Abstract：
PURPOSE:To evaluate the effect of a fixed combination of brimonidine-timolol on intraocular pressure (IOP) after phacoemulsification cataract surgery. SETTING:Department of Ophthalmology, Patras University Hospital, Patras, Greece. DESIGN:Prospective randomized comparative case series. METHODS:Patients scheduled for phacoemulsification were randomly assigned to 1 of 2 groups. The treatment group received 1 drop of brimonidine-timolol fixed combination immediately after surgery, and the control group received no treatment. The IOP was measured preoperatively and 6, 12, and 24 hours postoperatively. RESULTS:The treatment group comprised 28 eyes and the control group, 30 eyes. The mean IOP increased by 0.14 mm Hg ± 3.88 (SD) (P = .88) in the treatment group and increased by 2.8 ± 5.01 mm Hg (P = .007) in the control group. Twelve hours after surgery, the mean IOP decreased by -0.57 ± 3.82 mm Hg (P = .49) in the treatment group and increased by 2.20 ± 4.56 mm Hg (P = .009) in the control group. Twenty-four hours after surgery, the mean IOP decreased by -1.57 ± 2.30 mm Hg (P=.012) in the treatment group and increased by 0.86 ± 4.21 mm Hg (P = .175) in the control group. The mean IOP change between the 2 study groups 6, 12, and 24 hours postoperatively was statistically significantly different (P = .015, P = .006, and P = .003; respectively). CONCLUSION:The fixed brimonidine-timolol combination effectively reduced IOP 6, 12, and 24 hours after phacoemulsification cataract surgery.
journal_name
J Cataract Refract Surgjournal_title
Journal of cataract and refractive surgeryauthors
Pharmakakis N,Giannopoulos K,Stasinos S,Makri OE,Georgakopoulos CDdoi
10.1016/j.jcrs.2010.08.046subject
Has Abstractpub_date
2011-02-01 00:00:00pages
279-83issue
2eissn
0886-3350issn
1873-4502pii
S0886-3350(10)01720-7journal_volume
37pub_type
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journal_title：Journal of cataract and refractive surgery
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journal_title：Journal of cataract and refractive surgery
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journal_title：Journal of cataract and refractive surgery
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journal_title：Journal of cataract and refractive surgery
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journal_title：Journal of cataract and refractive surgery
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