Abstract:
:Contrast enhancement of malignant gliomas and the development of peritumoral edema are thought to be due to a breakdown of the blood-brain barrier (BBB). The degree to which these two factors are related to each other or to the degree of damage to the BBB is unknown. Our purpose was to quantitatively correlate the degree of enhancement with Gd-DTPA of anaplastic gliomas and glioblastoma multiforme with the volume of surrounding edema. In 14 patients, quantitative measurements of the volume of peritumoral edema and the degree of contrast enhancement were made. A high degree of correlation was found (r = 0.86, P < 0.01). These results can be viewed as indirect, radiological evidence that edema production is quantitatively related to the degree of breakdown of the BBB as determined by gadolinium enhancement. These results imply that the origin of the edema is in the area of breakdown of the BBB.
journal_name
Neuroradiologyjournal_title
Neuroradiologyauthors
Pronin IN,Holodny AI,Petraikin AVdoi
10.1007/s002340050421subject
Has Abstractpub_date
1997-05-01 00:00:00pages
348-50issue
5eissn
0028-3940issn
1432-1920journal_volume
39pub_type
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