Mediator responses in surgical infections.

Abstract:

BACKGROUND:Surgical infections, and sepsis in particular, are characterized by extensive release of mediators. Our laboratories have been interested in understanding how these substances contribute to morbidity and mortality during various stages of surgical infections in order to develop new and more effective therapeutics and treatment strategies. METHODS:In a series of in vitro studies, human plasma was exposed to lipopolysaccharide (LPS), and whole blood was treated with peptidoglycan from Staphylococcus aureus. The activity of peptidoglycan also was studied in the rat, and LPS infusion was tested in dog and pig models. In a clinical study, the relation of serum LPS to multiple organ dysfunction and failure was studied in patients in the surgical intensive care unit. RESULTS:Exposure of plasma to LPS led to formation of bradykinin, activation of the plasma kallikrein-kinin system, and reduction of kallikrein inhibitor capacity. The coagulation, fibrinolysis, and complement cascades were activated. Peptidoglycan caused rapid release of tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 from macrophages and activation of the genes encoding pro-inflammatory and anti-inflammatory cytokines. In the rat, peptidoglycan induced cytokine release, caused liver and kidney dysfunction, and induced matrix metalloproteinase-9 (MMP-9) activity in the liver and lung. In the dog and pig, LPS caused substantial activation of plasma proteases. Clinically, a finding of LPS in the plasma was associated with multiple organ dysfunction and failure. These patients also revealed substantial activation of the plasma cascade systems, as well as systemic cytokine release. CONCLUSION:On the basis of these observations, we developed a monitoring system to recognize early signs of infection.

journal_name

Surg Infect (Larchmt)

journal_title

Surgical infections

authors

Aasen AO,Wang JE

doi

10.1089/sur.2006.7.s2-3

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

S3-4

eissn

1096-2964

issn

1557-8674

journal_volume

7 Suppl 2

pub_type

杂志文章,评审
  • New strategies to improve outcomes in the surgical intensive care unit.

    abstract:BACKGROUND:Over the last half-decade, substantial breakthroughs have taken place in terms of routine therapy of critically ill patients. The combination of these strategies has the potential to result in improvement in the overall outcomes for patients in intensive care units. METHODS:A focused review was undertaken o...

    journal_title:Surgical infections

    pub_type: 杂志文章,评审

    doi:10.1089/sur.2004.5.289

    authors: Beilman GJ

    更新日期:2004-10-01 00:00:00

  • Active hexose correlated compound (AHCC) enhances resistance to infection in a mouse model of surgical wound infection.

    abstract:BACKGROUND:Infection is the most common postoperative complication within the surgical wound and during severe trauma. In spite of the use of modern sterile techniques and prophylaxis, infection continues to be a leading cause of death in these patients. Therefore, it has become crucial to develop new alternatives to p...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2006.7.527

    authors: Aviles H,O'Donnell P,Sun B,Sonnenfeld G

    更新日期:2006-12-01 00:00:00

  • Abdominal wall thickness: is it associated with superficial and deep incisional surgical site infection after colorectal surgery?

    abstract:BACKGROUND:Colorectal surgical procedures have a high rate of surgical site infection (SSI), and obesity has been implicated as a predictor of such infection. We hypothesized that abdominal wall thickness (AWT), as a metric of obesity, would predict postoperative superficial and deep incisional SSI after colorectal sur...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2012.109

    authors: Kwaan MR,Sirany AM,Rothenberger DA,Madoff RD

    更新日期:2013-08-01 00:00:00

  • Fever after percutaneous nephrolithotomy: contributing factors.

    abstract:BACKGROUND AND PURPOSE:The exact mechanism of fever and urosepsis after percutaneous procedures has not been established. This research studied the frequency of fever after percutaneous nephrolithotomy (PCNL) and the contributing factors. METHODS:In a cross-sectional study, from September 2003 to March 2004, all 217 p...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2006.7.367

    authors: Sharifi Aghdas F,Akhavizadegan H,Aryanpoor A,Inanloo H,Karbakhsh M

    更新日期:2006-08-01 00:00:00

  • Evaluation of Tigecycline Efficacy and Post-Discharge Outcomes in a Clinical Practice Population with Complicated Intra-Abdominal Infection: A Propensity Score-Matched Analysis.

    abstract:BACKGROUND:The utility of tigecycline as compared with other antibiotic therapies in the treatment of patients with complicated intra-abdominal infection (cIAI) and the short- and long-term outcomes of a large cohort of severely ill patients were examined. We provide the first published data on post-discharge events fo...

    journal_title:Surgical infections

    pub_type: 杂志文章,多中心研究

    doi:10.1089/sur.2015.075

    authors: Solomkin J,Mullins CD,Quintana A,Eckmann C,Shelbaya A,Ernst FR,Krukas MR,Reisman A

    更新日期:2016-08-01 00:00:00

  • Fungal Isolates in Peritoneal Fluid Culture Do Not Impact Peri-Operative Outcomes of Peptic Ulcer Perforation.

    abstract:: Background: Fungal isolates from peritoneal fluid sampling in patients with perforated peptic ulcer (PPU) is not uncommon and its management unclear. This study aims to evaluate whether the presence of fungus in peritoneal fluid cultures is a predictor of morbidity and mor...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2019.024

    authors: Kwan JR,Lim M,Ng F,Shelat V

    更新日期:2019-12-01 00:00:00

  • Infection Rates after Periocular Surgery Utilizing New versus Re-Processed Monopolar Electrocautery.

    abstract:BACKGROUND:To determine if there is a difference in periocular post-operative infection rates when utilizing new versus re-processed monopolar electrocautery tips. METHODS:Retrospective cohort study of 4,976 consecutive surgical cases involving 17,149 procedures. Post-operative infections were identified using chart r...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2014.055

    authors: Czyz CN,Abramowitz BD,Goodman AE,Foster JA,Cahill KV,Everman KR

    更新日期:2015-06-01 00:00:00

  • Safety of excisional inguinal lymph node biopsies performed for research purposes in HIV-1-infected women and men.

    abstract:BACKGROUND:Most HIV-1 replication occurs in secondary lymphoid tissues, and evaluating these tissues is crucial to investigations of pathogenesis. Inguinal lymph nodes (LN) are obtained frequently for these studies as they are readily detectable in most individuals and provide abundant numbers of cells. Knowledge of th...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2013.218

    authors: Meditz AL,Connick E,McCarter M

    更新日期:2014-08-01 00:00:00

  • Comparison of Traditional and Skin-Sparing Approaches for Surgical Treatment of Necrotizing Soft-Tissue Infections.

    abstract:: Background: A skin-sparing approach for the treatment of necrotizing soft-tissue infections (NSTIs) removes necrotic tissue planes while leaving viable overlying skin. Subsequent closure of the spared skin may decrease the need for graft-based reconstruction, which is asso...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2019.263

    authors: Tom LK,Maine RG,Wang CS,Parent BA,Bulger EM,Keys KA

    更新日期:2020-05-01 00:00:00

  • Surgery for appendicitis: is it necessary?

    abstract:BACKGROUND:Appendectomy for acute appendicitis is an effective, universally accepted procedure performed more than 300,000 times annually in the United States. It is generally believed that appendicitis progresses invariably from early inflammation to later gangrene and perforation, and that appendectomy is required fo...

    journal_title:Surgical infections

    pub_type: 杂志文章,评审

    doi:10.1089/sur.2007.079

    authors: Mason RJ

    更新日期:2008-08-01 00:00:00

  • Comprehensive Approach to Reduce Surgical Site Infections in Patients Undergoing Neurosurgical Procedures.

    abstract:: Background: Surgical site infections (SSIs) are recognized complications of surgical procedures. Methicillin-resistant Staphylococcus aureus (MRSA) colonization increases the likelihood of developing SSIs. Decolonization of MRSA has been shown to reduce post-operative SSIs...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2020.020

    authors: Nusair AR,El Nekidy WS,Reynolds L,Evans D,El-Lababidi R,Alatoom A

    更新日期:2020-05-04 00:00:00

  • Relevance and utility of peritoneal cultures in patients with peritonitis.

    abstract:BACKGROUND:The pathogenic organisms responsible for the manifestations of secondary peritonitis have been well characterized through almost 30 years of experimental and clinical studies. Enteric gram-negative organisms and anaerobes predominate, with Escherichia coli and Bacteroides fragilis, respectively, being the mo...

    journal_title:Surgical infections

    pub_type: 杂志文章,评审

    doi:10.1089/109629601750469474

    authors: Nathens AB

    更新日期:2001-07-01 00:00:00

  • History of Urinary Retention Is a Risk Factor for Infection after Prostate Biopsy: A Nationwide, Population-Based Cohort Study.

    abstract:BACKGROUND AND AIM:Infection or bleeding after transrectal prostate biopsy remains a concern of both patients and urologists. We explored the risk of association of certain co-morbidities with both complications. PATIENTS AND METHODS:Using the Taiwan National Health Insurance Research Database, we identified patients ...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2018.174

    authors: Lin SL,Lin CT,Huang WT,Jou YC,Tzai TS,Tsai YS

    更新日期:2019-04-01 00:00:00

  • Hand infections: basic principles and management.

    abstract:BACKGROUND:An untreated hand infection can lead rapidly to tissue destruction and permanent disability. METHODS:Review of the pertinent English literature. RESULTS:Early diagnosis and timely, effective intervention is crucial to treatment. Anatomically, the hand consists of multiple potential spaces and tissue planes...

    journal_title:Surgical infections

    pub_type: 杂志文章,评审

    doi:10.1089/sur.2004.5.210

    authors: Spann M,Talmor M,Nolan WB

    更新日期:2004-07-01 00:00:00

  • Fascia-to-fascia closure with abdominal topical negative pressure for severe abdominal infections: preliminary results in a department of general surgery and intensive care unit.

    abstract:BACKGROUND:Vacuum-assisted fascial closure (VAFC-KCI(®)) of an open abdomen is one of the latest methods. METHODS:A prospective observational study was performed with medical records of nine patients who had been treated by abdominal VAFC-KCI(®) from March 2006 to October 2007 in the Department of Surgical Sciences, U...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2010.042

    authors: Padalino P,Dionigi G,Minoja G,Carcano G,Rovera F,Boni L,Dionigi R

    更新日期:2010-12-01 00:00:00

  • Femoral Osteomyelitis Caused by Cladophialophora in a Patient without Known Immunocompromise.

    abstract:BACKGROUND:Chronic osteomyelitis associated with a stage IV decubitus ulcer is a challenging condition to manage, characterized by frequent relapses and need for long-term anti-microbial therapy. Although gram-positive cocci are the most common causes, fungal infections have been reported, usually in immunocompromised ...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2018.046

    authors: Jain NS,Horn CB,Coleoglou Centeno AA,Ilahi ON,Mazuski JE,Bocchichio GV,Punch LJ

    更新日期:2018-07-01 00:00:00

  • Effect of Hand Antisepsis Agent Selection and Population Characteristics on Surgical Site Infection Pathogens.

    abstract:BACKGROUND:Selection of a pre-operative hand antisepsis agent has not been studied in relation to surgical site infection (SSI) culture data. In our hospital, we introduced an alcohol-based hand rub (ABR) in 2012 as an alternative to traditional aqueous surgical scrubs (TSS). It was the goal of this study to review any...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2016.125

    authors: Oriel BS,Chen Q,Wong K,Itani KMF

    更新日期:2017-05-01 00:00:00

  • Tubercular temporalis abscess with skull and dural invasion.

    abstract:BACKGROUND:Mycobacterium tuberculosis infection rarely penetrates both skull and dura with temporalis muscle abscess formation. METHODS:Case report and review of the literature. RESULTS:A non-immunocompromised female patient with a right temporal mass underwent surgical resection. The tubercular abscess extended from...

    journal_title:Surgical infections

    pub_type: 杂志文章,评审

    doi:10.1089/sur.2012.106

    authors: Yan JL,Wei KC

    更新日期:2013-10-01 00:00:00

  • Trauma and Antimicrobial Resistance Are Independent Predictors of Inadequate Empirical Antimicrobial Treatment of Ventilator-Associated Pneumonia in Critically Ill Patients.

    abstract:: Background: We aimed to assess independent risk factors for inadequate initial antimicrobial treatment (IAT) in critically ill patients with ventilator-associated pneumonia (VAP) treated in intensive care units (ICU) and to determine whether IAT is associated with adverse ...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2020.306

    authors: Jovanovic B,Djuric O,Hadzibegovic A,Jovanovic S,Stanisavljevic J,Milenkovic M,Rajkovic M,Ratkovic S,Markovic-Denic L

    更新日期:2021-01-13 00:00:00

  • Awareness of Practice and Comparison with Best Evidence in Surgical Site Infection Prevention in Colorectal Surgery.

    abstract:: Background: The use of mechanical bowel preparation and prophylaxis with oral antimicrobial agents can prevent surgical site infection (SSI) in colorectal surgical procedures, but routine adoption of these and other practices by surgeons has been limited. The aim of this s...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2019.203

    authors: Badia JM,Casey AL,Rubio-Pérez I,Arroyo-García N,Espin E,Biondo S,Balibrea JM

    更新日期:2020-04-01 00:00:00

  • Trends in postoperative sepsis: are we improving outcomes?

    abstract:BACKGROUND AND PURPOSE:Each year, as many as two million operations are complicated by surgical site infections in the United States, and surgical patients account for 30% of patients with sepsis. The purpose of this study was to determine recent trends in sepsis incidence, severity, and mortality rate after surgical p...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2008.046

    authors: Vogel TR,Dombrovskiy VY,Lowry SF

    更新日期:2009-02-01 00:00:00

  • Prophylactic Gentamicin Is Not Associated with Acute Kidney Injury in Patients with Open Fractures.

    abstract:BACKGROUND:Data on antimicrobial prophylaxis for open fractures is limited, with many protocols based on expert recommendations. These protocols include aminoglycosides (AGs) for fractures with significant soft tissue injury, but these drugs are associated with acute kidney injury (AKI) in other settings; this risk has...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2015.086

    authors: Tessier JM,Moore B,Putty B,Gandhi RR,Duane TM

    更新日期:2016-12-01 00:00:00

  • Outcomes of operative management of appendicitis.

    abstract:BACKGROUND:There has not been an appraisal of outcomes of appendectomy for more than 10 years. More reliable diagnostic techniques and minimally invasive surgery are now in widespread use, yet the impact of these advances remains unknown. METHODS:A retrospective review was performed of 453 patients who underwent appen...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2011.104

    authors: Dhupar R,Evankovich J,Ochoa JB,Vargas LG,Hughes SJ

    更新日期:2012-06-01 00:00:00

  • New antibiotic agents: problems and prospects.

    abstract:BACKGROUND:Surgical site infections are the third most common healthcare-associated infection, often leading to prolonged hospital stay and excessive expenditures. Management of these infections has become more challenging due to rising rates of multi-drug-resistant organisms and few new antibiotic options. METHODS:Th...

    journal_title:Surgical infections

    pub_type: 杂志文章,评审

    doi:

    authors: Weber DJ,Rutala WA

    更新日期:2005-01-01 00:00:00

  • Clostridium perfringens surgical site infection after osteotomy for knee deformity correction in a non-immunocompromised child.

    abstract:BACKGROUND:Clostridium perfringens myonecrosis following an elective surgical procedure in a previously healthy child is a rare incident. METHODS:Case report and literature review. RESULTS:A two-year old boy admitted for elective bilateral osteotomies of tibiae was detected to be febrile at day one post-operatively w...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2012.192

    authors: Abd Rashid AH,Ramli R,Ibrahim S

    更新日期:2014-10-01 00:00:00

  • Vancomycin versus linezolid in the treatment of methicillin-resistant Staphylococcus aureus meningitis.

    abstract:BACKGROUND:Vancomycin is the mainstay of treatment for methicillin-resistant Staphylococcus aureus (MRSA) meningitis. However, successful outcomes with linezolid have not been reported in a large series of patients. We conducted a single-center retrospective cohort study to compare vancomycin with linezolid in the trea...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2012.091

    authors: Sipahi OR,Bardak-Ozcem S,Turhan T,Arda B,Ruksen M,Pullukcu H,Aydemir S,Dalbasti T,Yurtseven T,Sipahi H,Zileli M,Ulusoy S

    更新日期:2013-08-01 00:00:00

  • Can Nasal Methicillin-Resistant Staphylococcus aureus Screening Be Used to Avoid Empiric Vancomycin Use in Intra-Abdominal Infection?

    abstract:BACKGROUND:Vancomycin is used widely as empiric therapy for gram-positive organisms in patients with an intra-abdominal infection (IAI), even in those with no history of methicillin-resistant Staphylococcus aureus (MRSA) infection or colonization. Potential adverse effects of vancomycin include nephrotoxicity, increase...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2014.211

    authors: Hennessy SA,Shah PM,Guidry CA,Davies SW,Hranjec T,Sawyer RG

    更新日期:2015-08-01 00:00:00

  • The Bacteremia Caused by Non-Lactose Fermenting Gram-Negative Bacilli in Solid Organ Transplant Recipients.

    abstract:BACKGROUND:Blood stream infections (BSIs) remain as a serious life-threatening condition after solid organ transplant (SOT). In recent years, a progressive growth in the incidence of bacteremia caused by non-lactose fermenting gram-negative bacilli (NLF GNB) has been observed. NLF GNB led to high mortality among SOT re...

    journal_title:Surgical infections

    pub_type: 杂志文章,评审

    doi:10.1089/sur.2015.005

    authors: Wan Q,Ye Q,Huang F

    更新日期:2015-10-01 00:00:00

  • A prospective evaluation of the use of emergency department computed tomography for suspected acute appendicitis.

    abstract:BACKGROUND:Computed tomography (CT) is used increasingly to evaluate suspected cases of acute appendicitis (AA) in the emergency department (ED). This prospective study was performed to test the hypothesis that the evaluation of AA by CT in the ED remains suboptimal and that erroneous interpretation diminishes its util...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/109629601317202687

    authors: Maluccio MA,Covey AM,Weyant MJ,Eachempati SR,Hydo LJ,Barie PS

    更新日期:2001-10-01 00:00:00

  • Influence of bronchoscopy on the diagnosis of and outcomes from ventilator-associated pneumonia.

    abstract:BACKGROUND:Ventilator-associated pneumonia (VAP) is a common healthcare-associated infection affecting as many as 27% of mechanically ventilated patients. Ventilator-associated pneumonia is an important source of morbidity and mortality in the surgical intensive care unit (SICU). The optimal diagnostic method for VAP h...

    journal_title:Surgical infections

    pub_type: 杂志文章

    doi:10.1089/sur.2013.142

    authors: Guidry CA,Mallicote MU,Petroze RT,Hranjec T,Rosenberger LH,Davies SW,Sawyer RG

    更新日期:2014-10-01 00:00:00