当前位置： SCI文献检索 > PHARMACEUTICAL RESEARCH期刊下所有文献 > Textural analysis and flow rheometry of novel, bioadhesive antimicrobial oral gels.

Textural analysis and flow rheometry of novel, bioadhesive antimicrobial oral gels.

Abstract：

PURPOSE:This study examined the rheological and textural characteristics (hardness, compressibilty, adhesiveness and cohesiveness) of bioadhesive oral gels containing the antimicrobial agent chlorhexidine. METHODS:Textural analysis was performed using a Stable Micro Systems texture analyser (model TA-XT 2) in texture profile analysis (TPA) mode. In this, an analytical probe was twice compressed into each formulation to a defined depth (15 mm) and at defined rates (2, 4, 6, 8, 10 mm s-1), allowing a delay period (15 s) between the end of the first and beginning of the second compressions. Flow rheograms were performed using a Carri-Med CSL2-100 rheometer with parallel plate geometry under controlled shearing stresses at 20.0 +/- 0.1 degrees C. RESULTS:All formulations exhibited pseudoplastic flow with thixotropy. Increasing concentrations of each polymer significantly increased formulation hardness, compressibility, adhesiveness and zero-rate viscosity. Increased hardness and compressibility were due to the attendent increased viscosities of these formulations. Increased adhesiveness was related to the concentrations of the (bioadhesive) polymers employed in these formulations and, in addition, was dependent on the physical state of polycarbophil. Formulation viscosity contributed to product adhesiveness, reflecting the importance of product rheology on this parameter. Decreased formulation cohesiveness, observed as the concentrations of the PVP, PC and HEC (3-5% w/w) were increased, was due an increase in semi-solid character. Numerical values of hardness, compressibility and adhesiveness were affected by the choice of probe speed, a parameter related to rate of shear in flow rheometry. Statistical interactions were observed and were assigned to the effects of HEC on the physical state of PVP (dissolved or dispersed) and PC (swollen or unswollen). CONCLUSIONS:This study has demonstrated both the applicability of textural analysis for the mechanical characterisation of bioadhesive semi-solid gel systems and, additionally, the direct influence of viscosity on the parameters defined by textural analysis, namely, hardness, compressibility and adhesiveness.

journal_name

Pharm Res

journal_title

Pharmaceutical research

authors

Jones DS,Woolfson AD,Brown AF

doi

10.1023/a:1012091231023

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

450-7

issue

eissn

0724-8741

issn

1573-904X

journal_volume

pub_type

杂志文章

在线工具

Textural analysis and flow rheometry of novel, bioadhesive antimicrobial oral gels.