Sonographic assessment of tumor response: from in vivo models to clinical applications.

Abstract:

:The advent of antiangiogenic drugs in cancer therapy necessitates an imaging modality that can longitudinally assess posttreatment changes in tumor vasculature. In this regard, microbubble contrast-enhanced ultrasonography (CEUS) offers several advantages over conventional imaging modalities. The small size of microbubbles (approximately 2-3 mum) permits their retention in the intravascular compartment and travel through the tortuous tumor vasculature. Mathematical models applied to signal intensity versus time depicting the kinetics of microbubble flow through the tumor are used to characterize tumor vascular density, blood flow velocity, and perfusion. In vivo studies using CEUS have demonstrated its comparability to dynamic contrast-enhanced magnetic resonance imaging and fluorodeoxyglucose positron emission tomography in distinguishing between diseased or malignant tissue and normal tissue. Moreover, CEUS has great potential for other novel clinical applications such as improved cancer diagnosis, enhanced medication delivery, and early antiangiogenic cancer treatment response evaluation. This review discusses the principles and potential clinical applications of CEUS in determining tumor response and its promising role in enhancing medication delivery in certain tumors.

journal_name

Ultrasound Q

journal_title

Ultrasound quarterly

authors

Hwang M,Niermann KJ,Lyshchik A,Fleischer AC

doi

10.1097/RUQ.0b013e3181bce364

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

175-83

issue

4

eissn

0894-8771

issn

1536-0253

pii

00013644-200912000-00003

journal_volume

25

pub_type

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