ml) more than twice the upper limit of the recommended therapeutic concentration. This serum theophylline concentration was greater than the concentration found in a group of patients with less severe drug-related symptoms (35 plus or minus 1.8 mug/ml, P less than 0.01). A third group of patients without drug-related symptoms had a mean theophylline serum concentration of 19 plus or minus 2.0 mug/ml, which was less than that found in either group with toxicity symptoms (P less than 0.05). Factors predisposing to the high serum concentrations in the patients with seizures were both higher drug dosage, compared with the other groups (P less than 0.01), and hepatic dysfunction, which was more common in both groups with drug-related symptoms.

journal_name

Ann Intern Med

authors

Zwillich CW,Sutton FD,Neff TA,Cohn WM,Matthay RA,Weinberger MM

doi

10.7326/0003-4819-82-6-784

subject

Has Abstract

pub_date

1975-06-01 00:00:00

pages

784-7

issue

6

eissn

0003-4819

issn

1539-3704

journal_volume

82

pub_type

杂志文章
  • Effect of nasogastric tube size on gastroesophageal reflux and microaspiration in intubated patients.

    abstract:BACKGROUND:Little evidence exists to support the theory that small-bore nasogastric tubes prevent gastroesophageal reflux and microaspiration in intubated patients. OBJECTIVE:To determine whether gastroesophageal reflux and microaspiration in intubated patients can be reduced by the use of a small-bore nasogastric tub...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-130-12-199906150-00007

    authors: Ferrer M,Bauer TT,Torres A,Hernández C,Piera C

    更新日期:1999-06-15 00:00:00

  • Syndromes of Vibrio vulnificus infections. Clinical and epidemiologic features in Florida cases, 1981-1987.

    abstract:STUDY OBJECTIVE:To describe the clinical and epidemiologic features of Vibrio vulnificus infections. DESIGN:Case series based on notifiable disease report forms and patient medical records. SETTING:Cases reported to the Florida Department of Health and Rehabilitative Services from 1981 to 1987. PATIENTS:Sixty-two pa...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-109-4-318

    authors: Klontz KC,Lieb S,Schreiber M,Janowski HT,Baldy LM,Gunn RA

    更新日期:1988-08-15 00:00:00

  • A major focus of Legionnaires' disease in Bloomington, Indiana.

    abstract::Thirty-nine cases of Legionnaires' disease in a 16-month period were identified in visitors to and residents of Bloomington, Indiana. Thirty-five patients had spent at least one night at the Indiana Memorial Union in the 2 weeks before becoming ill. Five of 32 sporadic cases nationwide between 1 January and 31 March 1...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-90-4-587

    authors: Politi BD,Fraser DW,Mallison GF,Mohatt JV,Morris GK,Patton CM,Feeley JC,Telle RD,Bennett JV

    更新日期:1979-04-01 00:00:00

  • Physician practices in the prevention of venous thromboembolism.

    abstract:OBJECTIVE:To determine the rate of use of prophylaxis for venous thromboembolism in high-risk hospital patients. DESIGN:A retrospective medical record review. SETTING:A community-wide study in 16 short-stay hospitals in central Massachusetts. PATIENTS:A total of 2017 patients with multiple risk factors for venous th...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-591

    authors: Anderson FA Jr,Wheeler HB,Goldberg RJ,Hosmer DW,Forcier A,Patwardhan NA

    更新日期:1991-10-15 00:00:00

  • Chemoprevention of breast cancer: a summary of the evidence for the U.S. Preventive Services Task Force.

    abstract:PURPOSE:Chemoprevention offers promise as a strategy for reducing morbidity and mortality from breast cancer in women. This review examined the evidence for the effectiveness of chemoprevention in women without a history of breast cancer. DATA SOURCES:MEDLINE (1966 to December 2001). STUDY SELECTION:English-language,...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-137-1-200207020-00017

    authors: Kinsinger LS,Harris R,Woolf SH,Sox HC,Lohr KN

    更新日期:2002-07-02 00:00:00

  • A practice guideline revisited: screening for hypertension.

    abstract::In 1993, the Clinical Efficacy Assessment Subcommittee began evaluation of new topics and reevaluation of previous guidelines on common screening tests, which were published in Annals of Internal Medicine between 1988 and 1990 and republished as a collection in 1991 (Eddy DM, ed. Common Screening Tests. Philadelphia: ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-122-12-199506150-00008

    authors: Littenberg B

    更新日期:1995-06-15 00:00:00

  • Emerging magnetic resonance imaging technologies for musculoskeletal imaging under loading stress: scope of the literature.

    abstract::Imaging under loading stress is hypothesized to improve the diagnostic value of magnetic resonancel imaging (MRI) for musculoskeletal conditions. This article reviews 57 studies about MRI under physiologic loading stress performed in an upright or sitting position or under axial loading by using a compression device. ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-155-9-201111010-00009

    authors: Dahabreh IJ,Hadar N,Chung M

    更新日期:2011-11-01 00:00:00

  • Bacteremia caused by a previously unidentified species of rapidly growing Mycobacterium successfully treated with vancomycin.

    abstract::Bacteremia caused by rapidly growing mycobacteria are usually due to Mycobacterium fortuitum or M. chelonei. Other rapidly growing mycobacteria generally are considered to be nonpathogenic. We report the case of a patient with bacteremia due to an unidentified, rapidly growing, scotochromogenic mycobacteria that was d...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-99-4-475

    authors: Jadeja L,Bolivar R,Wallace RJ Jr,Silcox VA,Bodey GP

    更新日期:1983-10-01 00:00:00

  • Pneumocystis carinii pneumonia: a cluster of eleven cases.

    abstract::An unusual cluster of 11 patients with Pneumocystis carinii pneumonia occurred in a 3-month period at Memorial Hospital, New York. Ten of the 11 patients had lymphoma or leukemia. In 7 patients, corticosteroid therapy was decreased or stopped shortly before pneumocystis pneumonia was diagnosed. The pediatric patients ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-82-6-722

    authors: Singer C,Armstrong D,Rosen PP,Schottenfeld D

    更新日期:1975-06-01 00:00:00

  • Concepts of time in clinical research.

    abstract::The study of events in time is fundamental to biomedical research and public health surveillance. Clinicians have an intuitive appreciation for the relevance of time to health and disease, and patients invariably ask questions relating to time for which clinicians need answers. An appreciation of the picture of health...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-132-1-200001040-00007

    authors: Samet JM

    更新日期:2000-01-04 00:00:00

  • Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder: Synopsis of the Kidney Disease: Improving Global Outcomes 2017 Clinical Practice Guideline Update.

    abstract:Description:The Kidney Disease: Improving Global Outcomes (KDIGO) 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) is a selective update of the prior CKD-MBD guideline published in 2009. The guideline update an...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,实务指引

    doi:10.7326/M17-2640

    authors: Ketteler M,Block GA,Evenepoel P,Fukagawa M,Herzog CA,McCann L,Moe SM,Shroff R,Tonelli MA,Toussaint ND,Vervloet MG,Leonard MB

    更新日期:2018-03-20 00:00:00

  • Harms Reporting in Randomized Controlled Trials of Interventions Aimed at Modifying Microbiota: A Systematic Review.

    abstract:Background:Probiotics, prebiotics, and synbiotics are used increasingly, although the safety and potential harms of these interventions are poorly understood. Purpose:To examine how harms-related information is reported in publications of randomized controlled trials (RCTs) of probiotics, prebiotics, and synbiotics. ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M18-0343

    authors: Bafeta A,Koh M,Riveros C,Ravaud P

    更新日期:2018-08-21 00:00:00

  • The association of HIV susceptibility testing with survival among HIV-infected patients receiving antiretroviral therapy: a cohort study.

    abstract:BACKGROUND:HIV-1 genotypic and phenotypic susceptibility testing (GPT) optimizes antiretroviral selection, but its effect on survival is unknown. OBJECTIVE:To evaluate the association between GPT and survival. DESIGN:Cohort study. SETTING:10 U.S. HIV clinics. PATIENTS:2699 HIV-infected patients eligible for GPT (pl...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.7326/0003-4819-151-2-200907210-00003

    authors: Palella FJ Jr,Armon C,Buchacz K,Cole SR,Chmiel JS,Novak RM,Wood K,Moorman AC,Brooks JT,HOPS (HIV Outpatient Study) Investigators.

    更新日期:2009-07-21 00:00:00

  • The decision to biopsy, treat, or wait in suspected herpes encephalitis.

    abstract::The availability of vidarabine for the therapy of suspected herpes simplex encephalitis presents a difficult decision for a physician as to whether to do brain biopsy, to treat blindly, or to withhold specific therapy in a patient. The choice is made more difficult because the physician must weigh four likelihoods sim...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-92-5-641

    authors: Barza M,Pauker SG

    更新日期:1980-05-01 00:00:00

  • Professional organizations' position statements on physician-assisted suicide: a case for studied neutrality.

    abstract::Position statements opposing legalization of physician-assisted suicide by organizations such as the American College of Physicians-American Society of Internal Medicine rightly emphasize that palliative care should be the standard of care for the dying, and that the inadequacies that exist in its delivery should be r...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-138-3-200302040-00013

    authors: Quill TE,Cassel CK

    更新日期:2003-02-04 00:00:00

  • Sleep and sleep disorders in pregnancy.

    abstract::Sleep problems are common in pregnant women. This review examines sleep in normal pregnancy; discusses the physiologic bases for alterations in sleep, including hormonal and mechanical factors; and correlates these factors with changes in sleep of pregnant women, as determined subjectively by surveys and objectively b...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-134-5-200103060-00012

    authors: Santiago JR,Nolledo MS,Kinzler W,Santiago TV

    更新日期:2001-03-06 00:00:00

  • Prevention and control of type A influenza infections in nursing homes. Benefits and costs of four approaches using vaccination and amantadine.

    abstract::We developed a model to project morbidity, mortality, and costs attributable to type A influenza virus infections in nursing homes and to evaluate the relative benefits and costs of programs for prevention and control. Influenza vaccination was the most cost-effective intervention under various simulations in the mode...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-107-5-732

    authors: Patriarca PA,Arden NH,Koplan JP,Goodman RA

    更新日期:1987-11-01 00:00:00

  • Extended-duration venous thromboembolism prophylaxis in acutely ill medical patients with recently reduced mobility: a randomized trial.

    abstract:BACKGROUND:Extended-duration low-molecular-weight heparin has been shown to prevent venous thromboembolism (VTE) in high-risk surgical patients. OBJECTIVE:To evaluate the efficacy and safety of extended-duration enoxaparin thromboprophylaxis in acutely ill medical patients. DESIGN:Randomized, parallel, placebo-contro...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.7326/0003-4819-153-1-201007060-00004

    authors: Hull RD,Schellong SM,Tapson VF,Monreal M,Samama MM,Nicol P,Vicaut E,Turpie AG,Yusen RD,EXCLAIM (Extended Prophylaxis for Venous ThromboEmbolism in Acutely Ill Medical Patients With Prolonged Immobilization) study.

    更新日期:2010-07-06 00:00:00

  • Monovalent influenza A(H1N1) vaccine, 1986-1987. Recommendations of the Immunization Practices Advisory Committee. Centers for Disease Control, Department of Health and Human Services.

    abstract::These supplemental recommendations provide guidelines for a monovalent influenza A(H1N1) vaccine for protection against a newly emerged variant of influenza that has recently caused outbreaks among children and young adults in Asia. Guidance is provided for the use of this monovalent vaccine, which contains 15 microgr...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:1986-11-01 00:00:00

  • Prediction Models of Mortality in Acute Pancreatitis in Adults: A Systematic Review.

    abstract:Background:Acute pancreatitis (AP) varies in severity, prompting development of systems aimed at predicting prognosis to help guide therapy. Although several prediction approaches are available, their test characteristics and clinical utility are not completely understood. Purpose:To evaluate the test characteristics ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/M16-0650

    authors: Di MY,Liu H,Yang ZY,Bonis PA,Tang JL,Lau J

    更新日期:2016-10-04 00:00:00

  • Test performance of positron emission tomography and computed tomography for mediastinal staging in patients with non-small-cell lung cancer: a meta-analysis.

    abstract:PURPOSE:To compare the diagnostic accuracy of computed tomography (CT) and positron emission tomography (PET) with 18-fluorodeoxyglucose (FDG) for mediastinal staging in patients with non-small-cell lung cancer and to determine whether test results are conditionally dependent (the sensitivity and specificity of FDG-PET...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.7326/0003-4819-139-11-200311180-00013

    authors: Gould MK,Kuschner WG,Rydzak CE,Maclean CC,Demas AN,Shigemitsu H,Chan JK,Owens DK

    更新日期:2003-12-02 00:00:00

  • Contamination of intravenous infusion fluid: effects of changing administration sets.

    abstract::Daily change of intravenous (i.v.) infusion administration sets has been recommended by the Center for Disease Control since 1973 to reduce the risk of infusion bacteremia. To evaluate this recommendation, we undertook a prospective, randomized, controlled trial that compared the rates of i.v.-associated bacteremia, i...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-90-5-764

    authors: Buxton AE,Highsmith AK,Garner JS,West CM,Stamm WE,Dixon RE,McGowan JE Jr

    更新日期:1979-05-01 00:00:00

  • Strategies to identify the Lynch syndrome among patients with colorectal cancer: a cost-effectiveness analysis.

    abstract:BACKGROUND:Testing has been advocated for all persons with newly diagnosed colorectal cancer to identify families with the Lynch syndrome, an autosomal dominant cancer-predisposition syndrome that is a paradigm for personalized medicine. OBJECTIVE:To estimate the effectiveness and cost-effectiveness of strategies to i...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-155-2-201107190-00002

    authors: Ladabaum U,Wang G,Terdiman J,Blanco A,Kuppermann M,Boland CR,Ford J,Elkin E,Phillips KA

    更新日期:2011-07-19 00:00:00

  • Coronary angiography and angioplasty after acute myocardial infarction.

    abstract:PURPOSE:To assess the data that support the use of coronary angiography and angioplasty after acute myocardial infarction, that identify the risks of these procedures, and that analyze their use and costs. DATA SOURCES:English-language articles published between 1970 and June 1995 identified through a search of the ME...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-126-7-199704010-00007

    authors: Bates DW,Miller E,Bernstein SJ,Hauptman PJ,Leape LL

    更新日期:1997-04-01 00:00:00

  • Screening for prostate cancer: a review of the evidence for the U.S. Preventive Services Task Force.

    abstract:BACKGROUND:Screening can detect prostate cancer at earlier, asymptomatic stages, when treatments might be more effective. PURPOSE:To update the 2002 and 2008 U.S. Preventive Services Task Force evidence reviews on screening and treatments for prostate cancer. DATA SOURCES:MEDLINE (2002 to July 2011) and the Cochrane ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-155-11-201112060-00375

    authors: Chou R,Croswell JM,Dana T,Bougatsos C,Blazina I,Fu R,Gleitsmann K,Koenig HC,Lam C,Maltz A,Rugge JB,Lin K

    更新日期:2011-12-06 00:00:00

  • D-dimer for the exclusion of acute venous thrombosis and pulmonary embolism: a systematic review.

    abstract:BACKGROUND:Despite extensive literature, the diagnostic role of d-dimer for deep venous thrombosis (DVT) or pulmonary embolism (PE) remains unclear, reflecting multiple d-dimer assays and concerns about differing sensitivities and variability. PURPOSE:To systematically review trials that assessed sensitivity, specific...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.7326/0003-4819-140-8-200404200-00005

    authors: Stein PD,Hull RD,Patel KC,Olson RE,Ghali WA,Brant R,Biel RK,Bharadia V,Kalra NK

    更新日期:2004-04-20 00:00:00

  • Supraventricular arrhythmia in patients having noncardiac surgery: clinical correlates and effect on length of stay.

    abstract:BACKGROUND:Few recent data are available on risk factors for perioperative supraventricular arrhythmia (SVA) after noncardiac surgery or on the effect of SVA on clinical outcomes. OBJECTIVE:To determine the incidence, clinical correlates, and effect on length of stay of perioperative SVA in patients having major nonca...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-129-4-199808150-00003

    authors: Polanczyk CA,Goldman L,Marcantonio ER,Orav EJ,Lee TH

    更新日期:1998-08-15 00:00:00

  • Postpolypectomy colonoscopy surveillance guidelines: predictive accuracy for advanced adenoma at 4 years.

    abstract:BACKGROUND:Lack of confidence in postpolypectomy surveillance guidelines may be a factor in the observed low adherence rates among providers. OBJECTIVE:To assess the 2006 postpolypectomy colonoscopy surveillance guidelines, which recommend 3-year follow-up colonoscopy for individuals with high-risk adenomas (defined a...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.7326/0003-4819-148-6-200803180-00004

    authors: Laiyemo AO,Murphy G,Albert PS,Sansbury LB,Wang Z,Cross AJ,Marcus PM,Caan B,Marshall JR,Lance P,Paskett ED,Weissfeld J,Slattery ML,Burt R,Iber F,Shike M,Kikendall JW,Lanza E,Schatzkin A

    更新日期:2008-03-18 00:00:00

  • Hypomagnesemia and impaired parathyroid hormone secretion in chronic renal disease.

    abstract::Severe hypocalcemia secondary to magnesium depletion has been described in numerous patients with gastrointestinal disorders. The development of profound hypomagnesemia in chronic renal disease is a rare finding. We studied three patients with advanced renal failure and magnesium depletion. Severe hypocalcemia also wa...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-88-2-206

    authors: Mennes P,Rosenbaum R,Martin K,Slatopolsky E

    更新日期:1978-02-01 00:00:00

  • Should This Patient Receive Aspirin?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center.

    abstract::Aspirin exerts antiplatelet effects through irreversible inhibition of cyclooxygenase-1, whereas its anticancer effects may be due to inhibition of cyclooxygenase-2 and other pathways. In 2009, the U.S. Preventive Services Task Force endorsed aspirin for primary prevention of cardiovascular disease. However, aspirin's...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M17-2162

    authors: Burns RB,Graham K,Sawhney MS,Reynolds EE

    更新日期:2017-12-05 00:00:00