Modeling blast induced neurotrauma in isolated spinal cord white matter.

Abstract:

:Blast-induced neurotrauma (BINT) is a common injury associated with the present military conflicts. Exposure to the shock-wave produced from exploding ordnances leads to significant neurological deficits throughout the brain and spinal cord. Prevention and treatment of this injury requires an appropriate understanding of the mechanisms governing the neurological response. Here, we present a novel ex-vivo BINT model where an isolated section of guinea pig spinal cord white matter is exposed to the shock-wave produced from a small scale explosive event. Additionally, we define the relationship between shock-wave impact, tissue deformation and resulting anatomical and functional deficits associated with BINT. Our findings suggest an inverse relationship between the magnitude of the shock-wave overpressure and the degree of functional deficits using a double sucrose gap recording chamber. Similar correlations are drawn between overpressure and degree of anatomical damage of neuronal processes using a dye-exclusion assay. The following approach is expected to significantly contribute to the detection, mitigation and eventual treatment of BINT.

journal_name

J Med Syst

authors

Connell S,Ouyang H,Shi R

doi

10.1007/s10916-010-9464-5

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

765-70

issue

5

eissn

0148-5598

issn

1573-689X

journal_volume

35

pub_type

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