Salivary innate defense system in type 1 diabetes mellitus in children with mixed and permanent dentition.

Abstract:

OBJECTIVE:It should be expected that type 1 diabetes mellitus may disturb innate and acquired immunity. There are no data on type 1 diabetes mellitus-related changes in the salivary flow and the protein output responsible for the innate immunity of saliva depending on the quality of dentition reflecting the age of child. The aim of this work was the evaluation of parameters responsible for the innate immunity of saliva in children and adolescents with type 1 diabetes mellitus. MATERIALS AND METHODS:In diabetic children, adolescent and healthy volunteers, the salivary flow, the output and the concentration of the activity of peroxidase (colorimetry), lysozyme (radial immunodiffusion) and lactoferrin (ELISA) were determined. RESULTS:In children with mixed and permanent dentition, type 1 diabetes mellitus significantly decreases (as compared with the appropriate controls) the unstimulated salivary flow, the output, concentration of peroxidase and the output of the lysozyme and lactoferrin. CONCLUSION:In conclusion, it may be stated that type 1 diabetes mellitus causes functional changes in the salivary glands, resulting in a decrease of the salivary flow and weakening of the salivary innate defense system, thus creating a threat to the oral and general health of type 1 diabetes mellitus children. The results showed that the salivary glands of younger children, when compared to adolescents with type 1 diabetes mellitus, are more susceptible to the injurious effects of the disease.

journal_name

Acta Odontol Scand

authors

Zalewska A,Knaś M,Kuźmiuk A,Waszkiewicz N,Niczyporuk M,Waszkiel D,Zwierz K

doi

10.3109/00016357.2013.773071

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

1493-500

issue

6

eissn

0001-6357

issn

1502-3850

journal_volume

71

pub_type

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