Quantitative study of Leydig cell populations in mice exposed to low doses of cadmium.

Abstract:

:Leydig cell morphological changes were evaluated using morphometric and stereological methods in male mice exposed to low doses of cadmium. A possible reversibility of the changes after cadmium withdrawal was also considered. Nuclear morphological parameters and stereological densities of the Leydig cell population were lower in the cadmium-exposed groups than in the control. The withdrawal of cadmium did not lead to any significant recovery of the morphological parameters. Nevertheless, numerical density increased significantly in the withdrawn groups, suggesting that the hyperplasia of interstitial cells could try to relieve morphological damage after cadmium withdrawal.

authors

Blanco A,Moyano MR,Molina AM,Blanco C,Flores-Acuña R,García-Flores JR,Espada M,Monterde JG

doi

10.1007/s00128-009-9700-1

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

756-60

issue

6

eissn

0007-4861

issn

1432-0800

journal_volume

82

pub_type

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