Abstract：
AIMS:Our study aimed to investigate the function of GALNT2 in lung adenocarcinoma (LUAD). MAIN METHODS:We used network tools and tissue microarray immunohistochemistry to measure the expression levels of GALNT2 in LUAD. Kaplan-Meier curves and Cox regression methods were used in survival analysis. We detected the role of GALNT2 in cell lines by Cell Counting Kit-8, colony formation, transwell, and wound healing assays. We performed Western blotting to evaluate downstream protein levels. KEY FINDINGS:GALNT2 was highly expressed in LUAD samples and indicated a poor prognosis. Knockdown of GALNT2 suppressed cell line proliferation, migration, and invasion abilities, while overexpression of GALNT2 enhanced those phenotypes. Moreover, GALNT2 activated Notch/Hes1-PTEN-PI3K/Akt signaling axis. SIGNIFICANCE:Our data confirmed the cancer-promoting effect of GALNT2, and might provide a new approach for LUAD therapy.
journal_name
Life Scijournal_title
Life sciencesauthors
Wang W,Sun R,Zeng L,Chen Y,Zhang N,Cao S,Deng S,Meng X,Yang Sdoi
10.1016/j.lfs.2021.119439keywords:
["GALNT2","Lung adenocarcinoma","Metastasis","Notch","Proliferation"]subject
Has Abstractpub_date
2021-07-01 00:00:00pages
119439eissn
0024-3205issn
1879-0631pii
S0024-3205(21)00424-0journal_volume
276pub_type
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