Abstract:
INTRODUCTION:Nuclear factor (NF)-κB, as transcription factor, is linked to the expression of various genes and plays an essential role in immune and inflammatory responses. Abnormal NF-κB signaling results in human diseases, such as immune disorders, inflammation and various cancers. Therefore, regulation of NF-κB may treat or improve the symptoms in human disorders. AREAS COVERED:This review provides information on recent NF-κB inhibitor-related patents from 2006 to 2010. The patents are explained and categorized by mechanism. The reader will gain an understanding of NF-κB function and the structure and biological activity of recently developed NF-κB inhibitors that may be new drug candidates. EXPERT OPINION:NF-κB plays an essential role in the human body and thus regulation of NF-κB is very important for the treatment of diseases. Furthermore, patented compounds and peptides are available as lead compounds in drug development studies.
journal_name
Expert Opin Ther Patjournal_title
Expert opinion on therapeutic patentsauthors
Kwak JH,Jung JK,Lee Hdoi
10.1517/13543776.2011.638285subject
Has Abstractpub_date
2011-12-01 00:00:00pages
1897-910issue
12eissn
1354-3776issn
1744-7674journal_volume
21pub_type
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journal_title:Expert opinion on therapeutic patents
pub_type: 杂志文章,评审
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journal_title:Expert opinion on therapeutic patents
pub_type: 杂志文章,评审
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journal_title:Expert opinion on therapeutic patents
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journal_title:Expert opinion on therapeutic patents
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journal_title:Expert opinion on therapeutic patents
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journal_title:Expert opinion on therapeutic patents
pub_type: 杂志文章,评审
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更新日期:2019-03-01 00:00:00
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journal_title:Expert opinion on therapeutic patents
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journal_title:Expert opinion on therapeutic patents
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journal_title:Expert opinion on therapeutic patents
pub_type: 杂志文章,评审
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journal_title:Expert opinion on therapeutic patents
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journal_title:Expert opinion on therapeutic patents
pub_type: 杂志文章,评审
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journal_title:Expert opinion on therapeutic patents
pub_type: 杂志文章,评审
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journal_title:Expert opinion on therapeutic patents
pub_type: 杂志文章,评审
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更新日期:2011-11-01 00:00:00
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journal_title:Expert opinion on therapeutic patents
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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journal_title:Expert opinion on therapeutic patents
pub_type: 杂志文章,评审
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更新日期:2010-03-01 00:00:00
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journal_title:Expert opinion on therapeutic patents
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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journal_title:Expert opinion on therapeutic patents
pub_type: 杂志文章
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更新日期:2015-05-01 00:00:00
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journal_title:Expert opinion on therapeutic patents
pub_type: 杂志文章,评审
doi:10.1517/13543776.2013.828036
更新日期:2013-11-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Expert opinion on therapeutic patents
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journal_title:Expert opinion on therapeutic patents
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journal_title:Expert opinion on therapeutic patents
pub_type: 杂志文章
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journal_title:Expert opinion on therapeutic patents
pub_type: 杂志文章
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journal_title:Expert opinion on therapeutic patents
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journal_title:Expert opinion on therapeutic patents
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journal_title:Expert opinion on therapeutic patents
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更新日期:2013-09-01 00:00:00
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journal_title:Expert opinion on therapeutic patents
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journal_title:Expert opinion on therapeutic patents
pub_type: 杂志文章,评审
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更新日期:2018-11-01 00:00:00
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journal_title:Expert opinion on therapeutic patents
pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00
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journal_title:Expert opinion on therapeutic patents
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