A minigene DNA vaccine encoding peptide epitopes derived from Galectin-1 has protective antitumoral effects in a model of neuroblastoma.

abstract：:Epidermal growth factor receptor (EGFR), a mediator of mitogenic activity of epidermal growth factor and transforming growth factor-alpha, has been shown to be associated with tumour progression. We have detected a level of EGFR transcript in normal, hyperplastic (BPH) and carcinomatous (CaP) prostate tissues by cytop...

journal_title：Cancer letters

authors： Kumar VL,Majumder PK,Gujral S,Kumar V

更新日期：1998-12-25 00:00:00

abstract：:Inorganic arsenic (As), 1,2-dichloroethane (DCE), vinyl chloride (VC) and trichloroethylene (TCE) are frequently identified as groundwater contaminants near hazardous waste disposal sites. While the carcinogenicity of each of these chemicals has been extensively studied individually, little information exists regardin...

journal_title：Cancer letters

authors： Pott WA,Benjamin SA,Yang RS

更新日期：1998-11-27 00:00:00

abstract：:Hematopoietic toxicity is one of the major problems that limits the effectiveness of many antineoplastic drugs. One approach to overcome this problem is to confer chemoresistance to the hematopoietic cells by gene transfer of drug resistance genes. Human cytidine deaminase (CD) inactivates the cytosine nucleoside anal...

journal_title：Cancer letters

authors： Beauséjour CM,Momparler RL

更新日期：1999-01-08 00:00:00

abstract：:Human pancreatic cancer is stimulated by the autocrine production of gastrin. In this study, the effects of administration of antisense oligonucleotides to gastrin on growth of pancreatic cancer were evaluated in vitro and in vivo. Log phase BxPC-3 human pancreatic cancer cells in culture were exposed to increasing co...

journal_title：Cancer letters

authors： Smith JP,Verderame MF,Zagon IS

更新日期：1999-01-08 00:00:00

abstract：:In vitro and animal studies, the effect of loss of p53 function on radiosensitivity is controversial. p21Waf1/Cip1 is a potent inhibitor of cyclin-dependent kinases and p21 gene polymorphisms are associated with some human cancers. We sought to determine whether p53 mutations or p21 polymorphisms affect response to ra...

journal_title：Cancer letters

authors： Matsuzoe D,Hideshima T,Kimura A,Inada K,Watanabe K,Akita Y,Kawahara K,Shirakusa T

更新日期：1999-01-29 00:00:00

abstract：:Contrary to the earlier generally accepted view that vaccinia virus replicates in the cytoplasm only of suitable target cells, steadily accumulating data show that the viral genome spends a limited period of time in the nucleus. This, together with the many cases where a close association has been suspected or establi...

journal_title：Cancer letters

authors： Michel N,Aguilera A,Miller A,Miller AO

更新日期：1976-03-01 00:00:00

abstract：:Groups of male MRC Wistar rats were treated for 2 years either with morpholine (10 g/kg food) together with sodium nitrite (3 g/l drinking water) or with N-nitrosomorpholine (NM, 0.15g/l drinking water). In both cases, a group of rats was given sodium ascorbate (22.7 g/kg food) in addition to these treatments. When as...

journal_title：Cancer letters

authors： Mirvish SS,Pelfrene AF,Garcia H,Shubik P

更新日期：1976-11-01 00:00:00

abstract：:Exposure of A2780 human ovarian tumor cells to a low concentration of melphalan in vitro for 7 days resulted in the development of melphalan resistance. This resistance was not a stable characteristic of the cells since it was lost after 2 weeks in culture in the absence of drug. The melphalan-resistant cells exhibite...

journal_title：Cancer letters

authors： Caffrey PB,Zhu M,Zhang Y,Chinen N,Frenkel GD

更新日期：1999-02-08 00:00:00

abstract：:Paclitaxel stabilizes microtubules with inhibition of mitotic spindle formation and has been found effective in several solid cancers. To test whether paclitaxel could be cytotoxic in human HCC cell lines, we used established HuH-7 and HepG2 cell lines. Changes in cell number, DNA synthesis rates and cell viability we...

journal_title：Cancer letters

authors： Gagandeep S,Novikoff PM,Ott M,Gupta S

更新日期：1999-02-08 00:00:00

abstract：:Primary mammary adenocarcinomas of C3H mice were dissociated to single cells. These cells were seeded at a density of 5 x 10(5)/cm2 substrate area and were grown as monolayers for 36 days in high-serum medium supplemented with insulin. Cultures became confluent within a few days and confluence was maintained throughou...

journal_title：Cancer letters

authors： Hosick HL

更新日期：1976-03-01 00:00:00

abstract：:The authors previously identified a silencer of the rat IGFBP-2 gene. Sequence examination of the silencer has revealed that it contains the target sequence for the pRb (retinoblastoma) tumour suppressor gene, referred to as the retinoblastoma control element (RCE) which is frequently found in the regulatory element o...

journal_title：Cancer letters

authors： Kutoh E,Margot JB,Schwander J

更新日期：1999-03-01 00:00:00

abstract：:Hydroxymethyl-glutaryl-CoA-reductase (HMG-CoA-reductase), the key enzyme for cholesterol synthesis and essential for the synthesis of the precursor for p21ras farnesylation, was inhibited in neuroblastoma cells by lovastatin or L-ascorbic acid. Both compounds inhibited clonogenic colony formation of neuroblastoma cell...

journal_title：Cancer letters

authors： Girgert R,Vogt Y,Becke D,Bruchelt G,Schweizer P

更新日期：1999-04-01 00:00:00

abstract：:Tryptamine is an endogenous neuroactive metabolite of tryptophan. Interpretation of the function of this bioamine, however, is restricted to manipulation with tryptamine synthetic pathways. Meanwhile, tryptamine is a potent inhibitor of protein biosynthesis, via the competitive inhibition of tryptophanyl-tRNA syntheta...

journal_title：Cancer letters

authors： Paley EL

更新日期：1999-03-22 00:00:00

abstract：:Selective depletion or inactivation of specific myeloid populations (neutrophils, macrophages) and lymphoid populations (helper T cells, cytolytic T cells) in EMT6 sarcoma-bearing mice was used to determine the contribution of each of these host immune cell types to the curative outcome of Photofrin-based photodynamic...

journal_title：Cancer letters

authors： Korbelik M,Cecic I

更新日期：1999-03-22 00:00:00

abstract：:Cisplatin-resistant KCP-4 cells were 12.4- and 31.6-fold more resistant to CPT-11 and SN-38 than parental KB-3-1 cells, respectively. We studied the mechanism of cross-resistance to CPT-11 and SN-38. Our previous study showed that multidrug resistance protein (MRP), canalicular multispecific organic anion transporter ...

journal_title：Cancer letters

authors： Chen ZS,Sumizawa T,Furukawa T,Ono K,Tani A,Komatsu M,Akiyama S

更新日期：1999-04-26 00:00:00

abstract：:In a search for anti-tumor-promoting agents, we carried out a primary screening of twenty-nine 8-substituted and four 6-substituted derivatives of 7-methoxycoumarins isolated from plants of the Murraya and/or Citrus species (Rutaceae), examining their possible inhibitory effects on Epstein-Barr virus early antigen (EB...

journal_title：Cancer letters

authors： Ito C,Itoigawa M,Furukawa H,Tokuda H,Okuda Y,Mukainaka T,Okuda M,Nishino H

更新日期：1999-04-26 00:00:00

abstract：:Primary and pulmonary metastatic and pulmonary metastatic tumors (two synchronous and seven metachronous metastases) in nine patients with osteosarcomas were studied by DNA cytofluorometry. All patients were treated with both pre and postoperative chemotherapy. The results showed that all five diploid osteosarcomas an...

journal_title：Cancer letters

authors： Kusuzaki K,Hashiguchi S,Hirata M,Takeshita H,Murata H,Ashihara T,Hirasawa Y

更新日期：1999-04-26 00:00:00

abstract：:To define the commonly deleted region on chromosome 8p for further positional cloning of the putative tumor suppressor gene, we carried out allelic imbalance (AI) studies in 41 HCCs using a panel of 37 microsatellite markers. The overall AI on 8p was 87.8% (36 of 41). Among the 36 cases with AI, 13 cases showed AI in ...

journal_title：Cancer letters

authors： Piao Z,Kim NG,Kim H,Park C

更新日期：1999-04-26 00:00:00

abstract：:Dehydrozingerone, 4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one, is half an analog of curcumin which is known to have anti-tumor activity. The anti-tumor promoting activity of dehydrozingerone was evaluated by determining the inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetra...

journal_title：Cancer letters

authors： Motohashi N,Yamagami C,Tokuda H,Konoshima T,Okuda Y,Okuda M,Mukainaka T,Nishino H,Saito Y

更新日期：1998-12-11 00:00:00

abstract：:We investigated the secretion of insulin-like growth factor binding proteins (IGFBPs) by estrogen-dependent ZR-75-1 and MCF-7 human breast cancer cells, and tamoxifen-resistant (ZR-75-9a1 and LY2) and estrogen-independent (ZR-PR-LT) variants which express altered levels of IGF-I receptor. IGFBP species (35 kDa and 44 ...

journal_title：Cancer letters

authors： Maxwell P,van den Berg HW

更新日期：1999-05-24 00:00:00

abstract：:This experiment was carried out to clarify the roles of diesel exhaust particle (DEP) extracts and the promotive effects of nitrogen dioxide (NO2) and/or sulfur dioxide (SO2) exposure on rat lung tumorigenesis. F344 male rats were intratracheally administered DEP extract-coated carbon black particles (DEcCBP) and expo...

journal_title：Cancer letters

authors： Ohyama K,Ito T,Kanisawa M

更新日期：1999-05-24 00:00:00

abstract：:Arachidonic acid is stored in the cell membrane and released when the cell is activated by appropriate stimuli. It is the substrate for prostaglandins. Both experimental and human tumors often synthesize high levels of prostaglandins, most notably prostaglandin E2 (PGE2). Some experiments suggest that these compounds ...

journal_title：Cancer letters

authors： Kökoğlu E,Tüter Y,Sandikçi KS,Yazici Z,Ulakoğlu EZ,Sönmez H,Ozyurt E

更新日期：1998-10-23 00:00:00

abstract：:Overexpression of the c-erbB-2 oncoprotein has been detected in human adenocarcinoma of the breast, cervix and salivary gland, in all of which an association between the overexpression of the c-erbB-2 and a poor prognosis of the disease has been reported. However, the prognostic role of c-erbB-2 oncoprotein in ovarian...

journal_title：Cancer letters

authors： Kim YT,Kim JW,Lee JW

更新日期：1998-10-23 00:00:00

abstract：:Phorbol esters, known activators of c- and n-protein kinase C (PKC) isoforms, play a pivotal role in tumor promotion. In order to better understand the relationships between PKC activation, the metastatic potential and the proliferative capacity, we have analyzed the effect of 12-O-tetradecanoylphorbol-13-acetate (TPA...

journal_title：Cancer letters

authors： La Porta CA,Porro D,Comolli R

更新日期：1998-10-23 00:00:00

abstract：:L-Canavanine (L-CAV) is a naturally occurring L-arginine analog that induces the formation of non-functional proteins in a variety of organisms. Previous studies have shown that L-CAV is cytotoxic for several human tumor cell lines. In this study, we have evaluated the cytotoxicity of L-CAV for both parental and multi...

journal_title：Cancer letters

authors： Worthen DR,Chien L,Tsuboi CP,Mu XY,Bartik MM,Crooks PA

更新日期：1998-10-23 00:00:00

abstract：:Aromatase, the enzyme system catalyzing estrogen biosynthesis, is found in stromal tissue in the breast. The increased expression of the aromatase CYP19 gene in breast cancer tissues was recently associated with a promoter region regulated through cAMP-mediated pathways. PGE2, derived from cyclooxygenase, increases in...

journal_title：Cancer letters

authors： Brueggemeier RW,Quinn AL,Parrett ML,Joarder FS,Harris RE,Robertson FM

更新日期：1999-06-01 00:00:00

abstract：:High-fiber diets have been shown to have beneficial effects on preventing tumorigenesis. Inositol hexaphosphate (InsP6 or phytic acid) which is a fiber-associated component of cereals and legumes has been demonstrated to inhibit cell proliferation and enhance cell differentiation, indicating its potential for chemopre...

journal_title：Cancer letters

authors： Nickel KP,Belury MA

更新日期：1999-06-01 00:00:00

abstract：:In order to evaluate any connection between phospholipid metabolism and the dexamethasone resistance in CEM-C1-15 leukemic cells, a phosphonium analog of choline was used to study the phospholipid metabolism in dexamethasone-sensitive and dexamethasone-resistant leukemic cells using 31P-NMR spectroscopy. Measurements ...

journal_title：Cancer letters

authors： Adebodun F

更新日期：1999-06-01 00:00:00

abstract：:The effects of vincristine (VC) and 6-mercaptopurine (6-MP) on body weight, regional weights, and the contents of putrescine, spermidine, and spermine in six regions of the brain were examined in rats that had been given these drugs for 5 consecutive days. VC is recommended for management of tumors in the corpus stria...

journal_title：Cancer letters

authors： Watanabe S,Sato S,Nagase S,Shimosato K,Ohkuma S

更新日期：1999-05-03 00:00:00

abstract：:The chemosensitivity of the sequence of steps responsible for metastasis formation including circulating tumor cells and micrometastases to a 5-fluorouracil derivative (UFT) was examined with a novel micrometastasis model featuring Lewis lung carcinoma cells tagged with the bacterial LacZ gene and hygromycinR gene (hy...

journal_title：Cancer letters

authors： Nakanishi H,Kobayashi K,Nishimura T,Inada K,Tsukamoto T,Tatematsu M

更新日期：1999-07-19 00:00:00